Skip to main content
Center for Tissue Regeneration and Repair

Center for Tissue Regeneration and Repair

A. Hari Reddi

Professor Ellison Chair of Orthopaedic Research Orthopedics (Med)
UC Davis Medical Center / UC Davis School of Medicine
(916) 734-3311
ahreddi@ucdavis.edu
Ph.D. - Endocrinology and Physiology of Reproduction - 1966

Tissue Engineering

Research intertests

  1. Cellular and molecular basis of cartilage repair and osteoarthritis.
  2. Fracture healing and stem cells for regeneration in nonunions.
  3. Tissue engineering of bone and cartilage based on biomaterials and biotechnology.
  4. Role of extracellular matrix and growth factors in cell differentiation and morphogenesis of bone and cartilage.
  5. Hormonal regulation of cartilage, bone, and bone marrow development.

Graduate group affiliations

  • Cell and Developmental Biology
  • Biochemistry and Molecular Biology

Recent publications

  • Nakagawa T, Lee SY, Reddi AH 
    Induction of chondrogenesis from human embryonic stem cells without embryoid body formation by bone morphogenetic protein 7 and transforming growth factor beta1
    Arthritis Rheum. 2009 Dec;60(12):3686-92
  • Reddi AH, Reddi A 
    Bone morphogenetic proteins (BMPs): from morphogens to metabologens
    Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. Epub 2009 Nov 8
  • Lee SY, Nakagawa T, Reddi AH 
    Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering: analysis of superficial zone protein/lubricin expression
    Tissue Eng Part A. 2010 Jan;16(1):317-25
  • Dunn W, DuRaine G, Reddi AH 
    Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction
    Arthritis Rheum. 2009 Aug;60(8):2333-9
  • Kishimoto KN, Oxford CL, Reddi AH 
    Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia
    Cell Biol Int. 2009 Dec;33(12):1222-9. Epub 2009 Jun 12
  • Ryan JA, Eisner EA, DuRaine G, You Z, Reddi AH. 
    Mechanical compression of articular cartilage induces chondrocyte proliferation and inhibits proteoglycan synthesis by activation of the ERK pathway: implications for tissue engineering and regenerative medicine.
    J Tissue Eng Regen Med. 2009 Feb;3(2):107-16.
  • Lee SY, Nakagawa T, Reddi AH. 
    Induction of chondrogenesis and expression of superficial zone protein (SZP)/lubricin by mesenchymal progenitors in the infrapatellar fat pad of the knee joint treated with TGF-beta1 and BMP-7.
    Biochem Biophys Res Commun. 2008 Nov 7;376(1):148-53. Epub 2008 Sep 5.
  • Lee SY, Niikura T, Reddi AH. 
    Superficial zone protein (lubricin) in the different tissue compartments of the knee joint: modulation by transforming growth factor beta 1 and interleukin-1 beta.
    Tissue Eng Part A. 2008 Nov;14(11):1799-808.
  • Neu CP, Komvopoulos K, Reddi AH. 
    The interface of functional biotribology and regenerative medicine in synovial joints.
    Tissue Eng Part B Rev. 2008 Sep;14(3):235-47.
  • Tseng SS, Lee MA, Reddi AH. 
    Nonunions and the potential of stem cells in fracture-healing.
    J Bone Joint Surg Am. 2008 Feb;90 Suppl 1:92-8. Review.
  • Yamane S, Reddi AH. 
    Induction of chondrogenesis and superficial zone protein accumulation in synovial side population cells by BMP-7 and TGF-beta1.
    J Orthop Res. 2008 Apr;26(4):485-92.
  • Niikura T, Reddi AH. 
    Differential regulation of lubricin/superficial zone protein by transforming growth factor beta/bone morphogenetic protein superfamily members in articular chondrocytes and synoviocytes.
    Arthritis Rheum. 2007 Jul;56(7):2312-21.
  • Hattori S, Oxford C, Reddi AH. 
    Identification of superficial zone articular chondrocyte stem/progenitor cells.
    Biochem Biophys Res Commun. 2007 Jun 22;358(1):99-103. Epub 2007 Apr 30.
  • Khalafi A, Schmid TM, Neu C, Reddi AH. 
    Increased accumulation of superficial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein-7 and growth factors.
    J Orthop Res. 2007 Mar;25(3):293-303.
  • Niikura T, Hak DJ, Reddi AH. 
    Global gene profiling reveals a downregulation of BMP gene expression in experimental atrophic nonunions compared to standard healing fractures.
    J Orthop Res. 2006 Jul;24(7):1463-71.
  • Reddi AH. 
    Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage.
    Arthritis Res Ther. 2006;8(1):101.
  • Reddi AH. 
    BMPs: from bone morphogenetic proteins to body morphogenetic proteins.
    Cytokine Growth Factor Rev. 2005 Jun;16(3):249-50
  • Reddi AH. 
    Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration.
    Ann Rheum Dis. 2003 Nov;62 Suppl 2:ii73-8. Review.
  • Nakashima M, Reddi AH. 
    The application of bone morphogenetic proteins to dental tissue engineering.
    Nature Biotechnology. 2003 Sept; 21(9):1025-1032.
  • Okubo Y, Reddi AH. 
    Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy.
    Biochem Biophys Res Commun. 2003 Jun 20;306(1):186-90.
  • Vinall RL, Lo SH, Reddi AH. 
    Regulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton.
    Exp Cell Res. 2002 Jan 1;272(1):32-44.
  • Vinall RL, Reddi AH. 
    The effect of BMP on the expression of cytoskeletal proteins and its potential relevance.
    J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S63-9. Review. No abstract available.
  • Reddi AH. 
    Bone morphogenetic proteins: from basic science to clinical applications.
    J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S1-6. Review. No abstract available.
  • Reddi AH. 
    Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN.
    Arthritis Res. 2001;3(1):1-5. Review.

