Hepatobiliary Research
The Division of Hepatobiliary Surgery at UC Davis Health is deeply committed to improving patient care through pioneering surgical research and innovation. Our faculty are involved in various research activities, including cancer research studies and clinical trials through the UC Davis Comprehensive Cancer Center.
Dr. Alexopolous’s prolific research is dedicated to enhancing liver preservation methods and transplant patient outcomes in addition to advancing techniques in complex liver surgeries. Dr. Gaskill’s research focuses on improving outcomes of patients with hepatobiliary cancers as well as addressing the surgical burden of cancer in resource-limited settings. Dr. Matsuoka has an interest and extensive research in liver transplant outcomes and disparities in liver transplants.
Kim BJ, Arvide EM, Gaskill C, Martin AN, Kawaguchi Y, Chiang YJ, Dewhurst WL, Phan TL, Tran Cao HS, Chun YS, Katz MHG, Vauthey JN, Tzeng CD, Newhook TE. "Risk-stratified posthepatectomy pathways based upon the Kawaguchi-Gayet complexity classification and impact on length of stay." Surg Open Sci. 2022 May 8;9:109-116. doi: 10.1016/j.sopen.2022.04.006. PMID: 35747509; PMCID:PMC9209704.
COVIDSurg Collaborative; GlobalSurg Collaborative. "SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study." Anaesthesia. 2022 Jan;77(1):28-39. doi: 10.1111/anae.15563. Epub 2021 Aug 24. PMID: 34428858; PMCID: PMC8652887.
COVIDSurg Collaborative; GlobalSurg Collaborative. "Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study." Anaesthesia. 2021 Nov;76(11):1454-1464. doi: 10.1111/anae.15560. Epub 2021 Aug 9. PMID: 34371522.
Gaskill CE, Gyedu A, Stewart B, Quansah R, Donkor P, Mock C. "Improving Global Surgical Oncology Benchmarks: Defining the Unmet Need for Cancer Surgery in Ghana." World J Surg. 2021 Sep;45(9):2661-2669. doi: 10.1007/s00268-021-06197-y. Epub 2021 Jun 21. PMID: 34152449.
Gaskill CE, Maxwell J, Ikoma N, Kim MP, Tzeng CW, Lee JE, Katz MHG. "History of preoperative therapy for pancreatic cancer and the MD Anderson experience." J Surg Oncol. 2021 May;123(6):1414-1422. doi: 10.1002/jso.26394. PMID: 33831256.
COVIDSurg Collaborative, GlobalSurg Collaborative. "SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study." Br J Surg. 2021 Sep 27;108(9):1056-1063. doi: 10.1093/bjs/znab101. PMID: 33761533; PMCID: PMC7995808.
COVIDSurg Collaborative; GlobalSurg Collaborative. "Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study." Anaesthesia. 2021 Jun;76(6):748-758. doi: 10.1111/anae.15458. Epub 2021 Mar 9. PMID: 33690889; PMCID: PMC8206995.
Gyedu A, Stewart B, Gaskill C, Salia E, Wadie R, Abantanga F, Donkor P, Mock C. "A Nationwide Enumeration of Operations Performed for Pediatric Patients in Ghana." Eur J Pediatr Surg. 2021 Apr;31(2):199-205. doi: 10.1055/s-0040-1705130. Epub 2020 Apr 2. PMID: 32242327.
Gyedu A, Stewart B, Gaskill C, Donkor P, Quansah R, Mock C. "Benchmarking Global Trauma Care: Defining the Unmet Need for Trauma Surgery in Ghana." J Surg Res. 2020 Mar;247:280-286. doi: 10.1016/j.jss.2019.10.013. Epub 2019 Nov 2. PMID: 31690530; PMCID: PMC7028509.
Gyedu A, Stewart B, Gaskill C, Salia EL, Wadie R, Donkor P, Mock C. "Enumeration of Operations Performed for Elderly Patients in Ghana: An Opportunity to Improve Global Surgery Benchmarking." World J Surg. 2019 Jul;43(7):1644-1652. doi: 10.1007/s00268-019-04963-7. PMID: 30824962; PMCID: PMC6548639.
Click HERE for a complete list of Dr. Gaskill's publications.
Wu WK, Alexopoulos SP, Bacchetta M. "Reply: Xenogeneic cross-circulation of ex vivo human livers or liver xenotransplantation?" Hepatology. 2023 May 22. doi: 10.1097/HEP.0000000000000472. Epub ahead of print. PMID: 37204403.
