Alice F. Tarantal, Ph.D.

Professor
Primate Center Lab, Davis Campus
(530) 752-6680
e-mail

Recent/Current
Research Funding

National Institutes of Health

California Institute for Regenerative Medicine

Graduate Group Affiliations

Biomedical Engineering

Biochemistry, Molecular,
Cellular and
Developmental Biology

Comparative Pathology

Clinical Research

Research Interests

Dr. Tarantal’s research program includes the following areas of translational research:

• Gene therapy
• Stem and progenitor cell therapies
• Pediatric models of human disease
• Fetal:maternal microchimerism
• In vivo imaging applications

Projects focus on hematopoietic, mesenchymal, endothelial, and embryonic stem cells for tissue regeneration and repair and transplantation.

The Center for Fetal Gene Transfer for Heart, Lung, and Blood Diseases conducts research on crucial questions in gene therapy for the fetus and infant. 

The Center of Excellence in Translational Human Stem Cell Research consists of projects that encompass central themes of cell expansion and reconstitution, transplantation and cell fate, pediatric nonhuman primate models, and in vivo imaging.

 

Representative Publications

2007  Butt MJ, Tarantal AF, Jimenez DF, and Matsell DG. Collecting duct epithelial-mesenchymal transition in fetal urinary tract obstruction. Kidney International 72:936-944. (Cover)

2008  Hacia JG, Lee CC, Jimenez DF, Karaman MW, Ho VV, Siegmund KD, and Tarantal AF. Age-related gene expression profiles of rhesus monkey bone-marrow derived mesenchymal stem cells. Journal of Cellular Biochemistry 103:1198-1210.

2008  Huang J, Lee CCI, Sutcliffe JL, Cherry SR, and Tarantal AF. Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-PTSM for microPET. Molecular Imaging 7:1-11.

2009  Tarantal AF, Lee CCI, and Itkin-Ansari P. Real-time bioluminescence imaging of macroencapsulated fibroblasts reveal allograft protection in rhesus monkeys (Macaca mulatta). Transplantation 88:38-41.

2009  Batchelder CA, Lee CCI, Matsell DG, Yoder MC, and Tarantal AF. Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors. Differentiation 78:45-56. (Cover)

2010  Tarantal AF and Lee CCI. Long-term luciferase expression monitored by bioluminescence imaging after AAV-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta). Human Gene Therapy 21:143-148. (Cover and Commentary)

2010  Lee CCI, Christensen J, Yoder MC, and Tarantal AF. Clonal analysis and hierarchy of human bone marrow mesenchymal stem and progenitor cells. Experimental Hematology 38:46-54.

2010  Nakayama KH, Batchelder CA, Lee CCI, and Tarantal AF. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Engineering 16:2207-2216.

2010  Batchelder CA, Lee CCI, Martinez ML, and Tarantal AF.   Ontogeny of the kidney and renal development in the rhesus monkey (Macaca mulatta).  Anatomical Record 293:1971-1983.

2010  Ivanova L, Hiatt MJ, Yoder MC, Tarantal AF, and Matsell DG.  Ontogeny of CD24 in the human kidney. Kidney International 77:1123-1131.

2010  Nakayama KH, Batchelder CA, Lee CCI, and Tarantal AF.  Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering.  Tissue Engineering Part A 16:2207-2216.

2011  Nakayama KH, Batchelder CA, Lee CCI, and Tarantal AF.  Renal tissue engineering with decellularized rhesus monkey kidneys: Age-related differences. Tissue Engineering Part A 17:2891-2901.

2011  Wang L, Bell P, Lin J, Calcedo R, Tarantal AF, and Wilson JM. AAV8-mediated hepatic gene transfer in infant rhesus monkeys (Macaca mulatta). Molecular Therapy 19:2012-2020.

2012  Tarantal AF, Lee CCI, Batchelder CA, Christensen JE, Martinez ML, Prater D, and Cherry SR. Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal monkeys.  Molecular Imaging and Biology 14:197-204.

2012  Shelley WC, Huang L, Critser PJ, Leapley AC, Mead LE, Zeng P, Prater D, Ingram DA, Tarantal AF, and Yoder MC. Changes in the frequency and in vivo vessel-forming ability of rhesus monkey circulating endothelial colony-forming cells across the lifespan (birth to aged). Pediatric Research 71:156-161.

2012  Tarantal AF, Giannoni F, Lee CCI, Wherley J, Sumiyoshi T, Hollis R, Martinez M, Leapley A, Kahl C, Louie SG, and Kohn DB.  Non-myeloablative conditioning regimen to increase engraftment of gene-modified hematopoietic stem cells in young rhesus monkeys. Molecular Therapy 20:1033-1045.

2012  Trnka P, Hiatt MJ, Tarantal AF, and Matsell DG. Congenital urinary tract obstruction: defining markers of developmental kidney injury.  Pediatric Research 72:446-454.

2012  Tarantal AF and Skarlatos SI.  Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases: An NHLBI resource for the gene therapy community. Human Gene Therapy 23:1130-1135.

 

Recent/Current Teaching

CHA400, Development, Gross and Radiographic Anatomy

CLH220, Basics of Stem and Progenitor Cells

CLH221, Literature in Stem Cell Biology

Mentored Clinical Research Training Program - Pre-Clinical Models Curriculum

Scientific Director, UC Davis CIRM Stem Cell Training Program

Chair, Designated Emphasis in Stem and Progenitor Cells

 

Teaching and Research Awards

• 2004/05 School of Medicine Faculty Award