Other publications

Reddi AH. Initiation and promotion of endochrondral bone formation by bone morphogenetic proteins: potential implications for avian tibial dyschondroplasia. Poult. Sci. 2000 Jul;79:978-81.

Ripamonte U, Van Den Heever B, Crooks J, Tucker MM, Sampath TK, Rueger DC, Reddi AH. Long-term evaluation of bone formation by osteogenic protein 1 in the baboon and relative efficacy of bone-derived bone morphogenetic proteins delivered by irradiated xenogeneic collagenous matrices. J Bone Miner Res. 2000 Sep;15(9):1798-809.

Reddi AH. Bone morphogenetic proteins and skeletal development: the kidney-bone connection. Pediatr Nephrol 2000; 14:598-601.

Reddi AH. Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside. Biochem Soc Trans 2000; 28:345-349.

Wurzler KK, DeWeese TL, Sebald W, Reddi AH. Radiation-induced impairment of bone healing can be overcome by recombinant human bone morphogenetic protein-2. J Craniofac Surg 1998; 9:131-7.

Thomas R, Anderson WA, Raman V, Reddi AH. Androgen-dependent gene expression of bone morphogenetic protein 7 in mouse prostate. Prostate 1998; 37:236-45.

Reddi AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 1998; 16:247-52.

Reddi AH. Cartilage-derived morphogenetic proteins and cartilage morphogenesis. Microsc Res Tech 1998; 43:131-6.

Reddi AH. Initiation of fracture repair by bone morphogenetic proteins. Clin Orthop 1998:S66-72.

Mont MA, Jones LC, Einhorn TA, Hungerford DS, Reddi AH. Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors. Clin Orthop 1998:S314-35.

Sires BS, Holds JB, Kincaid MC, Reddi AH. Osteogenin-enhanced bone-specific differentiation in hydroxyapatite orbital implants. Ophthal Plast Reconstr Surg 1997; 13:244-51.

Ripamonti U, Reddi AH. Tissue engineering, morphogenesis, and regeneration of the periodontal tissues by bone morphogenetic proteins. Crit Rev Oral Biol Med 1997; 8:154-63.

Reddi AH. Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens. Cytokine Growth Factor Rev 1997; 8:11-20.

Reddi AH. Bone morphogenesis and modeling: soluble signals sculpt osteosomes in the solid state [comment]. Cell 1997; 89:159-61.

Reddi AH. BMPs: actions in flesh and bone [news]. Nat Med 1997; 3:837-9.

Lietman SA, Yanagishita M, Sampath TK, Reddi AH. Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1 (bone morphogenetic protein-7). J Bone Joint Surg Am 1997; 79:1132-7.

Faucheux C, Ulysse F, Bareille R, Reddi AH, Amedee J. Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation. Biochem Biophys Res Commun 1997; 241:787-93.

Ballock RT, Heydemann A, Izumi T, Reddi AH. Regulation of the expression of the type-II collagen gene in periosteum- derived cells by three members of the transforming growth factor-beta superfamily. J Orthop Res 1997; 15:463-7.

Ripamonti U, Van Den Heever B, Sampath TK, Tucker MM, Rueger DC, Reddi AH. Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors 1996; 13:273-89.

Reddi AH. BMP-1: resurrection as procollagen C-proteinase [comment]. Science 1996; 271:463.

Khouri RK, Brown DM, Koudsi B, et al. Repair of calvarial defects with flap tissue: role of bone morphogenetic proteins and competent responding tissues. Plast Reconstr Surg 1996; 98:103-9.

Kang Y, Reddi AH. Identification and cloning of a novel type I serine/threonine kinase receptor of the TGF-beta/BMP superfamily in rat prostate. Biochem Mol Biol Int 1996; 40:993-1001.

Reddi AH. Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Maureen Owen revisited. Clin Orthop 1995:115-9.

Reddi AH, Takita H. [Initiation of bone formation cascade by bone morphogenetic proteins]. Tanpakushitsu Kakusan Koso 1995; 40:467-74.

Reddi AH. Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix. Matrix Biol 1995; 14:599-606.

Nelson JB, Hedican SP, George DJ, et al. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med 1995; 1:944-9.

Cunningham NS, Jenkins NA, Gilbert DJ, Copeland NG, Reddi AH, Lee SJ. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3. Growth Factors 1995; 12:99-109.

