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Department of Biochemistry and Molecular Medicine

Department of Biochemistry and Molecular Medicine

Kit S. Lam, M.D., Ph.D.

Kit S. Lam, M.D., Ph.D.

Professor and Chair
Oak Park Research Building, Sacramento Campus
Ph: (916) 734-0910
e-mail

Recent/Current
Research Funding

National Institutes of Health

Department of Defense

Graduate Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Biomedical Engineering

Comparative Pathology

Clinical Research

Genetics

Immunology

Pharmacology and Toxicology

Laboratory Personnel

Urvashi Bhardwaj, Ph.D.

Research Interests

For more information, visit the Kit Lam Laboratory website.

Dr. Lam is an expert in combinatorial chemistry, chemical biology, drug development, molecular imaging, nanotherapeutics and medical oncology. His laboratory is engaged in the development and application of combinatorial library methods for basic research and drug discovery. In addition to cancer drug development, he is also interested in signal transduction, antibiotics development, molecular immunology, chemical microarray, and proteomics. Dr. Lam is both a practicing medical oncologist and a laboratory investigator. He is distinguished for revolutionizing cancer diagnosis and treatment and is acclaimed for his pioneering role in the field of combinatorial chemistry and developing the novel one-bead-one-compound technology, which rapidly screens millions of chemicals at one time to identify those that bind to diseased cells. The tool is advancing the early detection and precise delivery of treatments for brain, breast, prostate, pancreatic, lymphoma and other cancers. In addition, it is advancing the discovery of imaging agents that produce highly detailed molecular profiles of diseases for improved diagnosis and tracking medication effectiveness. His development and applications of combinatorial chemistry and other chemical methods look to solve many biomedical problems. Dr. Lam invented the “one-bead-one-compound” (OBOC) combinatorial library method, filed the patents (The basic patents on the OBOC technology was issued in 1996, 1997, and 1999 by the US patent office), and published the technique in Nature in 1991. This represents one of the first few reports in the new field of combinatorial chemistry at the time. Since then, the field of combinatorial chemistry has rapidly evolved into a new chemistry discipline, and four scientific journals are now devoted to this field (J of Combinatorial Chemistry, Combinatorial Chemistry and Highthroughput Screening, Molecular Diversity, and QSAR Combinatorial Science). Combinatorial chemistry has become an indispensable tool in drug development and chemical research. The OBOC combinatorial library approach is unique and truly an ultra-high throughput method, as thousands to millions of chemical compounds (peptides, peptidomimetics, small molecules, and macrocyclic natural product like molecules) can be efficiently synthesized and screened in parallel in a relatively short time. Combinatorial chemistry has also provided strong impetus for the new field of “chemical genetics”.

In addition to expanding the use of one-bead-one-compound technology, Dr. Lam's research also includes developing a blood test for ovarian-cancer detection, utilizing nanoparticle carriers for drug delivery and synthesizing cancer-fighting molecules with less-toxic side effects. He is currently collaborating on projects to identify the molecular pathogenesis of and treatments for primary biliary cirrhosis, osteoporosis and Alzheimer's disease.

 

Representative Publications

Hua S, Saunders M, Dimapasoc L, Jeong SH, Kim S, So M, Lee KS, Jae H, Lam KS, Lebrilla C, An HJ. Diferentiation of cancer cell origin and molecular subtype by plasma membrane N-glycan profiling. Journal of Proteome Research, 13: 961-968,  2014. (PMID 24303873)

Li Y, Xiao K, Zhu W, Deng W, Lam KS. Stimuli-response cross-linked micelles for on-demand dr7g delivery against cancers. Adv Drug Deliv Rev. 66c: 58-73, 2014. (PMID 24060922).

Garland SP, Wang RY, Raghunathan VK, Lam KS, Murphy CJ, Russell P, Sun G, Pan T. Photopatternable and photoactive hydrogel for on-demand generation of hydrogen peroxide in cell culture. Biomaterials. 35: 1762-1770, 2014 (PMID: 24290809)

Sun YS, Luo J, Lam KS, Zhu XD. Detection of formation and disintegration of micelles by oblique-incidence reflectivity difference microscopy. Instrument Science and Technology. 41: 545-555, 2013.

