mouse that roared
Cardiff is fond of beginning pathology lectures by projecting slides
of invasive breast cancer tumors on the screen behind the lectern
and asking listeners which is from the mouse and which is from the
human. He's done it hundreds of times and even pathologists in the
audience can't tell which is which.
all get it wrong," the UC Davis professor of pathology says
with a grin. "Every time."
the point. Mice and men have more in common than the title of a
Steinbeck novel. They share 80 percent of the same DNA. They both
get cancer. Genes that cause cancer in mice are very similar to
genes that cause cancer in humans. And with the advent of transgenic
mice - mice bred to express or not express specific genes -the rodent's
role as primary animal model for cancer studies has never been more
Cardiff's blend of expertise in human and mouse biology has never
been in greater demand.
mice are vital to cancer research for many reasons. They act as
sentinels for an array of molecular changes - cellular and genetic
anomalies that can develop into cancer. At the same time, they give
scientists a way to analyze the interaction of specific genes in
a living, breathing mammal. Knockout mice, for example, have genes
that have been artificially removed from the mouse genome, while
knock-in mice have genes artificially activated.
right: UC Davis pathologist Robert Cardiff
helps cancer investigators interpret
mutations in genetic mice.
Table of Contents |
To our Readers |
Building on Basics
Focusing on Patients |
In Translation |
Campus Connection |
News in Brief
UC Davis Health System |
© 2000, 2001, 2002 UC Regents. All rights reserved.