Breitbart AS, Staffenberg DA, Thorne CH, et al. Tricalcium phosphate and osteogenin: a bioactive onlay bone graft substitute. Plast Reconstr Surg 1995; 96:699-708.

Vukicevic S, Latin V, Chen P, Batorsky R, Reddi AH, Sampath TK. Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: high affinity binding to basement membranes. Biochem Biophys Res Commun 1994; 198:693-700.

ten Dijke P, Yamashita H, Sampath TK, et al. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem 1994; 269:16985-8.

Stevenson S, Cunningham N, Toth J, Davy D, Reddi AH. The effect of osteogenin (a bone morphogenetic protein) on the formation of bone in orthotopic segmental defects in rats. J Bone Joint Surg Am 1994; 76:1676-87.

Ripamonti U, Reddi AH. Periodontal regeneration: potential role of bone morphogenetic proteins. J Periodontal Res 1994; 29:225-35.

Ripamonti U, Heliotis M, van den Heever B, Reddi AH. Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus) [published erratum appears in J Periodontal Res 1995 Mar;30(2):149-51]. J Periodontal Res 1994; 29:439-45.

Reddi AH. Symbiosis of biotechnology and biomaterials: applications in tissue engineering of bone and cartilage [see comments]. J Cell Biochem 1994; 56:192-5.

Reddi AH. Bone and cartilage differentiation. Curr Opin Genet Dev 1994; 4:737-44.

Nakashima M, Nagasawa H, Yamada Y, Reddi AH. Regulatory role of transforming growth factor-beta, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differentiation of dental pulp cells. Dev Biol 1994; 162:18-28.

Luyten FP, Chen P, Paralkar V, Reddi AH. Recombinant bone morphogenetic protein-4, transforming growth factor- beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. Exp Cell Res 1994; 210:224-9.

Hentunen TA, Cunningham NS, Vuolteenaho O, Reddi AH, Vaananen HK. Osteoclast recruiting activity in bone matrix. Bone Miner 1994; 25:183-98.

Habal MB, Reddi AH. Bone grafts and bone induction substitutes. Clin Plast Surg 1994; 21:525-42.

Chang SC, Hoang B, Thomas JT, et al. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem 1994; 269:28227-34.

Ballock RT, Reddi AH. Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. J Cell Biol 1994; 126:1311-8.

Yu YM, Sklar MM, Nissley SP, Reddi AH. Changes in the expression of insulin-like growth factor II/mannose-6- phosphate receptor during endochondral bone development. Biochem Biophys Res Commun 1993; 195:516-24.

Schafer SJ, Luyten FP, Yanagishita M, Reddi AH. Proteoglycan metabolism is age related and modulated by isoforms of platelet-derived growth factor in bovine articular cartilage explant cultures. Arch Biochem Biophys 1993; 302:431-8.

Ripamonti U, Ma SS, Cunningham NS, Yeates L, Reddi AH. Reconstruction of the bone--bone marrow organ by osteogenin, a bone morphogenetic protein, and demineralized bone matrix in calvarial defects of adult primates. Plast Reconstr Surg 1993; 91:27-36.

Reddi AH, Cunningham NS. Initiation and promotion of bone differentiation by bone morphogenetic proteins. J Bone Miner Res 1993; 8 Suppl 2:S499-502.

Marden LJ, Quigley NC, Reddi AH, Hollinger JO. Temporal changes during bone regeneration in the calvarium induced by osteogenin. Calcif Tissue Int 1993; 53:262-8.

Marden LJ, Fan RS, Pierce GF, Reddi AH, Hollinger JO. Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects. J Clin Invest 1993; 92:2897-905.

Katz RW, Hollinger JO, Reddi AH. The functional equivalence of demineralized bone and tooth matrices in ectopic bone induction. J Biomed Mater Res 1993; 27:239-45.

Chen P, Yu YM, Reddi AH. Chondrogenesis in chick limb bud mesodermal cells: reciprocal modulation by activin and inhibin. Exp Cell Res 1993; 206:119-27.

Vukicevic S, Kleinman HK, Luyten FP, Roberts AB, Roche NS, Reddi AH. Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp Cell Res 1992; 202:1-8.

Ripamonti U, Reddi AH. Growth and morphogenetic factors in bone induction: role of osteogenin and related bone morphogenetic proteins in craniofacial and periodontal bone repair. Crit Rev Oral Biol Med 1992; 3:1-14.

Ripamonti U, Ma SS, Reddi AH. Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons. Plast Reconstr Surg 1992; 89:731-9; discussion 740.

Ripamonti U, Ma S, Reddi AH. The critical role of geometry of porous hydroxyapatite delivery system in induction of bone by osteogenin, a bone morphogenetic protein. Matrix 1992; 12:202-12.

Ripamonti U, Ma SS, van den Heever B, Reddi AH. Osteogenin, a bone morphogenetic protein, adsorbed on porous hydroxyapatite substrata, induces rapid bone differentiation in calvarial defects of adult primates. Plast Reconstr Surg 1992; 90:382-93.

Ripamonti U, Ma S, Cunningham NS, Yeates L, Reddi AH. Initiation of bone regeneration in adult baboons by osteogenin, a bone morphogenetic protein. Matrix 1992; 12:369-80.