Xiao K, Suby N, Li Y, and Lam KS. Telodendrimer-based nanocarriers for the treatment of ovarian cancer. Therapeutic Delivery. In press, October 2013.

Kenyon NJ, Bratt JM, Lee J, Luo J, Franzi LM, Zeki AA, and Lam KS. Self-ssembling nanoparticles contiqning dexamethasone as a novel therapy in allergic airway inflammation. PLOS ONE, in press, 2013.

Jialal I, Devaraj S, Smith G, Lam K, Kumaresan P. A novel peptide inhibitor attenuates C-reactive protein’s pro-inflammatory effects in vivo. International Journal of Cardiology, in press, 2013.

Guo W, Liu R, Bhardwaj G, Ma A, Changou C, Yang JC, Li Y, Feng C,Luo Y, Mazloom A, Sanchez E, Wang Y, Huang W, Patterson R, Evans CP, Lam KS, Kung H. CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostrate cacner cells and overcomes resistance to Src inhibitors. PLOS ONE, in press, 2013.

Yao W, Guan M, Jia J, Dai W, Lay YE, Amugongo S, Liu R, Olivos D, Saunders M, Lam KS, Nolta J, Olvera D, Ritchie RO, and Lane NE. Reversing bone loss by directing mesenchymal stem cells to the bone. Stem Cells. In press, 2013.

He W, Luo J, Bourguet F, Xing L, Yi SK, Gao T, Blanchetter C, Henderson PT, Kuhn E, Malfatti M, Murphy WJ, Cheng RH, Lam KS, Coleman MA. Controlling the diameter, monodispersity, and solubility of ApoA1 nanolipoprotein particles using telodendrimer chemistry. Protein Sci. 2013.

Huang W, Shi C, Shao Y, Lam KS, and Luo J. The core-inversible micelles for hydrophilic drug delivery. Chem Commun (Camb), 49: 6674-6676, 2013.

Ding Y, Huang E, Lam KS, and Pan T. Microfluidic impact printer with interchangeable cartridges for versatile non-contact multiplexed micropatterning. Lab Chip, 13: 1902-1910, 2013.

Xiao W, Bononi FC, Townsend J, Li Y, Liu R, Lam KS. Immobilized OBOC combinatorial bead array to facilitate multiplicative screening. Comb Chem High Throughput Screen. 16: 441-448, 2013.

Malekan H, Fung G, Thon V, Khedri Z, Yu H, Qu J, Li Y, Ding L, Lam KS, Chen X. One-pot multi-enzyme (OPME) chemoenzymatic synthesis of sialyl-Tn-MUC1 and sialyl-T-MUC1 glycopeptides containing natural or non-natural sialic acid. Bioorganic and Medicinal Chemistry. 2013.

Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, and Gershwin ME. Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun. 41: 79-86, 2013.

Kumaresan P, Devaraj S, Huang W, Lau E, Liu R, Lam KS, and Jialal I. Synthesis and Characterization of a Novel Inhibitor of CRP-mediated Pro-Inflammatory Effects. Metabolic Syndrome and Related Disorders. 11: 177-184, 2013.

Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc, 40: 939-943, 2013.

Ye L, Dickerson T, Kaur H, Takada YK, Fujita M, Liu R, Knapp JM, Lam KS, Schore NE, Kurth MJ, Takada Y. Identificaiton of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3. Bioorganic & Medicinal Chemistry Letters. 23: 350-345, 2012.

Duru N, FanM, Candas D, Menaa C, Liu HC, Nantajit D, Wen Y, Xiao K, Eldridge A,Chromy BA, Li S, Spitz DR, Lam KS, Wicha MS, Li JJ. HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells. Clin Cancer Res. 18:6634-6647, 2012.

Li YP, Budamagunta M, Luo J, Xiao W, Voss J, and Lam KS. Probing of the Assembly Structure and Dynamics within Nanoparticles during Interaction with Blood Proteins. ACS Nano, 6:9485-9489, 2012.

Lee J, and Lam KS. Perspectives on Clinical Translation of Smart Nanotherapeutics. Therapeutic Delivery: Special issue on "Intelligent Drug Design" 3: 1359-1362, 2012.

