Nirmala Hariharan, Ph.D.
Assistant Adjunct Professor
Specialties
Regenerative Medicine
Infectious Diseases
Molecular Infectious Disease Diagnostics
Department
Locations and Contact
Additional Numbers
Physician Referrals
Research/Academic Interests
Dr. Hariharan's research interests broadly include: molecular mechanisms of heart disease with a focus on cardiac aging and regeneration, cell fate determination, understanding the role of nucleolar proteins in heart disease, and autophagy. She is also interested in studying molecular diagnostics for infectious diseases.
Division
Pharmacology
Undergraduate School
B.E. (Hons.), Birla Institute of Technology and Science, Pilani, Rajasthan, India 2005
Medical School
M.Sc. (Hons.), Birla Institute of Technology and Science, Pilani, Rajasthan, India 2005
Other School
Ph.D., Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School), Newark NJ 2011
Fellowship
Postdoctoral Fellow, Department of Biology, San Diego State University, San Diego CA 2011-2014
Western States Affiliate Postdoctoral Fellowship, American Heart Association, 2012, 2016
Academic Federation Innovative Development Award, UC Davis, 2015
Western States Affiliate Beginning Grant-In-Aid, American Heart Association, 2015
Finalist, Melvin L Marcus Young Investigator Award in Cardiovascular Sciences, American Heart Association, 2014
Finalist, Young Investigator Award, International Society for Heart Research - North American Section, 2014
Best of American Heart Association Specialty Conference-Basic Cardiovascular Sciences, 2012
Western States Affiliate Postdoctoral Fellowship, American Heart Association, 2012
Most Downloaded Original Research Article Award, Circulation Research, American Heart Association, 2011
Best Manuscript Award, Circulation Research, American Heart Association, 2011
To see a list of Dr. Hariharan's publications, please click here.
Ebeid DE, Khalafalla FG, Broughton KM, Monsanto MM, Esquer CY, Sacchi V, Hariharan N, Korski KI, Moshref M, Emathinger J, Cottage CT, Quijada PJ, Nguyen JH, Alvarez R, Völkers M, Konstandin MH, Wang BJ, Firouzi F, Navarrete JM, Gude NA, Goumans MJ, Sussman MA. Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling. Cardiovasc Res. 2021 Jan 1;117(1):201-211. doi:10.1093/cvr/cvaa066. PMID:32176281.
De La Mata A, Tajada S, O'Dwyer S, Matsumoto C, Dixon RE, Hariharan N, Moreno CM, Santana LF. BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes. Stem Cells. 2019 Jan;37(1):54-64. doi:10.1002/stem.2927. Epub 2018 Nov 22. PMID:30353632.
Matsumoto C, Jiang Y, Emathinger J, Quijada P, Nguyen N, De La Torre A, Moshref M, Nguyen J, Levinson AB, Shin M, Sussman MA, Hariharan N. Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate. Stem Cells. 2018 Jun;36(6):868-880. doi:10.1002/stem.2793. Epub 2018 Feb 25. PMID:29441645.
Sacchi V, Wang BJ, Kubli D, Martinez AS, Jin JK, Alvarez R Jr, Hariharan N, Glembotski C, Uchida T, Malter JS, Yang Y, Gross P, Zhang C, Houser S, Rota M, Sussman MA. Peptidyl-Prolyl Isomerase 1 Regulates Ca2+ Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na2+/Ca2+ Exchanger 1 Protein Levels and Function. J Am Heart Assoc. 2017 Oct 10;6(10):e006837. doi:10.1161/JAHA.117.006837. PMID:29018025.
Samse K, Hariharan N, Sussman MA. Personalizing cardiac regenerative therapy: At the heart of Pim1 kinase. Pharmacol Res. 2016 Jan;103:13-6. doi:10.1016/j.phrs.2015.11.001. Epub 2015 Nov 10. PMID:26563999.
Quijada P, Hariharan N, Cubillo JD, Bala KM, Emathinger JM, Wang BJ, Ormachea L, Bers DM, Sussman MA, Poizat C. Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment. J Biol Chem. 2015 Oct 16;290(42):25411-26. doi:10.1074/jbc.M115.657775. Epub 2015 Aug 31. PMID:26324717.
Quijada P, Salunga HT, Hariharan N, Cubillo JD, El-Sayed FG, Moshref M, Bala KM, Emathinger JM, De La Torre A, Ormachea L, Alvarez R Jr, Gude NA, Sussman MA. Cardiac Stem Cell Hybrids Enhance Myocardial Repair. Circ Res. 2015 Sep 25;117(8):695-706. doi:10.1161/CIRCRESAHA.115.306838. Epub 2015 Jul 30. PMID:26228030.
Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, Sacchi V, Truffa S, Joyo A, Voelkers M, Alvarez R, Sussman MA. Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells. Basic Res Cardiol. 2015 May;110(3):29. doi:10.1007/s00395-015-0488-3. Epub 2015 Apr 19. PMID:25893875.
Hariharan N, Sussman MA. Cardiac aging - Getting to the stem of the problem. J Mol Cell Cardiol. 2015 Jun;83:32-6. doi:10.1016/j.yjmcc.2015.04.008. Epub 2015 Apr 14. PMID:25886698.