Reddi AH. Regulation of cartilage and bone differentiation by bone morphogenetic proteins. Curr Opin Cell Biol 1992; 4:850-5.

Paralkar VM, Weeks BS, Yu YM, Kleinman HK, Reddi AH. Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen. J Cell Biol 1992; 119:1721-8.

Luyten FP, Cunningham NS, Vukicevic S, Paralkar V, Ripamonti U, Reddi AH. Advances in osteogenin and related bone morphogenetic proteins in bone induction and repair. Acta Orthop Belg 1992; 58:263-7.

Luyten FP, Yu YM, Yanagishita M, Vukicevic S, Hammonds RG, Reddi AH. Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures. J Biol Chem 1992; 267:3691-5.

Harrison ET, Jr., Luyten FP, Reddi AH. Transforming growth factor-beta: its effect on phenotype reexpression by dedifferentiated chondrocytes in the presence and absence of osteogenin. In Vitro Cell Dev Biol 1992; 28A:445-8.

DeSimone DP, Reddi AH. Vascularization and endochondral bone development: changes in plasminogen activator activity. J Orthop Res 1992; 10:320-4.

Cunningham NS, Paralkar V, Reddi AH. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Proc Natl Acad Sci U S A 1992; 89:11740-4.

Chen P, Carrington JL, Paralkar VM, Pierce GF, Reddi AH. Chick limb bud mesodermal cell chondrogenesis: inhibition by isoforms of platelet-derived growth factor and reversal by recombinant bone morphogenetic protein. Exp Cell Res 1992; 200:110-7.

Yu YM, Becvar R, Yamada Y, Reddi AH. Changes in the gene expression of collagens, fibronectin, integrin and proteoglycans during matrix-induced bone morphogenesis. Biochem Biophys Res Commun 1991; 177:427-32.

Williams-Ashman HG, Reddi AH. Differentiation of mesenchymal tissues during phallic morphogenesis with emphasis on the os penis: roles of androgens and other regulatory agents. J Steroid Biochem Mol Biol 1991; 39:873-81.

Ripamonti U, Magan A, Ma S, van den Heever B, Moehl T, Reddi AH. Xenogeneic osteogenin, a bone morphogenetic protein, and demineralized bone matrices, including human, induce bone differentiation in athymic rats and baboons. Matrix 1991; 11:404-11.

Reddi AH, Cunningham NS. Recent progress in bone induction by osteogenin and bone morphogenetic proteins: challenges for biomechanical and tissue engineering. J Biomech Eng 1991; 113:189-90.

Paralkar VM, Vukicevic S, Reddi AH. Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: implications for development. Dev Biol 1991; 143:303-8.

Paralkar VM, Hammonds RG, Reddi AH. Identification and characterization of cellular binding proteins (receptors) for recombinant human bone morphogenetic protein 2B, an initiator of bone differentiation cascade. Proc Natl Acad Sci U S A 1991; 88:3397-401.

Harrison ET, Jr., Luyten FP, Reddi AH. Osteogenin promotes reexpression of cartilage phenotype by dedifferentiated articular chondrocytes in serum-free medium. Exp Cell Res 1991; 192:340-5.

Hammonds RG, Jr., Schwall R, Dudley A, et al. Bone-inducing activity of mature BMP-2b produced from a hybrid BMP- 2a/2b precursor. Mol Endocrinol 1991; 5:149-55.

Chen P, Carrington JL, Hammonds RG, Reddi AH. Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor beta 1 and beta 2. Exp Cell Res 1991; 195:509-15.

Carrington JL, Chen P, Yanagishita M, Reddi AH. Osteogenin (bone morphogenetic protein-3) stimulates cartilage formation by chick limb bud cells in vitro. Dev Biol 1991; 146:406-15.

Carrington JL, Reddi AH. Parallels between development of embryonic and matrix-induced endochondral bone. Bioessays 1991; 13:403-8.

Bowers GM, Reddi AH. Regenerating the periodontium in advanced periodontal disease. J Am Dent Assoc 1991; 122:45-8.

Wientroub S, Weiss JF, Catravas GN, Reddi AH. Influence of whole body irradiation and local shielding on matrix- induced endochondral bone differentiation. Calcif Tissue Int 1990; 46:38-45.

Vukicevic S, Luyten FP, Reddi AH. Osteogenin inhibits proliferation and stimulates differentiation in mouse osteoblast-like cells (MC3T3-E1). Biochem Biophys Res Commun 1990; 166:750-6.

Vukicevic S, Paralkar VM, Cunningham NS, Gutkind JS, Reddi AH. Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development. Dev Biol 1990; 140:209-14.

Vukicevic S, Luyten FP, Kleinman HK, Reddi AH. Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: regulation by discrete domains of laminin. Cell 1990; 63:437-45.

Reddi AH, Cunningham NS. Bone induction by osteogenin and bone morphogenetic proteins. Biomaterials 1990; 11:33-4.

Paralkar VM, Nandedkar AK, Pointer RH, Kleinman HK, Reddi AH. Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. J Biol Chem 1990; 265:17281-4.