Lin T, Li Y, Zhang H, Luo J, Good win N, Gao T, deVere White R, Lam KS, Pan CX. Tumor-targeting multifiunctional micelles for imaging and chemotherapy of advanced bladder cancer. Nanomedicine, 2012, in press.

Wu M, Piccini M, Koh CY, Lam KS, Singh AK. Single cell microRNA analysis using microfluidic flow cytometry. PLOS One, 2012, in press.

Leung PS, Lam K, Kurth MJ, Coppel RL, Gerhswin ME. Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? Trends Mol Med. 18: 577-582, 2012.

Guo W, Liu R, Ono Y, Ma AH, Martinez A, Sanchez E, Wang Y, Huang W, Mazloom A, Li J, Ning J, Maverakis E, Lam KS, Kung HJ. Molecular characteristics of CTA056, a novel Itk inhibitor which selectively targets malignant T cells and modulates oncomirs. Mol Pharmacol. 82: 938-47, 2012 (PMID: 228998868).

Shaheen F, Rizvi TS, Musharraf SG, Ganesan A, Xiao K, Townsend JB, Lam KS, Choudhary MI. Solid-phase total synthesis of cherimolacyclopeptide E and discovery of more potent analogues by alanine screening. J Nat Prod. Nov 13, 2012.

Lin TY, Zhang H, Luo J, LiY, Gao T, Lara PN Jr, deVere White R, Lam KS, Pan CX. Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. Int J Nanomedicine. 7:2793-2804, 2012.

Hu X, Kheirolomoom A, Mahakian LM, Beegle JR, Kruse DE, Lam KS, Ferrara KW. Insonation of targeted microbubbles produces regions of reduced blood flow within tumor vasculature. Invest Radiol. 47: 398-405, 2012.

Kato J, Li Y, Xiao K, Lee J, Luo J, Tuscano J, O’Donnell R, Lam KS. Disulfide cross-linked micelles for the targeted delivery of vincristine to B-cell lymphoma. Molecular Pharmaceutics. 9: 1727-1735, 2012. (PMID: 22530955)

Zwingenberger AL, Kent MS, Liu R, Kukis DL, Wisner ER, DeNardo SJ, Taylor SL, and Lam KS. In vivo biodistribution and safety of 99mTc-LLP2A-Hynic in canine non-Hodgkin’s lymphoma. PLos One, 7(4):e34404, 2012.

Zwingenberger AL, Kent MS, Shi C, Taylor SL, Chen X, and Lam KS. Affinity of the alpha4-beta1 integrin-targeting peptide LLP2A to canine lymphoma. Veterinary Immunology and Immunopathology. 145: 298-304, 2012. (PMDI: 22177114)

Xiao K, Li Y, Lee JS, Gonik AM, Dong T, Fung G, Sanchez E, Xing L, Cheng HR, Luo J, and Lam KS. "OA02" Peptide Facilitates the Precise Targeting of Paclitaxel-Loaded Micellar Nanoparticles to Ovarian Cancer In Vivo. Cancer Research. 72(8): 2100-2110, 2012. (PMID: 22396491)

Skokeen M, Zheleznyak A, Wilson JM, Jiang M, Liu R, Ferdani R, Lam KS, Schwarz, Anderson CJ. Molecular imaging of very late antigen-4 (α41 integrin) in the pre-metastatic niche. The Journal of Nuclear Medicine, 53: 779-786, 2012. (PMDI 22496586)

Zhang H, Luo J, Li Y, Henderson PT, Wang Y, Wachsmann-Hogiu S, Zhao W, Lam KS, Pan C. Characterization of high-affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine. In press, 2012. (PMDI: 22197725)

Xiao W, Luo J, Jian T, Riggs J, Tseng H, Henderson PT, Cherry S, Rowland D, and Lam KS. The biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nano-formulation in an ovarian cancer mouse xenograft model. International Journal of Nanomedicine. 7: 1587-1597, 2012.

Li Y, Xiao W, Xiao K, Berti L, Luo J, Tseng HP, Gung G, and Lam KS. Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to acidic pH and cis-Diols. Angewandte Chemie Int Ed Engl. 51: 2864-2869, 2012. (PMID: 22253091)

Lin T, Zhang H, Luo J, Li Y, Gao T, Lara PN, de Vere White R, Lam KS, and Pan CX. Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. International Journal of Nanomedicine. 7: 2793-2804, 2012.

Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, Ranganiban B, Meng L, Zhou P, Shahnazari M, Ritchie RO, and Lane NE. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nature Medicine. 18: 456-462, 2012. (PMID: 22306732)

Aina OH, Maeda Y, Harison M, Zwingenberger AL, Walker NJ, Lam KS, and Kent MS. Canine malignant melanoma alpha-3 integrin binding peptides. Vet immunol immunopathol. 143:11-19, 2011. (PMID: 21722969)

Naiyanetr P, Butler JD, Meng L, Pfeiff J, Kenny TP, Guggenheim KG, Reiger R, Lam KS, Kurth MJ, Ansari AA, Coppel RL, Lopez-Hoyos M, Gershwin ME, Leujng PSC. Electrophile-Modified Lipoic Derivatives of PDC-E2 Elicits Anti-mitochondrial Antibody Reactivity. Journal of Autoimmunity. 37:209-216, 2011.

Yao N, Chen CY, Wu CY, Motonishi K, Kung HJ, Lam KS. Novel flavonoids with anti-proliferative activities against breast cancer cells. J of Medicinal Chemistry, 54: 4339-4349, 2011.

Xiao K, Luo J, Li Y, Lee JS, Fung G, Lam KS. PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma. Journal of Controlled Release. 155: 272-281, 2011.

Li Y, Xiao K, Luo J, Xiao W, Lee JS, Gonik AM, Kato J, Dong T, and Lam KS. Well-defined, Reversible Disulfide Cross-linked Micelles for On-demand Paclitaxel Delivery. Biomaterial. 32: 6633-6645, 2011.

Shi L, Fleming CJ, Riechers SL, Yin NN, Luo J, Lam KS, Liu GY. High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy. Journal of Drug Delivery. Jun13. 2011.

Kawano M, Xing L, Hand H, Miyamura T, Barnett S, Srivastava I, Lam KS, Cheng H. Design platforms of nanocapsules for human therapeutics or vaccines. In Development of Vaccines, from discovery to clinical testing, ed Singh M and Srivastava I. Wiley, pp125-140, 2011, 2011.

Chang PC, Fitzgerald LD, Hsia DA, Izumiya Y, Wu CY, Hsieh WP, Lin SF, Campbell M, Lam KS, Luciw PA, Tepper CG, Kung HJ. Histone demethylase JMJD2A regulates KSHV replication and is targeted by a viral transcriptional factor. J Virol. 85: 3283-3293, 2011.

Ding Y, Hong L, Nie B, Lam KS, Pan T. Capillary-driven automatic packaging. Lab on a Chip. 11: 1464-1469, 2011.

Xiao K, Li Y, Luo J, Lee JS, Xiao W, Gonik AM, Agarwal RG, Lam KS. The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials. 32: 3435-3446, 2011.

Kumaresan P, Wang Y, Saunders M, Maeda Y, Wang X, Liu R, Lam KS. Rapid Discovery of Death Ligands with One-Bead-Two-Compound Combinatorial Library Methods. Journal of Combinatorial Sciences. 13: 259-264, 2011.

Li J, Liu R, Lam KS, Jin LW, Duan Y. Alzheimer’s disease drug candidates stabilize A-beta protein native structure by interacting with the hydrophobic core. Biophysical Journal. 100: 1076-1082, 2011.

 

Recent/Current Teaching

Upper division courses
  • 192 Internship in Biological Chemistry
  • 198 Group Study
  • 199 Special Study for Advanced Undergraduates
Graduate courses
  • 298 Group Study
  • 299 Research
Professional courses for medical students
  • 410A Molecular and Cell Biology
  • 410B Cell Biology and Metabolism
  • 414 Molecular Medicine
  • 491 Human Genetics Seminar
  • 497 Tutoring in Biological Chemistry
  • 498 Group Study
  • 499 Research

 

Honors and Awards

  • 2008 Fellow of American College of Physicians
  • 2009 “Above and Beyond Mentor Award” from the Center for Biophotonics Science and Technology at UC Davis
  • 2010 Harold Albin Johnson endowed Chair in Biomedical Research.