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Department of Physiology and Membrane Biology

Department of Physiology and Membrane Biology

Aldrin Gomes, Ph.D.

Aldrin Gomes, Ph.D.

Associate Professor
191 Briggs Hall
Davis Campus
(530) 752-3207
e-mail

Recent/Current Research Funding

National Institute of Health

American Heart Association

Graduate Group Affiliations

Molecular, Cellular and Integrative Physiology

Biochemistry, Molecular, Cellular and Developmental Biology

Research Interests

We are interested in the molecular mechanisms of signal transduction, particularly in muscle contraction and cardiovascular disease. The two main research areas in my laboratory are: the role of the proteasome in normal, protected and diseased cardiac and skeletal muscle and the role of troponin in calcium regulation of muscle contraction in hypertrophic, dilated and restrictive cardiomyopathies. For details about my research go to:  http://www.npb.ucdavis.edu/labs/gomes/gomeslab2009.htm

 

Representative Publications

2014  Cui, Z., Scruggs, S.B., Gilda, J.E., Ping, P., Gomes, A.V. Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. in press.

2014  Cui, Z., Hwang, S.M., and Gomes A.V. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 34(1):96-109.

2014  Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Human Molecular Genetics. 23(1):209-225 (cover picture article).

2014  Cui Z, Gilda JE, Gomes AV. Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 446: 44–52 (cover picture article).

2013  Dewey, S., Lai, X., Witzmann,F., Sohal, M., Gomes, A.V. Proteomic Analysis of Hearts from Akita Mice Suggests Increases in Soluble Epoxide Hydrolase and Antioxidative Programming are Key Changes in Early Stages of Diabetic Cardiomyopathy. Journal of Proteome Research, 12(9): 3920–3933.

2013  Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research, 100(1):63-73

2013  Gilda, J.E., Gomes, A.V. How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. Journal of Molecular Cellular Cardiology, 62(108): 108-110.

2013  Gilda, J.E., Gomes, A.V. Stain free total protein staining is a superior loading control to β-actin for Western blots. Analytical Biochemistry, 440(2): 186-188.

2013  Rajagopalan, V.,Zhao, M.,Reddy, S., Fajardo, G.,Wang, X., Dewey, S., Gomes, A,V., Bernstein, D. Altered Ubiquitin-Proteasome Signaling in Right Ventricular Hypertrophy and Failure. American Journal of Physiology, 305(4): H551-62.

2012  Iorga, A., Dewey, S., Partow-Navid1, R., Gomes AV, Mansoureh, E. Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice. PLOS One. 7(11): e48601.

2012  Xu, Q., Cui, Z., Venkatraman, G., Gomes, A.V. The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophysical Reviews 4, 125-135.

2012  Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen ,S., Miller, T., Parvatiyar, M.S,. Potter J.D. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 287:37362-70.

2012  Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 26:2986-99.

2011  Cui, Z., Dewey, S., Gomes, A.V. Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am. J. Cardiovasc. Dis. 1: 274-292.

2011  Hwee, D.T., Gomes, A.V., Bodine, S.C. Cardiac Proteasome Activity in Muscle Ring Finger-1 Null Mice at Rest and Following Synthetic Glucocorticoid Treatment. Am. J. Physiol. Endocrinol. Metab. 301:E967-77.

2010  Xu, Q., Dewey, S., Nguyen, S., Gomes, A.V. Malignant and benign mutations in familial cardiomyopathies: Insights into mutations linked to complex cardiovascular phenotypes. J. Mol. Cell. Cardiol. 48: 899-909.

2010  Dewey, S., Xu, Q., Gomes, A. Static and dynamic properties of the HCM myocardium. J Mol Cell Cardiol. 49:715-8

2010  Divald, A., Kivity, S., Wang, P., Hochhauser, E., Roberts, B., Teichberg, S., Gomes, A.V., Powell, S.R., Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circulation Research. 106: 1829-38.

2010  Dewey, S., Gomes, A.V. Non-Antigen Processing Diabetic Cardiac Immunoproteasomes. J. Mol. Cell. Cardiol. 49: 1-4.

2010  Tikunova, S.B., Liu, B., Swindle, N., Little, S.C., Gomes, A.V., Swartz, D.R., Davis, J.P. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 49:1975-84.

2009  Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 8,302-15.

2009  Mayr, M., Liem, D., Zhang, J., Li, X., Avliyakulov, N.K., Yang, J.I., Young, G., Vondriska, T.M., Ladroue, C., Madhu, B., Griffiths, J.R., Gomes, A., Xu, Q., Ping, P. Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J. Mol. Cell. Cardiol. 46,268-77.

2009  Mayr M., Grainger, D., Mayr, U., Leroyer, A.S., Leseche, G., Sidibe, A., Herbin, O., Yin, X., Gomes, A.V., Madhu, B., Griffiths, J.R., Xu, Q., Tedgui, A. and Boulanger, C.M. Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ. Cardiovasc. Genet. 2: 379 - 388.

2008  Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. Cardiac troponin T forms a tetramer in vitro. Biochemistry. 47, 1970-6.

2008  Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 283:20484-94.

2007  Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 6:2021-2031.

2006  Gomes, A.V. Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.

2006  Zong, C., Gomes, A.V. Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.

2005  Gomes, A.V., Liang, J., Potter J.D. Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 280, 30909-15.

2005  Gomes, A.V., Harada, K., Potter J.D. A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Calcium-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 39, 754-65.

2005  Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 280, 17584-92.

 

Recent/Current Teaching

EXB110, Exercise Metabolism