Mark DE, Hollinger JO, Hastings C, Jr., Chen G, Marden LJ, Reddi AH. Repair of calvarial nonunions by osteogenin, a bone-inductive protein [see comments]. Plast Reconstr Surg 1990; 86:623-30; discussion 631-2.

Marden LJ, Reddi AH, Hollinger JO. Growth and differentiation factors: role in bone induction and potential application in craniofacial surgery. J Craniofac Surg 1990; 1:154-60.

Katz RW, Felthousen GC, Reddi AH. Radiation-sterilized insoluble collagenous bone matrix is a functional carrier of osteogenin for bone induction. Calcif Tissue Int 1990; 47:183-5.

Doll BA, Towle HJ, Hollinger JO, Reddi AH, Mellonig JT. The osteogenic potential of two composite graft systems using osteogenin. J Periodontol 1990; 61:745-50.

Carrington JL, Reddi AH. Temporal changes in the response of chick limb bud mesodermal cells to transforming growth factor beta-type 1. Exp Cell Res 1990; 186:368-73.

Wlodarski KH, Reddi AH. Biochemical parameters of osteogenesis in epiphysis of mice irradiated and repopulated with syngeneic bone marrow. Folia Biol 1989; 35:197-206.

Vukicevic S, Luyten FP, Reddi AH. Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc Natl Acad Sci U S A 1989; 86:8793-7.

Reddi AH, Muthukumaran N, Ma S, et al. Initiation of bone development by osteogenin and promotion by growth factors. Connect Tissue Res 1989; 20:303-12.

Paralkar VM, Nandedkar AK, Reddi AH. Affinity of osteogenin, an extracellular bone matrix associated protein initiating bone differentiation, for concanavalin A. Biochem Biophys Res Commun 1989; 160:419-24.

Luyten FP, Cunningham NS, Ma S, et al. Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J Biol Chem 1989; 264:13377-80.

Landesman R, Reddi AH. In vivo analysis of the half-life of the osteoinductive potential of demineralized bone matrix using diffusion chambers. Calcif Tissue Int 1989; 45:348-53.

Kapur SP, Reddi AH. Influence of testosterone and dihydrotestosterone on bone-matrix induced endochondral bone formation. Calcif Tissue Int 1989; 44:108-13.

Hollinger J, Mark DE, Bach DE, Reddi AH, Seyfer AE. Calvarial bone regeneration using osteogenin [see comments]. J Oral Maxillofac Surg 1989; 47:1182-6; discussion 1187.

Wientroub S, Reddi AH. Influence of irradiation on the osteoinductive potential of demineralized bone matrix. Calcif Tissue Int 1988; 42:255-60.

Reddi AH, Ma SS, Cunningham NS. Induction and maintenance of new bone formation by growth and differentiation factors. Ann Chir Gynaecol 1988; 77:189-92.

96. Muthukumaran N, Ma S, Reddi AH. Dose-dependence of and threshold for optimal bone induction by collagenous bone matrix and osteogenin-enriched fraction. Coll Relat Res 1988; 8:433-41.

Luyten FP, Hascall VC, Nissley SP, Morales TI, Reddi AH. Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants. Arch Biochem Biophys 1988; 267:416-25.

Katz RW, Reddi AH. Dissociative extraction and partial purification of osteogenin, a bone inductive protein, from rat tooth matrix by heparin affinity chromatography. Biochem Biophys Res Commun 1988; 157:1253-7.

Howes R, Bowness JM, Grotendorst GR, Martin GR, Reddi AH. Platelet-derived growth factor enhances demineralized bone matrix- induced cartilage and bone formation. Calcif Tissue Int 1988; 42:34-8.

Carrington JL, Roberts AB, Flanders KC, Roche NS, Reddi AH. Accumulation, localization, and compartmentation of transforming growth factor beta during endochondral bone development. J Cell Biol 1988; 107:1969-75.

Wientroub S, Price PA, Reddi AH. The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and 24,25- dihydroxyvitamin D3 on bone gamma-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats. Calcif Tissue Int 1987; 40:166-72.

Wientroub S, Fisher LW, Reddi AH, Termine JD. Noncollagenous bone proteins in experimental rickets in the rat. Mol Cell Biochem 1987; 74:157-62.

Silbermann M, Tenenbaum H, Livne E, Leapman R, von der Mark K, Reddi AH. The in vitro behavior of fetal condylar cartilage in serum-free hormone- supplemented medium. Bone 1987; 8:117-26.

Silbermann M, Reddi AH, Hand AR, Leapman R, von der Mark K, Franzen A. Chondroid bone arises from mesenchymal stem cells in organ culture of mandibular condyles. J Craniofac Genet Dev Biol 1987; 7:59-79.

Silbermann M, Reddi AH, Hand AR, Leapman RD, Von der Mark K, Franzen A. Further characterisation of the extracellular matrix in the mandibular condyle in neonatal mice. J Anat 1987; 151:169-88.

Sampath TK, Muthukumaran N, Reddi AH. Isolation of osteogenin, an extracellular matrix-associated, bone- inductive protein, by heparin affinity chromatography. Proc Natl Acad Sci U S A 1987; 84:7109-13.

