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Department of Anesthesiology and Pain Medicine

Department of Anesthesiology and Pain Medicine

Research

Departmental faculty, under the leadership of Peter G. Moore, Professor and Chair of the Department of Anesthesiology, are engaged in a variety of clinical and basic science research.

At the UC Davis Department of Anesthesiology & Pain Medicine, the main research areas are:

  • Malignant Hyperthermia
  • Congenital Myasthenic Syndromes: Pathogenic Mechanisms
  • Calcium-Dependent Modulation of Pancreatic b-Cell Cardiac ATP-Sensitive Potassium Channels
  • Role of Eicosanoids in Cardiac Injury after Myocardial Infarction
  • A Novel Approach to the Treatment of Sacroiliac Joint Pain:  Bipolar Radiofrequency Ablation Applied in a Palisade Pattern
  • Disease management model that uses teleconference technology to connect specialist teams with primary care provider teams to co-manage patients with complex health conditions. 

Clinical research takes place at the UC Davis Medical Center in Sacramento where faculty are engaged in pain-related research. Basic science research is carried out on the main UC Davis campus, including the Anesthesia Research Laboratories, Center for Neuroscience and the Membrane Biology Research Laboratories.

Extramural funding sources for the department include the National Institutes of Health (General Medical Sciences). Intramural funding is through the UC Davis School of Medicine.

A few of our active research projects are listd below:

  • The Effect of Perioperative Medications on the Outcomes of Patients Undergoing Cardiac Surgery
    The specific aim of this study is to retrospectively investigate whether perioperative medication use is associated with decreases in the incidence of postoperative cardiovascular complications in patients undergoing elective cardiac surgery.
    Team member:  Hong Liu
  • Factors Affect Outcomes in Cardiovascular Surgery
    The goals of this study: 1. Identify factors that contribute to perioperative morbidity and mortality in patients undergoing cardiac surgery that involves cardiopulmonary bypass. 2. Identify factors that improve perioperative morbidity and mortality in patients undergoing cardiac surgery
    Team members: Dustin Dayton, Jasper Labelle, Rajika Nanayakkara, De-An Zhang and Hong Liu.
  • Parental Experience with Oral Midazolam Premedication
    Team Member:  Ken Furukawa
  • A Novel Approach to the Treatment of Sacroiliac Joint (SIJC) Pain:  Bipolar Radiofrequency Ablation Applied in a Palisade Pattern
    Bipolar radiofrequency ablation (RFA), an interventional pain procedure in which an electrical current is used to ablate nerves, has emerged as a potential treatment for SIJC pain.  This retrospective chart review evaluates if the application of RF electrodes in a palisade pattern using bipolar technology to ablate the S1, S2, S3 sacral lateral branch nerves and L5 medial branch nerve is an effective and safe treatment for SIJC pain.
    Team members: Naileshni Singh, Samir Sheth,  Damoon Rejaei,  Ian Koebner, and Scott Fishman
  • Evaluation of the Masimo Continuous Hemoglobin Monitor with Polar Plot Methodology
    This is an analysis of the errors in the continuous Hgb measurement technology to create a model that improves the curve fit and then demonstrated the impact of the revisions using the methodology for comparison of coutinuous monitors as recently described by Critchley.
    Team members: Neal Fleming and Andy Zhang
  • Effect of Alveolar Minute Ventilation on Respiratory Gas Heat Content
    Evaluation of the impact of changes in Tidal volume on respiratory heat content as part of a series of protocols evaluating the impact of this new monitoring system
    Team members: Neal Fleming, David Rose, and Bonnie Lee
  • North American Malignant Hyperthermia Registry
    This is a multi-center, multi-year, ongoing research study, with no pre-determined end date.   The purpose of the study is to establish and maintain a central database containing the names and pertinent information of patients with a history of Malignant Hyperthermia (MH) and similar syndromes.  With the permission of participants, the Principal Investigator will provide pre-determined data to the North American Malignant Hyperthermia Registry (NAMHR).  The NAMH Registry will maintain the database of information collected from the 5 Malignant Hyperthermia Biopsy Centers throughout the United States.  The University of California, Davis is 1 of 5 national Malignant Hyperthemia Biopsy Centers.
    Team member: Timothy Tautz
  • Simulation for the Interventional Pain Management Setting
    We have developed a simulation based platform for the training of pain interventionalists in the management of crisis resource algorithms.
    Team members: Naileshni Singh, David Copenhaver, Samir Sheth, Chin-Shang Li, and Scott Fishman  
  • Does Video-Assisted Self-Review Help Students Learn a New Skill Faster
    Laryngoscopy is an essential skill that anesthesiology residents and medical students must master as quickly as possible. Most students learn and practice laryngoscopy techniques on mannequins, however, most agree that this is not really very similar to intubating patients. Some investigators have examined the utility of videolaryngoscopy to facilitate training in the mannequins, but no one has extended this approach to evaluate its impact on the training of students in clinical practice.  This protocol is designed to determine if  the evaluating the procedure by reviewing video recordings with a coach (like professional athletes review their performance after their games) will help subjects master laryngoscopy skills faster while reducing morbidities (lip damage, dental damage, airway emergencies, etc)..  Team member:  Neal Fleming