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Department of Radiology

John M. Boone, M.S., Ph.D. View profile as PDF

Clinical Interests

Dr. Boone has studied various aspects of breast imaging, including breast cancer screening, diagnosis and therapy, for nearly two decades. For the past decade, Dr. Boone's laboratory has focused on the assessment of dedicated computed tomography (CT) for breast imaging. Two breast CT scanners have been designed and deployed, with nearly 300 patients imaged in total. Dr. Boone is also interested in whole-body CT imaging, and currently chairs the International Committee on Radiological Units Committee on Computed Tomography.


Vice Chair of Research, Radiology


Cancer, Radiology, Radiology Physics



Radiology Physics

Center/Program Affiliation:


Lawrence J. Ellison Ambulatory Care Center
* Lawrence J. Ellison Ambulatory Care Center
4860 Y St.,, Suite 0100
Sacramento, CA 95817
Driving Directions
Phone: 916-734-0655


M.S., UC Irvine, Irvine, California, 1981
Ph.D., UC Irvine, Irvine, California, 1985
B.A., UC Berkeley, Berkeley, California, 1979


Health Care Affiliates, Inc., Laguna Hills, California, 1983-1985

Board Certifications:

American Board of Radiology, Diagnostic Radiological Physics, 1988

Professional Memberships:

American Association for the Advancement of Science
American Association of Physicists in Medicine (Fellow)
American College of Radiology (Fellow)
Society of Breast Imaging (Fellow)
The International Society for Optical Engineering (SPIE)

Select Recent Publications:

Chamie K, Kurzrock EA, Evans CP, Litwin MS, Koppie TM, Wootton-Gorges SL, Boone JM, Lara PN Jr., Devere White RW. Secondary malignancies among nonseminomatous germ cell tumor cancer survivors. Cancer 2011 Mar 15.

Huang SY, Boone JM, Yang K, Packard NJ, McKenney SE, Prionas ND, Lindfors KK, Yaffee MJ. The characterization of breast anatomical metrics using dedicated breast CT. Med Phys. 2011 Apr;38(4):2180-91.

Kalender WA, Beister M, boone JM, Kolditz D, Vollmar SV, Weigel MC. High-resolution spiral CT of the breast at very low dose: concept and feasibility considerations. Eur Radiol 2011 Jun 9.

Lam D, Wootton-Gorges SL, McGahan JP, Stern R, Boone JM. Abdominal pediatric cancer surveillance using serial computer tomography: evaluation of organ absorbed dose and effective dose. Semin Oncol. 2011 Feb;38(1):128-35.

Prionas ND, Huang Sy, Boone JM. Experimentally determined spectral optimization for dedicated breast computed tomography. Med Phys. 2011 Feb;38(2):646-55.

McCollough CH, Leng S, Yu L, Cody DD, Boone JM, McNitt-Gray MF. CT dose index and patient dose: they are not the same thing. Radiology. 2011 May;259(2):311-6.

McKenney SE, Nosratieh A, Gelskey D, yang K, Huang SY, Chen L, Boone JM. Experimental validation of a method characterizing bow tie filters in CT scanners using a real-time dose probe. Med Phys. 2011 Mar;38(3):1406-15.

Prionas ND, Gillen MA, Boone JM. Longitudinal volume analysis from computed tomography: Reproductibility usiing adrenal glands as surrogate tumors. J Med Phys. 2010 Jul;35(3):174-80.

Prionas ND, Lindfors KK, Ray S, Huang SY, Beckett LA, Monsky Wl, Boone JM. contrast-enhanced dedicatd breast CT: initial clinical experience. Radiology 2010 Sept;256(3):714-23.

Prionas ND, Ray S, Boone JM. Volume assessment accuracy in computed tomography: a phantom study. J Appl Clin Med Phys. 2010 Apr 16;11(2):3037.

Yang K, Huang Sy, Packard NJ, Boone JM. Noise variance analysis using a flat panel x-ray detctor: a method for additive noise assessment with application to breast CT applications. Med Phys. 2010 Jul;37(7):3527-37.

Boone JM. Method for evaluating bow tie filter angle-dependent attenuation in CT: theory and simulation results. Med Phys 2010 jan;37(1):40-8.

Lindfors KK, Boone JM, Newell MS, D'Orsi CJ. Dedicated breast computed tomography: the optimal cross-sectional imaging solution? Radiol Clin North Am. 2010 Sep;48(5):1043-54.

Dixon RL, Boone JM. cone Beam CT dosimetry: a unified and self-consistent approach including all scan modalities--with or without phantom motion. Med Phys. 2010 Jun;37(6):2703-18.

Bowen S, Wu Y, Chaudhari A, Packard NJ, Burkett GW, Yang K, Lindfors KK, Shelton OK, Hagge R, Borowsky AD, Martinez SR, Oi J, Boone JM. Initial characterization of a dedicated breast PET/CT scanner during human imaging. Journal?? 50(9):1401-1408, 2009

Li CM, Segars WP, Tourassi GO, Boone JM, Dobbins III JT. Methodology for generating a 3D computerized breast phantom from empirical data. Med Phys, 36(7):3122, 2009

Yang K, Kwan AL, Huang SY, Packard NJ, Boone JM. Noise power properties of a cone-beam CT system for breast cancer detection. Med Phys, 35(12):5317-27, 2009

Wu Y, Bowen SL, Yang K, Packard N, Fu L, Burkett G, Oi J, Boone JM, Cherry SR, Badawi RD. PET characteristics of a dedicated breast PET/CT scanner prototype. Phys Med Biol, 54(13):4273-87, 2009

Boone JM, Brunberg JA. Computed tomography use in a tertiary care university hospital. J Am Coli Radiol, 5(2):132-8, 2008

Giger ML, Chan H-P, Boone J. Anniversary Paper: History and status of CAD and quantitative imaging analysis: The role of Medical Physics and AAPM. Med Phys, 35:5799-5820, 2008

Huang SY, Boone JM, Yang K, Kwan AL, Packard NJ. The effect of skin thickness determined using breast CT on mammographic dosimetry. Med Phys, 35(4):1199-206, 2008