Robey PG, Young MF, Flanders KC, et al. Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. J Cell Biol 1987; 105:457-63.

Reddi AH, Wientroub S, Muthukumaran N. Biologic principles of bone induction. Orthop Clin North Am 1987; 18:207-12.

Wlodarski K, Marciniak M, Reddi AH. In vitro establishment of a murine Moloney sarcoma cell line. I. Its morphology and transplantation. Folia Biol 1986; 34:227-34.

Wlodarski KH, Reddi AH. Importance of skeletal muscle environment for ectopic bone induction in mice. Folia Biol 1986; 34:425-34.

Wlodarski KH, Reddi AH. Alkaline phosphatase as a marker of osteoinductive cells. Calcif Tissue Int 1986; 39:382-5.

Tian MY, Yanagishita M, Hascall VC, Reddi AH. Biosynthesis and fate of proteoglycans in cartilage and bone during development and mineralization. Arch Biochem Biophys 1986; 247:221-32.

Talwar HS, Reddi AH, Menczel J, Thomas WC, Jr., Meyer JL. Influence of aluminum on mineralization during matrix-induced bone development. Kidney Int 1986; 29:1038-42.

Landesman R, Reddi AH. Chemotaxis of muscle-derived mesenchymal cells to bone-inductive proteins of rat. Calcif Tissue Int 1986; 39:259-62.

Kapur SP, Reddi AH. Chondrogenic potential of mesenchymal cells elicited by bone matrix in vitro. Differentiation 1986; 32:252-9.

Wlodarski K, Ksiazkiewicz A, Marciniak M, Reddi AH. Does lymphopoiesis regulate tissue mast cells? Folia Biol 1985; 31:348-52.

Reddi AH. Age-dependent decline in extracellular matrix-induced local bone differentiation. Isr J Med Sci 1985; 21:312-3.

Reddi AH. Implant-stimulated interface reactions during collagenous bone matrix- induced bone formation. J Biomed Mater Res 1985; 19:233-9.

Muthukumaran N, Sampath TK, Reddi AH. Comparison of bone inductive proteins of rat and porcine bone matrix. Biochem Biophys Res Commun 1985; 131:37-41.

Muthukumaran N, Reddi AH. Bone matrix-induced local bone induction. Clin Orthop 1985:159-64.

Meyer JL, Reddi AH. Changes in pyrophosphatase activity during the de novo mineralization associated with cartilage and bone formation. Arch Biochem Biophys 1985; 242:532-9.

Landesman R, Reddi AH. Induction of endochondral bone by demineralized bone matrix from diabetic rats. Calcif Tissue Int 1985; 37:630-4.

Knospe WH, Husseini SG, Adler SS, Reddi AH. Decalcified tooth matrix powder induces new bone formation and hematopoietic microenvironment in the mouse. Int J Cell Cloning 1985; 3:320-9.

Yoon JW, Reddi AH. Decreased bone formation and mineralization in virus-induced diabetes mellitus. Am J Physiol 1984; 246:C177-9.

Sampath TK, Reddi AH. Distribution of bone inductive proteins in mineralized and demineralized extracellular matrix. Biochem Biophys Res Commun 1984; 119:949-54.

Sampath TK, Nathanson MA, Reddi AH. In vitro transformation of mesenchymal cells derived from embryonic muscle into cartilage in response to extracellular matrix components of bone. Proc Natl Acad Sci U S A 1984; 81:3419-23.

Sampath TK, Reddi AH. Importance of geometry of the extracellular matrix in endochondral bone differentiation. J Cell Biol 1984; 98:2192-7.

Sampath TK, Wientroub S, Reddi AH. Extracellular matrix proteins involved in bone induction are vitamin D dependent. Biochem Biophys Res Commun 1984; 124:829-35.

Peck WA, Reddi AH, Gordon SL. Local mechanisms that regulate bone formation: the subject of a recent NIH-sponsored workshop [editorial]. Calcif Tissue Int 1984; 36:1-3.

McCarthy KF, Wientroub S, Hale M, Reddi AH. Establishment of the hematopoietic microenvironment in the marrow of matrix-induced endochondral bone. Exp Hematol 1984; 12:131-8.

Gulati AK, Reddi AH, Zalewski AA. Changes in the extracellular matrix components fibronectin and laminin during immune rejection of skeletal muscle. Anat Rec 1984; 209:21-7.

Wientroub S, Wahl LM, Feuerstein N, Winter CC, Reddi AH. Changes in tissue concentration of prostaglandins during endochondral bone differentiation. Biochem Biophys Res Commun 1983; 117:746-50.

Somerman M, Hewitt AT, Varner HH, Schiffmann E, Termine J, Reddi AH. Identification of a bone matrix-derived chemotactic factor. Calcif Tissue Int 1983; 35:481-5.

Sampath TK, Reddi AH. Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix. Proc Natl Acad Sci U S A 1983; 80:6591-5.

Reddi AH. Extracellular bone matrix dependent local induction of cartilage and bone. J Rheumatol Suppl 1983; 11:67-9.

