Fluid and electrolyte transport with special emphasis on Na/H and Na/Ca exchange in the heart and Na/H exchange and Na+K+2Cl cotransport in the Blood Brain Barrier. Current studies are aimed at better understanding the role of Na uptake via these transporters in ischemic brain and myocardium as well under conditions of diabetic ketoacidosis. Ongoing studies use magnetic resonance imaging and spectroscopy to assess changes in brain and myocardial Na, pH, Ca, and high-energy phosphates. Diffusion and perfusion weighted imaging are also used to determine cerebral edema and blood flow.
2013 O'Donnell, M. E., Y. J. Chen, T. I. Lam, K. C. Taylor, J. H. Walton, and S. E. Anderson. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab 33(2):225-234. PMCID 3564192
2010 Liu, H., P. M. Cala, and S. E. Anderson. Na/H Exchange Inhibition Protects Newborn Heart from Ischemia/reperfusion Injury by Limiting Na+-dependent Ca2+ Overload. Journal of Cardiovascular Pharmacology, 55(3):227-233.
2008 Yuen, N., S. E. Anderson, N. Glaser, D. J. Tancredi, and M. E. O'Donnell. Cerebral Blood Flow and Cerebral Edema in Rats with Diabetic Ketoacidosis. Diabetes 57(10):2588-2594.
2007 Medina, D. C., D. M. Kirkland, M. F. Tavazoie, C. S. Springer Jr., and S. E. Anderson. Na+/Ca2+-exchanger-mediated Mn2+-enhanced 1H2O MRI in hypoxic, perfused rat myocardium. Contrast Media and Molecular Imaging 2(5):248-257.
2006 Pedersen, S. F., M. E. O'Donnell, S. E. Anderson, and P. M. Cala. Physiology and pathophysiology of Na/H+ exchange and Na+/K+/2Cl- cotransport in the heart, brain, and blood. Am J Physiol Regul Integr Comp Physiol 291(1):R1-R25.
2006 O'Donnell, M. E., T. I. Lam, L. Q. Tran, S. Foroutan, and S. E. Anderson. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 26(10):1234-1249.
2005 Anderson, S.E., D. M. Kirkland, A. Beyschau, and P. M. Cala. Acute effects of 17ß-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am. J. Physiol: Cell Physiology 288(1): C57-C64.