Ukita R, Wu WK, Liang J, Talackine JR, Patel YJ, Francois SA, Cardwell NL, Flynn CR, Shingina A, Washington MK, Trinh VQ, Bacchetta M, Alexopoulos SP. "Pulmonary artery banding in sheep: a novel large animal model for congestive hepatopathy." J Appl Physiol (1985). 2023 Apr 1;134(4):840-845. doi: 10.1152/japplphysiol.00473.2022. Epub 2023 Feb 9. PMID: 36759164; PMCID: PMC10042593.
Riffert DA, Matsuoka L, Brown DB, Alexopoulos SP. "Recurrent Portal Vein Thrombosis In Liver Transplantation With Renoportal Anastomosis Caused by Spontaneous Reno-Caval Shunts: A Case Report." Transplant Proc. 2023 Apr;55(3):680-683. doi: 10.1016/j.transproceed.2023.02.025. Epub 2023 Mar 23. PMID: 36966084.
Tracy KM, Matsuoka LK, Alexopoulos SP. "Update on combined heart and liver transplantation: evolving patient selection, improving outcomes, and outstanding questions." Curr Opin Organ Transplant. 2023 Apr 1;28(2):104-109. doi: 10.1097/MOT.0000000000001041. Epub 2022 Dec 1. PMID: 36454232; PMCID: PMC9994850
Wu WK, Stier MT, Stokes JW, Ukita R, Patel YJ, Cortelli M, Landstreet SR, Talackine JR, Cardwell NL, Simonds EM, Mentz M, Lowe C, Benson C, Demarest CT, Alexopoulos SP, Shaver CM, Bacchetta M. "Immune characterization of a xenogeneic human lung cross-circulation support system." Sci Adv. 2023 Mar 31;9(13):eade7647. doi: 10.1126/sciadv.ade7647. Epub 2023 Mar 31. PMID: 37000867; PMCID: PMC10065447.
Wu WK, Ukita R, Patel YJ, Cortelli M, Trinh VQ, Ziogas IA, Francois SA, Mentz M, Cardwell NL, Talackine JR, Grogan WM, Stokes JW, Lee YA, Kim J, Alexopoulos SP, Bacchetta M. "Xenogeneic cross-circulation for physiologic support and recovery of ex vivo human livers." Hepatology. 2023 Mar 30. doi: 10.1097/HEP.0000000000000357. Epub ahead of print. PMID: 36988383.
Ziogas IA, Kakos CD, Moris DP, Kaltenmeier C, Tsoulfas G, Montenovo MI, Alexopoulos SP, Geller DA, Pomfret EA. "Systematic review and meta-analysis of open versus laparoscopy-assisted versus pure laparoscopic versus robotic living donor hepatectomy." Liver Transpl. 2023 Mar 6. doi: 10.1097/LVT.0000000000000115. Epub ahead of print. PMID: 36866856.
Ziogas IA, Rodriguez Franco S, Schmoke N, Meguid C, Murphy C, Al-Musawi M, Alexopoulos SP, Schulick RD, Del Chiaro M. "Comparison of Invasive Pancreatic Ductal Adenocarcinoma versus Intraductal Papillary Mucinous Neoplasm: A National Cancer Database Analysis." Cancers (Basel). 2023 Feb 13;15(4):1185. doi: 10.3390/cancers15041185. PMID: 36831527; PMCID: PMC9953895.
Black K, Ziogas IA, Thurm C, Hall M, Hafberg E, Alexopoulos SP, Godown J, Gillis LA. "Pediatric Liver Transplant Survival in Alagille Syndrome Is Comparable to Biliary Atresia-A Linked Database Analysis." J Pediatr Gastroenterol Nutr. 2022 Sep 1;75(3):257-263. doi: 10.1097/MPG.0000000000003522. Epub 2022 Aug 9. PMID: 35696710.
Lebeck Lee CM, Ziogas IA, Agarwal R, Alexopoulos SP, Ciombor KK, Matsuoka LK, Brown DB, Eng C. "A contemporary systematic review on liver transplantation for unresectable liver metastases of colorectal cancer." Cancer. 2022 Jun 15;128(12):2243-2257. doi: 10.1002/cncr.34170. Epub 2022 Mar 14. PMID: 35285949; PMCID: PMC9311758.
Click HERE for a complete list of Dr. Alexopoulos's publications.