Knospe WH, Husseini SG, Adler SS, Reddi AH. Hematopoiesis on cellulose ester membranes (CEM). V. Enrichment of CEM by demineralized mouse bone matrix powder. Exp Hematol 1983; 11:1021-6.

Gulati AK, Zalewski AA, Reddi AH. An immunofluorescent study of the distribution of fibronectin and laminin during limb regeneration in the adult newt. Dev Biol 1983; 96:355-65.

Gulati AK, Reddi AH, Zalewski AA. Changes in the basement membrane zone components during skeletal muscle fiber degeneration and regeneration. J Cell Biol 1983; 97:957-62.

DeSimone DP, Reddi AH. Influence of vitamin A on matrix-induced endochondral bone formation. Calcif Tissue Int 1983; 35:732-9.

Burnett CC, Reddi AH. Influence of estrogen and progesterone on matrix-induced endochondral bone formation. Calcif Tissue Int 1983; 35:609-14.

Boskey AL, Reddi AH. Changes in lipids during matrix: induced endochondral bone formation. Calcif Tissue Int 1983; 35:549-54.

Wientroub S, Hagan MP, Reddi AH. Reduction of hematopoietic stem cells and adaptive increase in cell cycle rate in rickets. Am J Physiol 1982; 243:C303-6.

Somerman M, Schiffmann E, Reddi AH, Termine J. Regulation of the attachment and migration of bone cells in vitro. J Periodontal Res 1982; 17:527-9.

Sampath TK, DeSimone DP, Reddi AH. Extracellular bone matrix-derived growth factor. Exp Cell Res 1982; 142:460-4.

Reddi AH. Regulation of local differentiation of cartilage and bone by extracellular matrix: a cascade type mechanism. Prog Clin Biol Res 1982; 110:261-8.

Poole AR, Reddi AH, Rosenberg LC. Persistence of Cartilage proteoglycan and link protein during matrix- induced endochondral bone development: an immunofluorescent study. Dev Biol 1982; 89:532-9.

Gulati AK, Reddi AH, Zalewski AA. Distribution of fibronectin in normal and regenerating skeletal muscle. Anat Rec 1982; 204:175-83.

Weiss RE, Reddi AH, Nimni ME. Somatostatin can locally inhibit proliferation and differentiation of cartilage and bone precursor cells. Calcif Tissue Int 1981; 33:425-30.

Weiss RE, Reddi AH. Appearance of fibronectin during the differentiation of cartilage, bone, and bone marrow. J Cell Biol 1981; 88:630-6.

Weiss RE, Reddi AH. Role of fibronectin in collagenous matrix-induced mesenchymal cell proliferation and differentiation in vivo. Exp Cell Res 1981; 133:247-54.

Weiss RE, Reddi AH. Isolation and characterization of rat plasma fibronectin. Biochem J 1981; 197:529-34.

Sampath TK, Reddi AH. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci U S A 1981; 78:7599-603.

Reddi AH. Cell biology and biochemistry of endochondral bone development. Coll Relat Res 1981; 1:209-26.

Reddi AH, Kuettner KE. Vascular invasion of cartilage: correlation of morphology with lysozyme, glycosaminoglycans, protease, and protease-inhibitory activity during endochondral bone development. Dev Biol 1981; 82:217-23.

Rath NC, Reddi AH. Changes in polyamines, RNA synthesis, and cell proliferation during matrix-induced cartilage, bone, and bone marrow development. Dev Biol 1981; 82:211-6.

Rath NC, Hand AR, Reddi AH. Activity and distribution of lysosomal enzymes during collagenous matrix-induced cartilage, bone, and bone marrow development. Dev Biol 1981; 85:89-98.

Price PA, Lothringer JW, Baukol SA, Reddi AH. Developmental appearance of the vitamin K-dependent protein of bone during calcification. Analysis of mineralizing tissues in human, calf, and rat. J Biol Chem 1981; 256:3781-4.

Myllyla R, Tryggvason K, Kivirikko KI, Reddi AH. Changes in intracellular enzymes of collagen biosynthesis during matrix- induced cartilage and bone development. Biochim Biophys Acta 1981; 674:238-45.

Weiss RE, Reddi AH. Influence of experimental diabetes and insulin on matrix-induced cartilage and bone differentiation. Am J Physiol 1980; 238:E200-7.

Weiss RE, Reddi AH. Synthesis and localization of fibronectin during collagenous matrix- mesenchymal cell interaction and differentiation of cartilage and bone in vivo. Proc Natl Acad Sci U S A 1980; 77:2074-8.

Steinmann BU, Reddi AH. Changes in synthesis of types-I and -III collagen during matrix-induced endochondral bone differentiation in rat. Biochem J 1980; 186:919-24.

Reddi AH, Sullivan NE. Matrix-induced endochondral bone differentiation: influence of hypophysectomy, growth hormone, and thyroid-stimulating hormone. Endocrinology 1980; 107:1291-9.

Reddi AH, Meyer JL, Tew WP, Howard JE, Lehninger AL. Influence of phosphocitrate, a potent inhibitor of hydroxyapatite crystal growth, on mineralization of cartilage and bone. Biochem Biophys Res Commun 1980; 97:154-9.

