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Department of Biochemistry and Molecular Medicine

Department of Biochemistry and Molecular Medicine

Kermit L. Carraway, III, Ph.D.

Kermit L. Carraway, III, Ph.D.

Professor
Rm 1400 Research III Building
Sacramento Campus
Ph: (916)734-3114
Fax: (916) 734-0190
e-mail

Recent/Current
Research Funding

National Institutes of Health

DoD Breast Cancer Research Program

Komen for the Cure

Graduate Group Affiliations

Biochemistry, Molecular,
Cellular and
Developmental Biology

Pharmacology and Toxicology

Research Interests

The lab uses biochemical, cell biological, pharmacological and genetic methods to dissect the roles of growth factors, their receptors and modulator proteins in mammalian development and in tumor initiation and progression. We are particularly interested in mechanisms of receptor ubiquitination and degradation, and how these processes impact the receptor overexpression that drives the malignancy of breast and brain tumors.

 

Representative Publications

Carraway, K.L., III, Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann, M., and Lai, C. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 1997. 387, 512-516. PMID 9168115

Ghiglione, C., Carraway, K.L. III, Amundadottir, L.T., Boswell, R.E., Perrimon, N. and Duffy, J.B. The transmembrane molecule Kekkon-1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell 1999. 96, 847-856. PMID 10102272

Wu, X., Yen, L., Irwin, L., Sweeney, C., and Carraway, K. L., III. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol. Cell. Biol. 2004. 24, 7748-7757. PMID 15314180

Yen, L., Cao, Z., Wu, X., Ingalla, E. R., Baron, C., Young, L. J., Gregg, J. P., Cardiff, R. D., Borowsky, A. D., Sweeney, C., and Carraway, K. L., III. Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res. 2006. 66, 11279-11286. PMID 17145873

Ballif, B. A., Cao, Z., Schwartz, D., Carraway, K. L., III, and Gygi, S. P. Identification of 14-3-3epsilon substrates from embryonic murine brain. J Proteome 2006. Res 5, 2372-2379. PMID 16944949

Cao, Z., Wu, X., Yen, L., Sweeney, C. and Carraway, K.L. III. Neuregulin induced ErbB3 down-regulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol 2007. 27, 2180-2188. PMID 17210635

Miller, J.K., Shattuck, D.L., Ingalla, E.Q., Yen, L., Borowsky, A.D., Young, L.J., Cardiff, R.D., Carraway, K.L., III, and Sweeney, C. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. Cancer 2008. Res. 68, 8286-8294. PMID 18922900

Workman, H.C., Sweeney, C., and Carraway, K.L., III. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer 2009a. Res. 69, 2845-2852. PMID 19293191

Workman, H.C., Miller, J.K., Ingalla, E.Q., Kaur, R.P., Yamamoto, D.I., Beckett, L.A., Young, L.J., Cardiff, R.D., Borowsky, A.D., Carraway, K.L., Sweeney, C., and Carraway, K.L., III. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast 2009b. 11, R70. PMID 19761616

 

Recent/Current Teaching

Upper Division Courses
  • 199 Special Study for Advanced Undergraduates
Graduate Courses
  • BCM299 Research
  • MCB257 Cell Proliferation and Cancer Genes
Professional Courses for Medical Students
  • BCM410A Medical Biochemistry
  • BCM410B Cell Biology and Metabolism