Dr. Nguyen's research interests encompass several areas of basic and clinical and translational science. These include studies to understand outcome risk trajectories over time in patients on dialysis, such as cardiovascular events and infection-related hospitalization. He also collaborates on many studies to further elucidate the molecular and clinical features of fragile X premutation carriers and also in treatment studies for individuals with Fragile X Syndrome and fragile X premutation over the past decade. Motivated by these and other biomedical studies, Dr. Nguyen develops novel statistical methodologies in statistical bioinformatics (prediction, classification, false discovery rate, microarray data, dimensional reduction, partial least squares dimension reduction); case series method and measurement error; sparse longitudinal analysis (mixed effects model, varying-coefficient model) among others.
Public Health Sciences
Ph.D., UC Davis, Davis, California, 2000
M.S., UC Riverside, Riverside, CA, 1996
B.A., UC Irvine, Irvine, California, 1995
Member, American Association for the Advancement of Science
Member, American Statistical Association
Select Recent Publications
Berry-Kravis E, Hessl D, Rathmell B, Zarevics P, Cherubini M, Walton-Bowen K, Mu Y, Nguyen, DVGonzales-Heydrich I, Wang P, Carpenter R, Bear M, Hagerman RJ. Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, Phase 2 trial. Science Translational Medicine, 2012; 4, 152:127.
Mohammed SM, Senturk D, Dalrymple LS, Nguyen DV. Measurement error case series models with application to infection-cardiovascular risk in older patients on dialysis. Journal of the American Statistical Association, 2012;107, 1310-1323.
Dalrymple LS, Mohammed SM, Mu Y, Johansen KL, Chertow GM, Grimes B, Kaysen GA, Nguyen DV. The risk of cardiovascular-related events following infection-related hospitalizations in older patients on dialysis. Clinical Journal of the American Society of Nephrology, 2011;6, 1708-1713.
Senturk D, Nguyen DV. Varying coefficient models for sparse noise-contaminated longitudinal data. Statistica Sinica, 2011;21, 1831-1856.
Senturk D, Nguyen DV, Tassone F, Hagerman RJ, Carroll RJ, Hagerman PJ. Covariate adjusted correlation analysis with application to FMR1 premutation female carrier data. Biometrics, 2009;65, 781-792.
Verro P, Gorelick P, Nguyen DV. Aspirin plus dipyridamole versus aspirin for prevention of vascular events after stroke or TIA: A meta-analysis. Stroke, 2008; 39, 1358-1363.
Nguyen DV, Senturk D, Carroll RJ. Covariate-adjusted linear mixed effects models with an application to longitudinal data. Journal of Nonparametric Statistics, 2008;20, 459-481.
Chee K G, Nguyen DV, Brown M, Gandara DR, Wun T, Lara PN. Positron emission tomography and improved survival in lung cancer: The Will Rogers phenomenon revisited. Archives of Internal Medicine, 2008;168, 1541-1549.
Nguyen DV. Partial least squares dimension reduction for microarray gene expression data with a censored response. Mathematical Biosciences, 2005; 193, 119-137.
Davidson LA, Nguyen DV Hokanson RM, Callaway ES, Isett RB, Turner ND, Dougherty ER, Wang N, Lupton JR, Carroll RJ, Chapkin RS. Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Research, 2004; 64, 6797-6804.
Nguyen DV, Arpat AB, Wang N, Carroll RJ. DNA microarray experiments: biological and technological aspects. Biometrics, 2002;58, 701-717.
Nguyen DV, Rocke DM. Tumor classification by partial least squares using microarray gene expression data. Bioinformatics, 2002; 18, 39-50.