FacultySteve Anderson, Ph.D.
Research Physiologist Graduate Group Affiliations |
Research Interests Fluid and electrolyte transport with special emphasis on Na/H and Na/Ca exchange in the heart and Na/H exchange and Na+K+2Cl cotransport in the Blood Brain Barrier. Current studies are aimed at better understanding the role of Na uptake via these transporters in ischemic brain and myocardium as well under conditions of diabetic ketoacidosis. Ongoing studies use magnetic resonance imaging and spectroscopy to assess changes in brain and myocardial Na, pH, Ca, and high-energy phosphates. Diffusion and perfusion weighted imaging are also used to determine cerebral edema and blood flow. Representative Publications 2005 Anderson, S.E., D. M. Kirkland, A. Beyschau, and P. M. Cala. Acute effects of 17ß-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am. J. Physiol: Cell Physiology 288(1): C57-C64. 2005 Lam, T.I., S.E. Anderson, N. Glaser and M. O’Donnell. Bumetanide reduces cerebral edema formation in rats with diabetic ketoacidosis. Diabetes 54: 510-516. 2006 Anderson, S.E., Liu, H., Beyschau, A., and Cala, P.M. Effects of cold cardioplegia on pH, Na and Ca in newborn rabbit hearts. Am J Physiol Heart Circ Physiol 290(3):H1090-H1097. 2006 O'Donnell, M. E., T. I. Lam, L. Q. Tran, S. Foroutan, and S. E. Anderson. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 26(10):1234-1249. 2006 Pedersen, S. F., M. E. O'Donnell, S. E. Anderson, and P. M. Cala. Physiology and pathophysiology of Na/H+ exchange and Na+/K+/2Cl- cotransport in the heart, brain, and blood. Am J Physiol Regul Integr Comp Physiol 291(1):R1-R25. 2007 Medina, D. C., D. M. Kirkland, M. F. Tavazoie, C. S. Springer Jr., and S. E. Anderson. Na+/Ca2+-exchanger-mediated Mn2+-enhanced 1H2O MRI in hypoxic, perfused rat myocardium. Contrast Media and Molecular Imaging 2(5):248-257. 2008 Yuen, N., S. E. Anderson, N. Glaser, D. J. Tancredi, and M. E. O'Donnell. Cerebral Blood Flow and Cerebral Edema in Rats with Diabetic Ketoacidosis. Diabetes 57(10):2588-2594. Recent/Current Teaching
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