Yuanpei Li, Ph.D. Assistant Professor
2700 Stockton Blvd
Oak Park Research Building
Suite 2405
Sacramento Campus
Ph: 916-734-4420
e-mail

The Nanomedicine and Biomaterials Laboratory aims to 1) develop next generation nano-medicine platforms, biomaterials and microfluidic devices by learning from nature and clinical practice, 2) obtain fundamental knowledge on how these subjects interact with biological systems, and 3) apply them to solve complex medical problems that are associated with cancer and other diseases. Our research projects integrate recent advances in interdisciplinary fields, such as nanotechnology, material sciences, chemistry, engineering and biology, to create innovative technologies and therapeutics. Significant efforts have also been devoted to the rapid “bench to bed side” translation of these innovative technologies and therapeutics that can tremendously benefit the health of human and companion animals. We are particularly interested in the following research area:

  1. Targeting and programmable drug/gene delivery
  2. Theranostics
  3. New biomaterials/bio-inspired materials
  4. Integration of nanotechnology/biomaterials in microfluidics
  5. Exosomes/ oncosomes and cancer stem cells from clinical cancer patients
  6. Enabling technology for immunoengineering

Xue X, Huang Y, Wang X, Wang Z, Carney RP, Li X, He Y, Lin T, Li Y*(corresponding author), Self-Indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy, Biomaterials, 2018, 161, 203–215

Long Q, Lin T, Huang Y, Ma A, Zhang H, Carney RP, Airhart S, Lam KS, deVere White RW, Chong-xian Pan C, Li Y*(corresponding author), Imaging-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model, Nanomedicine: Nanotechnology, Biology and Medicine, 2018, 14, 789-799.

Luo Y, Wu H, Feng C, Xiao K, Yang X, Liu Q, Lin T, Zhang H, Walton JH, Ajena Y, Hu Y, Lam KS, Li Y*(corresponding author), “One-Pot” Fabrication of Highly Versatile and Biocompatible Poly(vinyl alcohol)-porphyrin-based Nanotheranostics. Theranostics, 2017, 7(16): 3901-3914

Wang Z, Qiao R, Tang N, Lu Z, Wang H, Zhang Z, Xue X, Huang Z, Zhang S, Zhang G, Li Y*(corresponding author), Active targeting theranostic iron oxide nanoparticles for MRI and magnetic resonance-guided focused ultrasound ablation of lung cancer. Biomaterials, 2017, 127, 25–35

Luo Y, Feng C, Xiao K, Yang X, Liu Q, Lin T, Zhang H, Walton JH, Ajena Y, Hu Y, Lam KS, Li Y*(corresponding author), “One-Pot” Fabrication of Highly Versatile and Biocompatible Poly(vinyl alcohol)-porphyrin-based Nanotheranostics, Theranostics, 2017, In press

Xiao W, Suby N, Xiao K, Lin T, Al Awwad N, Lam KS, Li Y*(corresponding author), Extremely long tumor retention, multi-responsive boronate crosslinked micelles with superior therapeutic efficacy for ovarian cancer. Journal of Controlled Release, 2017, In press

Yang X, Luo Y, Lin T, Zhang H, Lac D, Xiao K, Lam KS, Li Y*(corresponding author), Sub-100 nm, Long Tumor Retention SN-38-Loaded Photonic Micelles for Tri-modal Cancer Therapy. Journal of Controlled Release, 2017, 261, 297-306

Xiao K, Lin T, Lam KS, Li Y*(corresponding author), A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery. Nanoscale, 2017, 9, 7765 - 7770

Wang X, Kong D, Lin T, Li X, Izumiya Y, Ding X, Zhang L, Hu X, Yang J,  Gao S, Lam K, Li Y* (corresponding author), A versatile nanoplatform for synergistic combination therapy of esophageal cancer. Acta Pharmacologica Sinica, 2017, 38, 931–942

Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer D, Lam KS, Wang F, Wang A, Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration, ACS Chemical Biology, 2017, 12 (4), 1075-1086

