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Department of Biochemistry and Molecular Medicine

Department of Biochemistry and Molecular Medicine

PK/PD Bioanalytical Core Facility

Understanding drug metabolism (DM), pharmacokinetics (PK), and pharmacodynamics (PD) is essential for the development of new therapeutics, which requires accurate and reliable quantification of drugs/metabolites in complex biological matrix. The PK/PD Bioanalytical Core Facility at UC Davis Medical Center (UCDMC) is equipped with a Waters Xevo TQS UPLC-MS/MS system and set up to provide state-of-the-art bioanalytical services to support the clinical and preclinical drug development programs.

Services and rates:

Service  UCD Non-UCD
Blood PK (Precipitation) $34 per sample  $45 per sample
Blood/urine PK (SPE/LLE)  $62 per sample $81 per sample
New method development and validation $1500-2500 $2000-3500
Others Quotation Quotation

Team:

Dr. Aiming Yu, Director, has extensive experience in the study of DM/PK/PD and bioanalysis. His research interests include DM/PK/PD, noncoding RNA epigenetics, pharmacogenetics, and cancer therapy.
Tel: (916) 734-1566; Email: aimyu@ucdavis.edu

Dr. Jimmy Wu, Technical Manager, Assistant Project Scientist, is specialized in HPLC and LC-MS assay development. He has worked closely with UCDMC GMP facility to develop and QC drug formulations for an ongoing clinical trial at UCDMC. He also developed an LC-MS bioanalytical method for this clinical trial. Prior to this clinical research, he successfully developed a drug screening method that can discover druggable targets and their corresponding lead compounds simultaneously in a short period. He also studied on small molecule-protein and protein–protein binding kinetics with Biacore 3000. Besides analytical chemistry, Dr. Wu’s research interests include cancer research, protein chemistry, molecular biology and microbiology.
Tel: (916) 703-5510; Email: chywu@ucdavis.edu

PK/PD Bioanalytical Laboratory Advisory Board:

Dr. Lars Berglund
Dr. Kit S. Lam
Dr. Michael A. Rogawski