Department of Cell Biology and Human Anatomy

Department of Cell Biology and Human Anatomy

Paul Knoepfler, Ph.D.

Paul Knoepfler

Associate Professor
633A Shriners Hospital, Sacramento Campus
(916) 453-2289
e-mail


Recent/Current
Research Funding

National Institute of Health

CA Institute for Regenerative
Medicine

National Cancer Institute Howard Temin Award Grant

St. Baldrick's Foundation

Graduate Group Affiliations

Genetics

Biochemistry, Molecular, Cellular and Developmental Biology

Neuroscience

Research Interests

WHAT CONTROLS STEM AND CANCER CELL BIOLOGICAL BEHAVIOR? We are analyzing how the pluripotency control machinery goes awry during cancer. Our lab studies the molecular programming of embryonic and neural stem cells as well as cancer stem cells. We are studying the genomic and epigenomic events that inflence pluripotency and tumorigenicity. We are particularly interested in pediatric nervous system tumors, but also glioblastoma.

For more information please visit the Knoepfler lab homepage at: http://www.chromatin.com/

 

Representative Publications

2013

Riggs JW,
Barrilleaux B,
Varlakhanova N,
Bush K,
Chan V,
and Knoepfler PS. Induced pluripotency and oncogenic transformation are related processes. Stem Cells & Dev. 2013 Jan 1;22(1):37-50.

Knoepfler PS. Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians. Regen Med. 2013 Mar;8(2):223-5.

2012

Meissen JK , Yuen BTK, Kind T, Riggs JW, Barupala DK, Knoepfler PK*, and Fiehn O*. Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PLoS One 2012;7(10):e46770.  *co-corresponding authors.

Laskowski AI and Knoepfler PS. Utf1: Goldilocks for ESC bivalency. Cell Stem Cell 2012; Dec 7;11(6):732-4.

Pshenichnaya I, Schouwey K, Armaro M, Larue L, Knoepfler PS, Eisenman RN, Trumpp A, Delmas V, and Beermann F. Constitutive gray hair in Mice induced by Melanocyte-specific deletion of c-Myc. 2012 Pigment Cell Melanoma Res. 2012 Mar 15.

Martínez-Cerdeño V, Lemen JM, Chan V, Wey A, Lin W, Dent SR, and Knoepfler PS. N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS One. 2012;7(6):e39456.

Knoepfler PS. Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells. Regenerative Medicine. 2012. 2012; Sep;7(5):713-20.

2011

Dominguez-Frutos E.,  Lopez Hernandez I., Vendrell V., Gallozzi M., Gutsche K., Sharpe J., Knoepfler PS, Eisenman RN, Trumpp A., and Schimmang T. N-myc controls proliferation, morphogenesis and patterning of the inner ear.  J. NeuroSci. 2011 31(19):7178-89.

Barrilleaux B. and Knoepfler PS. Overexpression of oncogenes in human cells using ecotropic lentivirus for enhanced biosafety. J Vis Exp. 2011 Jul 24;(53). 

Barrilleaux B. and Knoepfler PS. Inducing iPS cells to escape the dish. Cell Stem Cell.2011 Aug 5;9(2):103-11.

Varlakhanova NV, Cotterman RF, Bradnam K, Korf I, and Knoepfler PS. Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics & Chromatin. 2011 Nov 4;4(1):20.

Knoepfler PS. My Year As A Stem Cell Blogger. Nature. 475(7357):425.

Barrilleaux B. and Knoepfler PS. Overexpression of oncogenes in human cells using ecotropic lentivirus for enhanced biosafety. J Vis Exp. 2011 Jul 24;(53). pii: 2822

Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler PS, Eisenman RN, Trumpp A, Giráldez F, Schimmang T. N-myc Controls Proliferation, Morphogenesis, and Patterning of the Inner Ear. J. Neurosci 2011 31(19): 7178-7189.

 

Recent/Current Teaching

MCB 213, Developmental Biology

CHA 402, Cell and Tissue Biology

CHA 199, Undergraduate Research

NSC 290C, Research Conference in Neuroscience

NSC 299, Graduate Research

 

Teaching and Research Awards

  • Leukemia & Lymphoma Society Special Fellowship, 2002-2005
  • Howard Temin Award, NCI, 2005-2010
  • Brain Tumor Society Award: 2007-8 Steven C. Higgins Leadership Chair of Research
  • March of Dimes Basil O'Conner Starter Scholar Award, 2008-9.
  • CIRM New Faculty Award: 2009-2014