Zhou F, Shimoda M, Olney L, Lyu Y, Tran K, Jiang G, Nakano K, Davis RR, Tepper CG, Maverakis E, Campbell M, Li Y, Dandekar S & Izumiya Y, Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma, Molecular Cancer Therapeutics, 2017, Accepted

He W, Felderman M, Evans AC, Geng J, Homan D, Bourguet F, Fischer Li Y, Lam KS, Noy A, Xing L, Cheng HR, Rasley A, Blanchette CD, Kamrud K, Wang N, Gouvis H, Peterson TC, Hubby B, Coleman MA, Cell-free Production of a Functional Oligomeric Form of a Chlamydia Major Outer Membrane Protein (MOMP) for Vaccine Development, Journal of Biological Chemistry, 2017, In press

Bharadwaj G, Viet Nhan V, Yang S, Li X, Narayanan A, Macarenco AA, Shi Yu, Yang D, Vieira SL, Xiao W, Li Y & Lam KS, Cholic acid-based novel micellar nanoplatform for delivering FDA-approved taxanes, Nanomedicine (London), 2017, 12(10):1153-1164

Lin T, Guo W, Long Q, Ma A, Liu Q, Zhang H, Pan C, Lam KS, Li Y* (corresponding author). HSP90 inhibitor encapsulated photo-theranostic nanoparticles for synergistic combination cancer therapy. Theranostics, 2016, 6(9), 1324-1335

Lin T/Li Y (co-first author), Liu Q, Chen J, Zhang H, Lac D, Zhang H, Ferrara KW, Wachsmann-H S, Li T, Airhart S, deVere White R, Pan C, Lam KS, Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer. Biomaterials, 2016,104, 339-351

Bharadwaj G, Lee JS, Kekessie I, Lam KS, Li Y* (corresponding author). A facile and efficient approach for production of reversible disulfide cross-linked micelles. Journal of Visualized Experiments, 2016, In Press

Pan A, Zhang H, Li Y, Lin T, Wang F, Lee J, Cheng M, Dall’Era M, Li T, deVere White R, Pan C and Lam KS, Disulfide-crosslinked nanomicelles confer cancer-specific drug delivery and improve efficacy of paclitaxel in bladder cancer. Nanotechnology, 2016, 27, 425103

Orbay H, Li Y, Xiao W, Cherry SR, Lam KS, Sahar DE, Developing a Nanoparticle-Delivered High-Efficacy Treatment for Infantile Hemangiomas Using a Mouse Hemangioendothelioma Model. Plastic and Reconstructive Surgery, 2016, 138(2), 410-417

Xiao K/Li Y (co-first author), Wang C, Ahmad S, Vu M, Kuma K, Cheng Y, Lam KS, Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer. Biomaterials, 2015, 67,183-193, PMID: 26218744

Lin T, Rodriguez CO, Li Y, Nanomedicine in Veterinary Oncology, The Veterinary Journal, 2015, 205 (2):189-197, PMID: 25862394

Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam KS, Flannery JG, Burns ME, Sarunic MV, Pugh E, Zawadzki R, Compact, wide-field multispectral SLO-OCT in vivo mouse retinal imager: system design, performance and applications, Journal of Biomedical Optics, 2015, 20(12), 126005

Chen Y, Su J, Duan L, Li Y, Liu X, Preparation of waterborne polyurethane acrylate (PUA) and application to UV-curing coatings. Journal of Chemical Science and Technology, 2015; 4(1):8-15

  • National Institutes of Health
  • Department of Defense
  • Xiangdong Xue (Postdoctoral scholar)
  • Hao Wu (Postdoctoral scholar)
  • Gaomai Yang (Postdoctoral scholar)
  • Zhao Ma (Postdoctoral scholar)
  • Yee Huang (Visiting graduate student)
  • Yixuan He (Visiting student)
  • Zhongyi (Johnny) Huang (Undergraduate)
  • Zicheng Zhao (Undergraduate)