Dr. Yu’s research interests include noncoding RNA pharmacoepigenetics and cancer therapy. The ultimate goal of his research is to translate noncoding microRNA biology to new therapeutics. Current efforts in his laboratory are directed to the investigation of (a) the mechanistic actions of microRNAs in the regulation of cancer cellular processes (e.g., drug disposition and tumor progression), and (b) novel genetically engineered noncoding RNAs as cancer therapeutics.
Dr. Yu also directs the PK/PD Bioanalytical Core Facility at UC Davis that is set up to provide bioanalytical services in support of the clinical and preclinical drug development programs. Investigators who are in need of the services may contact the facility manager directly.
Wang WP, Ho PY, Li MM, Chen QX, Addepalli B, Tu MJ, Limbach PA, Li MM, Wu WJ, Jilek JL, Qiu JX, Zhang HJ, Li T, Wun T, DeVere White R, Lam KS, Yu AM. Bioengineering novel chimeric microRNA-34a for prodrug cancer therapy: High-yield expression and purification, and structural and functional characterization. J. Pharmacol. Exp. Ther. in press (2015).
Li MM, Addepalli B, Tu MJ, Chen QX, Wang WP, Limbach PA, LaSalle JM, Zeng S, Huang M, Yu AM. Chimeric miR-1291 biosynthesized efficiently in E. coli is effective to reduce target gene expression in human carcinoma cells and improve chemosensitivity. Drug Metab Dispos. 43(7):1129-1136 (2015).
Chen QX, Wang WP, Zeng S, Uroyama S, Yu AM. A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. Nucleic Acids Res, 43(7):3857-3869 (2015).
Jiang XL, Shen HW, and Yu AM. Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors. Neuropharmacology, 89:342-351 (2015).
Li MM, Wang WP, Wu WJ, Huang M, and Yu AM. Rapid production of novel pre-microRNA agent hsa-mir-27b in Escherichia coli using recombinant RNA technology for functional studies in mammalian cells. Drug Metab Dispos. 42(11):1791-1795 (2014).
Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, and Yu AM. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291 altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis, 35(10):2264-2272 (2014).
Koh KH, Pan X, Shen HW, Yu AM, Gonzalez FJ, Isoherranen N, Zhang W, and Jeong HY. Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Bio Chem. 289(6):3105-3113 (2014).
Pan YZ, Zhou A, Hu Z, Yu AM. Small nucleolar RNA-derived microRNA hsa-miR-1291 modulates cellular drug disposition through direct targeting of ABC transporter ABCC1. Drug Metab Dispos. 41(10):1744-1751 (2013).
Jiang XL, Shen HW, Mager DE, Yu AM. Pharmacokinetic interactions between monoamine oxidase A inhibitor harmaline and 5-methoxy-N,N-dimethyltryptamine, and the impact of CYP2D6 status, Drug Metab Dispos. 41(5):975-986 (2013).
Bruno AE, Li L, Kalabus JL, Pan YZ, Yu AM, Hu ZH. miRdSNP: a database of disease-associated SNPs and microRNA target sites on 3'UTRs of human genes, BMC Genomics. 13:44 (2012).
See other publications on PubMed.