Electroneutral Ion Transport: Na/H and K/H Exchange
NHE1 Structure Function Relationships
Hypoxic and Ischemic Cytotoxicity
Cell Volume and pH Regulation
Membranes and Transport
Red blood cells
Tumor Growth and Proliferation

Representative Publications

1977 Cala, Peter M. Volume regulation by flounder red blood cells in anisotonic media. Journal of General Physiology 69:537-552.

1980 Cala, Peter M. Volume regulation by Amphiuma red blood cells: The membrane potential and its implications regarding the nature of the ion flux pathways. Journal of General Physiology 76:683-708.

1983 Cala, Peter M. Volume regulation by red blood cells: Mechanisms of ion transport. Molecular Physiology 4:33-52.

1983 Cala, Peter M. Volume regulation by Amphiuma red blood cells: The role of Ca⁺2 as a modulator of the alkali metal/proton exchanger. Journal of General Physiology 82:761-784.

1990 Anderson, S.E., E. Murphy, C. Steenbergen, R.E. London, and P.M. Cala. Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. American Journal of Physiology 259 (Cell Physiol. 28):C940-C948.

1999 McLean, LA, S. Zia, F. A. Gorin, and P. M. Cala. Cloning and expression of the Na⁺exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. American Journal of Physiology 276 (Cell Physiol. 45): C1025-C1037.

2000 McLean LA, J. Roscoe, N. K. Jorgensen, F. A. Gorin, and P. M. Cala. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. American Journal of Physiology 278: (Cell Physiol. 47) C676-C688.

2003 Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am J Physiol Cell Physiol 284: C1561-C1576.

2005 Anderson, S.E., D. M. Kirkland, A. Beyschau, and P.M. Cala. Acute effects of 17ß-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am J. Physiol: Cell Physiol. 288: C57-C64.

2007 King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 282(27): 19716-27. Epub 2007 May 10.

2008 Ortiz-Acevedo A, Rigor III RR, Maldonado HM, Cala PM. Activation of 2 Na +/H+ and K+/H+ Exchange by Calyculin A in Amphiuma tridactylum Red Blood Cells; implications for the control of volume-induced ion flux activity. Am J Physiol Cell Physiol, 284: C-1123-32.

Recent/Current Teaching

HPH100, Special Study-Physiology
MCP210, Advanced Physiology
HPH400, Human Physiology
SUR493C/HPH493, Care of the Critically Ill Surgical Patient

Honors and Awards

National Institute of Health Merit Award

President, Association of Chairs of Physiology Departments

Past President, Association of Chairs of Physiology Departments