Adeniran OR, Nguyen CN, Perez TH, Frantz SK, Matsuoka L, Du L, Gandhi RT, Collins ZS, Matrana MR, Petroziello M, Brower JS, Sze DY, Kennedy AS, Golzarian J, Wang EA, Brown DB. "Overall survival and toxicity of hepatocellular carcinoma Barcelona Clinic Liver Cancer B patients receiving Y90 radioembolization: analysis of the radiation-emitting SIR-spheres in non-resectable liver tumor (RESiN) registry." J Gastrointest Oncol. 2023 Apr 29;14(2):874-885. doi: 10.21037/jgo-22-972. Epub 2023 Mar 6.PMID: 37201079
Riffert DA, Matsuoka L, Brown DB, Alexopoulos SP. "Recurrent Portal Vein Thrombosis In Liver Transplantation With Renoportal Anastomosis Caused by Spontaneous Reno-Caval Shunts: A Case Report." Transplant Proc. 2023 Apr;55(3):680-683. doi: 10.1016/j.transproceed.2023.02.025. Epub 2023 Mar 23.PMID: 36966084
Robinson TJ, Du L, Matsuoka L, Sze DY, Kennedy AS, Gandhi RT, Kouri BE, Collins ZS, Kokabi N, Grilli CJ, Wang EA, Lee JS, Brown DB. "Survival and Toxicities after Yttrium-90 Transarterial Radioembolization of Cholangiocarcinoma in the RESiN Registry." J Vasc Interv Radiol. 2023 Apr;34(4):694-701.e3. doi: 10.1016/j.jvir.2022.10.042. Epub 2022 Dec 9. PMID: 36509236
Hund HC, Frantz SK, Wu H, Adeniran OR, Wong TY, Borgmann AJ, Matsuoka L, Geevarghese S, Alexopoulos S, Shingina A, Meranze SG, Baker JC, Garbett S, Brown DB. "Six-Year Evaluation of Same-Day Discharge following Conventional Transarterial Chemoembolization of Hepatocellular Carcinoma." J Vasc Interv Radiol. 2023 Mar;34(3):378-385. doi: 10.1016/j.jvir.2022.11.029. Epub 2022 Dec 5.PMID: 36481322
Tracy KM, Matsuoka LK, Alexopoulos SP. "Update on combined heart and liver transplantation: evolving patient selection, improving outcomes, and outstanding questions." Curr Opin Organ Transplant. 2023 Apr 1;28(2):104-109. doi: 10.1097/MOT.0000000000001041. Epub 2022 Dec 1.PMID: 36454232 Free PMC article. Review.
Goswami P, Adeniran OR, K Frantz S, Matsuoka L, Du L, Gandhi RT, Collins ZS, Matrana MR, Petroziello M, Brower JS, Sze DY, Kennedy AS, Golzarian J, Wang EA, Brown DB. "Overall survival and toxicity of Y90 radioembolization for hepatocellular carcinoma patients in Barcelona Clinic Liver Cancer stage C (BCLC-C)." BMC Gastroenterol. 2022 Nov 17;22(1):467. doi: 10.1186/s12876-022-02528-y.PMID: 36396989 Free PMC article.
Cui J, Spann A, Shingina A, Schaefer H, Slaughter JC, Matsuoka L, Alexopoulos S, Izzy M. "Predictors of renal recovery in recipients of liver transplant alone who met 2017 simultaneous liver-kidney transplant criteria." Clin Transplant. 2022 Dec;36(12):e14812. doi: 10.1111/ctr.14812. Epub 2022 Oct 5.PMID: 36065935
Riaz A, Trivedi P, Aadam AA, Katariya N, Matsuoka L, Malik A, Gunn AJ, Vezeridis A, Sarwar A, Schlachter T, Harmath C, Srinivasa R, Abi-Jaoudeh N, Singh H. "Research Priorities in Percutaneous Image- and Endoscopy-Guided Interventions for Biliary and Gallbladder Diseases: Proceedings from the Society of Interventional Radiology Foundation Multidisciplinary Research Consensus Panel." J Vasc Interv Radiol. 2022 Oct;33(10):1247-1257. doi: 10.1016/j.jvir.2022.06.025. Epub 2022 Jul 7. PMID: 35809805
Emmons EC, Bishay S, Du L, Krebs H, Gandhi RT, Collins ZS, O'Hara R, Akhter NM, Wang EA, Grilli C, Brower JS, Peck SR, Petroziello M, Abdel Aal AK, Golzarian J, Kennedy AS, Matsuoka L, Sze DY, Brown DB. "Survival and Toxicities after 90Y Transarterial Radioembolization of Metastatic Colorectal Cancer in the RESIN Registry." Radiology. 2022 Oct;305(1):228-236. doi: 10.1148/radiol.220387. Epub 2022 Jun 28. PMID: 35762890
Sealock JM, Ziogas IA, Zhao Z, Ye F, Alexopoulos SP, Matsuoka L, Chen G, Davis LK. "Proposing a Sex-Adjusted Sodium-Adjusted MELD Score for Liver Transplant Allocation." JAMA Surg. 2022 Jul 1;157(7):618-626. doi: 10.1001/jamasurg.2022.1548.PMID: 35583884 Free PMC article.
Click HERE for a complete list of Dr. Matsuoka's publications.