Pharmacology Training Program: From Bench to Bedside
The primary goals of this Pharmacology Training Program are to provide advanced training in basic and translational pharmacological sciences and to broaden the research perspectives and skills of trainees interested in pharmacology research by leveraging the highly collaborative multidisciplinary biomedical science environment at UC Davis to provide trainees with an “inside look” at and understanding of the drug development process from target identification into the clinic. A secondary goal is to foster interactions among faculty, researchers, post- and pre-doctoral fellows from different departments and Graduate Groups that share an interest in pharmacological sciences. Our vision is that these goals will translate into increased understanding of and interest in the concepts, challenges and opportunities in pharmacology research and therapeutics, as well as increased collaborations between established research scientists in pharmacology and their future colleagues in basic and clinical research across academic, government and private sectors.
Students eligible to apply to the Pharmacology Training Program should be in their first, second, or third year of a graduate program listed below and should be working on a thesis project related to pharmacology. Other graduate groups can be considered on a case by case basis. The student must also be a U.S. citizen or permanent resident, and be in good academic standing. The Pharmacology pre-doctoral graduate student training program is supported due to NIH T32 GM099608 grant funding.
|Pharmacology and Toxicology|
|Molecular, Cellular and Integrative Physiology|
Donald M. Bers
|Becket, Laurel A.||Pub Hlth|
|Berglund, Lars||Intern Med|
|Berman, Robert F.||Neurosurg|
|*Bers, Donald M.||Pharmacol|
|Chiamvimonvat, Nipavan||Intern Med|
|Clancy, Colleen E.||Pharmacol|
|DeGregorio, Michael||Intern Med|
|Deng, Wenbin||Cell Biol Anat|
|Ghosh, Paramita M.||Biochem, Molec Med|
|*Gorin, Fredric||Neurol (also SOVM)|
|Hagerman, Paul J.||Biochem, Molec Med|
|*Hell, Johannes W.||Pharmacol|
|Hertz-Picciotto, Irva||Pub Hlth|
|Kenyon, Nicholas J||Intern Med|
|Knowlton, Anne A .||Intern Med|
|Kung, Hsing-Jien||Biochem, Molec Med|
|*Lam, Kit||Biochem, Molec Med|
|Pinkerton, Kent E.||Pediatrics|
|Ripplinger, Crystal M||Pharmacol|
|Rocke, David M.||Pub Hlth|
|Segal, David J.||Biochem, Molec Med|
|Trainor, Brian C.||Psychol|
|Barthold, Stephen W.||Path/Micro/Immu|
|Buckpitt, Alan R||Molec Biosci|
|Havel, Peter J.||Molec Biosci|
|Kynch, Heather||Molec Biosci|
|*Lein, Pamela J.||Molec Biosci|
|*Pessah, Isaac N.||Molec Biosci|
|Van Winkle, Laura||Anat-Physiol|
|Athanasiou, Kyriacos A.||BME|
|Fyhrie, David P.||BME|
|Franz, Annaliese K.||Chem|
|Lebrilla, Carlito B.||Chem|
Shaw, Jared T.
|Rice, Robert H.||Envir Tox|
|Bodine, Sue C.||Neur/Physiol|
|Goldman, Mark S.||Neur/Physiol|
|Privalsky, Martin L.||Microbiol|
*Executive Committee Member
|Bers, Donald M.||Pharmacol|
|Gorin, Fredric||Neurol (also SOVM)|
|Hell, Johannes W.||Pharmacol|
|Lam, Kit||Biochem, Molec Med|
|Lein, Pamela J.||Molec Biosci|
|Pessah, Isaac N.||Molec Biosci|
Nicole De Jesus
PhD, Biomedical Engineering, Projected 2014
Research Project Title: “The Role of Inflammation in Electrophysiological Remodeling and Arrhythmogenesis Following Myocardial Infarction”
Trainer: Crystal Ripplinger
PhD, Pharmacology and Toxicology, Projected 2016
Research Project Title: “How the Tyrosine Kinases Pyk2 and Src are Involved in the Regulation of Cav1.2 Activity by PKC”
Trainer: Johannes Hell
PhD, Physiology, Projected 2014
Research Project Title: “CaMKII Based Regulation of the Cardiac Voltage Gated Na+ Channel”
Trainer: Donald Bers
PhD, Pharmacology and Toxicology, Projected 2014
Research Project Title: “Discovery and characterization of compounds that rescue Friedreich’s Ataxia biochemical defects in vitro and in vivo”
Trainer: Gino Cortopassi
PhD, Pharmacology and Toxicology, Projected 2016
Research Project Title: “Investigation of Potential Therapeutic Strategies to Mitigate Toxicity Induced by the Convulsant Poison Tetramethylenedisulfotetramine”
Trainer: Bruce Hammock
Chalk Talks are First Tuesdays of the Month as Scheduled by Trainees
Retreat – TBD
The trainee requirements for this position include:
- Enrollment in the graduate-level course Drug Discovery and Development (PHA 207, 3 credits), unless trainee can show evidence of completion of an analogous course. Students that have not taken PTX 201 or an equivalent course covering pharmacokinetics/dynamics will be offered a supplementary 8 hour module on this topic.
