Dr. Chen's research includes molecular mechanisms of hormone signaling in control of cell growth and differentiation, role of steroid receptors such as estrogen receptors and androgen receptor and their associated cofactors (especially coactivators) in cancer. Chromatin Modifications and Remodeling Dr. Chen is also researching on chromatin modifications/ remodeling and protein acetylation in control of gene expression. His long-term objectives are (1) to determine the role of nuclear receptor coactivators in hormone-mediated control of cell growth, differentiation and homeostasis both in normal and tumor cells and (2) to elucidate chromatin modification/remodeling as a regulatory mechanism in hormone signaling and cell proliferation.
Zou JX, Zhong Z, Shi XB, Tepper CG, deVere White RW, Kung HJ, Chen HW. ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes. Prostate, 2006. 66(14): 1474-1486.
Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shi HM, Shi XB, deVere White RW, Chen HW, Tepper CG, Kung HJ. Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells. Cancer Research, 2006. 66(17): 8439-8447.
Desai SJ, Ma AH, Tepper CG, Chen HW, Kung HJ. Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications. Cancer Research, 2007. 66(21): 10449-10459.
Li LB, Louie MC, Chen HW, Zou JX. Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression.. Cancer Lett, 2008. 261(1): 64-73.
Shi XB, Xue L, Zou JX, Gandour-Edwards R, Chen HW, Devere White RW. Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen- independent growth of prostate cancer cells.. Prostate, 2008 68(16): 1816-1826.
Zou JX, Guo L, Revenko AS, Tepper CG, Gemo AT, Kung HJ, Chen HW. Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer.. Cancer Research, 2009. 69(8): 3339-46.
Qin L, Liu Z, Chen HW, Xu J. The Steroid Receptor Coactivator-1 (SRC-1) Regulates Twist Expression and Promotes Breast Cancer Metastasis.. Cancer Research, 2009. 69(9): 3819-27.
Upper Division Courses
- 199 Special Study for Advanced Undergraduates
Professional Courses for Medical Students
- BCM299 Research
- MCB257 Cell Proliferation and Cancer Genes
- BCM410A Medical Biochemistry
- BCM410B Cell Biology and Metabolism