Hauschka PV, Reddi AH. Correlation of the appearance of gamma-carboxyglutamic acid with the onset of mineralization in developing endochondral bone. Biochem Biophys Res Commun 1980; 92:1037-41.

Foidart JM, Reddi AH. Immunofluorescent localization of type IV collagen and laminin during endochondral bone differentiation and regulation by pituitary growth hormone. Dev Biol 1980; 75:130-6.

Smith RJ, Reddi AH, Phang JM. Changes in proline synthetic and degradative enzymes during matrix- induced cartilage and bone formation. Calcif Tissue Int 1979; 27:275-9.

Schwartz R, Reddi AH. Influence of magnesium depletion on matrix-induced endochondral bone formation. Calcif Tissue Int 1979; 29:15-20.

Reddi AH, Sullivan NE. Inhibition of mineralization by experimental lathyrism during matrix- induced endochondral bone differentiation. Proc Soc Exp Biol Med 1979; 162:445-8.

Rath NC, Reddi AH. Collagenous bone matrix is a local mitogen. Nature 1979; 278:855-7.

Rath NC, Reddi AH. Influence of adrenalectomy and dexamethasone on matrix-induced endochondral bone differentiation. Endocrinology 1979; 104:1698-704.

Rath NC, Reddi AH. Evaluation of anti-inflammatory drugs based upon the inhibition of matrix-induced ornithine decarboxylase activity during connective tissue proliferation. Proc Soc Exp Biol Med 1979; 162:320-3.

Faltz LL, Reddi AH, Hascall GK, Martin D, Pita JC, Hascall VC. Characteristics of proteoglycans extracted from the Swarm rat chondrosarcoma with associative solvents. J Biol Chem 1979; 254:1375-80.

Reddi AH, Hascall VC, Hascall GK. Changes in proteoglycan types during matrix-induced cartilage and bone development. J Biol Chem 1978; 253:2429-36.

Rath NC, Reddi AH. Changes in ornithine decarboxylase activity during matrix-induced cartilage, bone and bone marrow differentiation. Biochem Biophys Res Commun 1978; 81:106-13.

Reddi AH, Gay R, Gay S, Miller EJ. Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. Proc Natl Acad Sci U S A 1977; 74:5589-92.

Reddi AH, Anderson WA. Collagenous bone matrix-induced endochondral ossification hemopoiesis. J Cell Biol 1976; 69:557-72.

Reddi AH, Huggins CB. Hormone-dependent haematopoiesis in fibroblast-transformation ossicles. Nature 1976; 263:514-5.

Reddi AH, Huggins CB. Formation of bone marrow in fibroblast-transformation ossicles. Proc Natl Acad Sci U S A 1975; 72:2212-6.

Reddi AH. The matrix of rat calvarium as transformant of fibroblasts. Proc Soc Exp Biol Med 1975; 150:324-6.

Reddi AH, Huggins CB. Obligatory transformation of fibroblasts by bone matrix in rats fed sucrose ration. Proc Soc Exp Biol Med 1974; 145:475-8.

Reddi AH, Huggins CB. Cyclic electrochemical inactivation and restoration of competence of bone matrix to transform fibroblasts. Proc Natl Acad Sci U S A 1974; 71:1648-52.

Reddi AH. Bone matrix in the solid state: geometric influence on differentiation of fibroblasts. Adv Biol Med Phys 1974; 15:1-18.

Reddi AH, Huggins CB. Influence of geometry of transplanted tooth and bone on transformation of fibroblasts. Proc Soc Exp Biol Med 1973; 143:634-7.

Huggins CB, Reddi AH. Coagulation of blood plasma of guinea pig by the bone matrix. Proc Natl Acad Sci U S A 1973; 70:929-33.

Reddi AH, Huggins C. Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. Proc Natl Acad Sci U S A 1972; 69:1601-5.

Reddi AH, Huggins CB. Citrate and alkaline phosphatase during transformation of fibroblasts by the matrix and minerals of bone. Proc Soc Exp Biol Med 1972; 140:807-10.

Williams-Ashman HG, Reddi AH. Actions of vertebrate sex hormones. Annu Rev Physiol 1971; 33:31-82.

Reddi AH, Ewing LL, Williams-Ashman HG. Protein phospholinase reactions in mammalian testis. Stimulatory effects of adenosine 3':5'-cyclic monophosphate on the phosphorylation of basic proteins. Biochem J 1971; 122:333-45.

Reddi AH, Huggins C. Lactic-malic dehydrogenase quotients during transformation of fibroblasts into cartilage and bone. Proc Soc Exp Biol Med 1971; 137:127-9.

Huggins C, Wiseman S, Reddi AH. Transformation of fibroblasts by allogeneic and xenogeneic transplants of demineralized tooth and bone. J Exp Med 1970; 132:1250-8.

Reddi AH, Prasad MR. The reproductive cycle of the male Indian palm squirrel, Funambulus pennanti Wroughton. J Reprod Fertil 1968; 17:235-45.

Reddi AH, Prasad MR, Duraiswami S. Fructose and citric acid in the male accessory glands of the Indian palm squirrel, Funambulus pennanti (Wroughton). J Endocrinol 1966; 35:193-7.