- Participation in an interactive course Problem Solving in Drug Development (each quarter);
- Participation in a once-a-month seminar that includes seminar attendance and active involvement in organizing the seminar series, including inviting and hosting speakers;
- Participation in a monthly chalk talk during which trainees discuss their research advances and challenges;
- Participation in an annual retreat.
- Students and their faculty trainers need to commit to participate in this program for 3 years (i.e., participation in Problem Solving in Drug Development, the once-a-month seminar, monthly chalk talks, and the yearly retreats).
To assure full consideration, complete applications should be submitted by May 27. To apply (predoctoral students) or to upload letters of recommendation (Trainers), login to the Pharmacology training grant application system: http://pharmt32.ucdavis.edu/ (Accessible with Kerberos User Name and Password).
A complete application should consist of the following:
- The applicant’s biographical sketch or CV.
- A concise Research Project plan describing the proposed doctoral dissertation research, its relevance to pharmacology and the applicant’s career goals.
- Applicant’s graduate and undergraduate academic records.
- A signed statement indicating that both the trainee and the training faculty mentor agree to comply with the requirements of the pharmacology training program including regular participation in the seminars, Chalk Talks and Retreat not only during but also after the period of active funding support while the trainee is matriculated as full-time graduate students at UC Davis.
- Three letters of recommendation, one of which must be from a training faculty who has agreed to mentor the applicant’s thesis research.
Please have the following information on hand when completing the online application, since our system will not allow you to save information and go back to it.
Kerberos Login ID and Password; Student ID; Department; Lab Phone #; Email address; Major Professor (Trainer); Graduate Group; Year that you entered the UC Davis graduate program; Current GPA; Research Project Title; Research Project; Academic History information such as Degrees, Institutions, GPA, Years Awarded, Discipline; GRE Scores; Subject Test Scores; Demographic Info (this is voluntary); one PDF copy of your Transcripts, PDF copy of your CV, and PDF copy of the signed Commitment Letter (item 4 above).
UC Davis has a strong multidisciplinary and collaborative environment in research and training related to this Pharmacology Training Program (PTP). The 59 Training Faculty are from 22 departments in 6 colleges, where extensive collaborative interaction exist (e.g. many are members of the Pharmacology-Toxicology (PTX) Graduate Group, now in its 37th year). The PTP includes faculty trainers that smoothly span colleges, academic departments and centers.
The PTP objective is to provide predoctoral trainees with the core educational and research training required for translating pre-clinical mechanistic therapeutic discoveries into clinical trials. All of the educational components necessary for this translation PTP are provided by collaborative teaching and training. The training faculty are well-funded with ongoing disease-oriented and therapeutic discovery projects at UC Davis and some have pharmaceutical industry partners. Their foci range from identifying novel therapeutic molecular targets, making or identifying therapeutic molecules, novel developing cell targeting strategies, immune-mediated, and stem cell pre-clinical therapeutics, to clinical trials being conducted at the UC Davis NIH-funded Clinical and Translational Science Center (CTSC), NIH-designated Cancer Center, and within the UCD Health System.
The very rich and collaborative overall science environment at UC Davis, powerful and numerous state-of-the-art core facilities and centers will provide trainees with outstanding research opportunities (e.g. spanning from Chemistry’s emphasis on pharmaceutical chemistry, imaging molecules (from single molecule to in vivo), genomics, molecular/system modeling, stem cell center, unique animal models (nationally recognized mouse center, Veterinary School and Primate Center) and CTSC.
The disease targets of the training faculty cover a broad spectrum, but include strength in cardiovascular, neurosciences, cancer, and inflammatory diseases. All PTP trainees will develop a solid foundation in both modern physiology and pharmacology, including pharmacokinetics, pharmacodynamics, pharmacotoxicology, drug metabolism, drug discovery and translation, biostatistics and responsible conduct of research. The PTP also provides training in skills that promote professional development. Previous trainees of the training faculty have had highly successful careers in both academia and industry. This PTP will provide an exciting training opportunity for motivated students and fellows in translational pre-clinical therapeutics.