Aldrin Gomes, Ph.D.
Associate Professor
191 Briggs Hall
Davis Campus

We are interested in the molecular mechanisms of signal transduction, particularly in muscle contraction and cardiovascular disease. The two main research areas in my laboratory are: the role of the proteasome in normal, protected and diseased cardiac and skeletal muscle and the role of troponin in calcium regulation of muscle contraction in hypertrophic, dilated and restrictive cardiomyopathies.

For details about my research go to:

2016  Gilda JE, Lai X, Witzmann FA, Gomes AV. Delineation of molecular pathways involved in cardiomyopathies caused by troponin T mutations. Molecular and Cellular Proteomics. 15(6):1962-81.

2016  Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. Journal of Molecular and Cellular Cardiology. 94:131-144.

2016  Ghosh R, Goswami SK, Feitoza LF, Hammock B, Gomes AV. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 15;223:923-935.

2016  Nguyen S, Siu R, Dewey S, Cui Z, Gomes AV. Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. Front Physiol. 15;7:520.

2016  Carbonell T, Alva N, Sanchez-Nuño S, Dewey S, Gomes AV. Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. Oxid Med Cell Longev. 2016:9324692.

2016  Gilda JE, Xu Q, Martinez ME, Nguyen ST, Chase PB, Gomes AV. The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch. Biochem. Biophys. 1;601:88-96.

2016  Landry M, Gomes AV. Antibodies: Half of samples fail protein-blot tests. Nature. 529(7584):25

2016  West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes AV, Bodine SC, Baar K. Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 15;594(2):453-68.

2016  Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222.

2015  Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR; Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. AHA Council on Functional Genomics and Translational Biology, Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Hypertension, and Stroke Council. Circulation. 132(9):852-72.

2015  Gomes AV, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D. Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains. J Muscle Res Cell Motil. 36(6):447-61.

2015  Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes AV. Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLoS One. 2015 10(8):e0135392.

2015  Carbonell T, Gomes AV. Dynamic regulation of the proteasome by systolic overload. Journal of Molecular and Cellular Cardiology 87:1-3.

2015  Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. 81:162-75.

2015  Ghosh R, Alajbegovic A, Gomes AV. NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxid Med Cell Longev. 2015;2015:536962.

2015  Gilda JE, Gomes AV. Western blotting using in-gel protein labeling as a normalization control: stain-free technology. Methods Mol Biol. 1295: 381 -91.

2014  Jamart C, Gomes AV, Dewey S, Deldicque L, Raymackers JM, Francaux M. Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice. BMC Musculoskelet Disord. 15:166.

2014  Ghosh R, Gilda JE, Gomes AV. The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 11(5):549-60.

2014  Cui, Z., Scruggs, S.B., Gilda, J.E., Ping, P., Gomes, A.V. Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 71:32-42.

2014  Narashimhan M., Hong J., Atieno N., Muthusamy V.R., Davidson C.J., Abu-Rmaileh N., Richardson R., Gomes A.V., Hoidal J.R., Rajasekaran N.S. Nrf2 Deficiency Promotes Apoptosis and Impairs Pax7/MyoD Expression in Aging Skeletal Muscle Cells. Free Radical Biology and Medicine. 71:402-14.

2014  Wecksler A.T., Hwang S.H., Wettersten H.I., Gilda J.E., Patton A., Leon L.J., Carraway K.L. 3rd, Gomes A.V, Baar K., Weiss R.H., Hammock B.D. (2014) Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 25(4):433-46.

2014  Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. Influence of a constitutive increase in myofilament calcium-sensitivity on calcium-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 15;552-553

2014  Cui, Z., Hwang, S.M., and Gomes A.V. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 34(1):96-109.

2014  Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Human Molecular Genetics. 23(1):209-225 (cover picture article).

2014  Cui Z, Gilda JE, Gomes AV. Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 446: 44–52 (cover picture article).

2013  Dewey, S., Lai, X., Witzmann,F., Sohal, M., Gomes, A.V. Proteomic Analysis of Hearts from Akita Mice Suggests Increases in Soluble Epoxide Hydrolase and Antioxidative Programming are Key Changes in Early Stages of Diabetic Cardiomyopathy. Journal of Proteome Research, 12(9): 3920–3933.

2013  Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research, 100(1):63-73

2013  Gilda, J.E., Gomes, A.V. How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. Journal of Molecular Cellular Cardiology, 62(108): 108-110.

2013  Gilda, J.E., Gomes, A.V. Stain free total protein staining is a superior loading control to β-actin for Western blots. Analytical Biochemistry, 440(2): 186-188.

2013  Rajagopalan, V.,Zhao, M.,Reddy, S., Fajardo, G.,Wang, X., Dewey, S., Gomes, A,V., Bernstein, D. Altered Ubiquitin-Proteasome Signaling in Right Ventricular Hypertrophy and Failure. American Journal of Physiology, 305(4): H551-62.

2012  Iorga, A., Dewey, S., Partow-Navid1, R., Gomes AV, Mansoureh, E. Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice. PLOS One. 7(11): e48601.

2012  Xu, Q., Cui, Z., Venkatraman, G., Gomes, A.V. The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophysical Reviews 4, 125-135.

2012  Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen ,S., Miller, T., Parvatiyar, M.S,. Potter J.D. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 287:37362-70.

2012  Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 26:2986-99.

2011  Cui, Z., Dewey, S., Gomes, A.V. Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am. J. Cardiovasc. Dis. 1: 274-292.

2011  Hwee, D.T., Gomes, A.V., Bodine, S.C. Cardiac Proteasome Activity in Muscle Ring Finger-1 Null Mice at Rest and Following Synthetic Glucocorticoid Treatment. Am. J. Physiol. Endocrinol. Metab. 301:E967-77.

2010  Xu, Q., Dewey, S., Nguyen, S., Gomes, A.V. Malignant and benign mutations in familial cardiomyopathies: Insights into mutations linked to complex cardiovascular phenotypes. J. Mol. Cell. Cardiol. 48: 899-909.

2010  Dewey, S., Xu, Q., Gomes, A. Static and dynamic properties of the HCM myocardium. J Mol Cell Cardiol. 49:715-8

2010  Divald, A., Kivity, S., Wang, P., Hochhauser, E., Roberts, B., Teichberg, S., Gomes, A.V., Powell, S.R., Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circulation Research. 106: 1829-38.

2010  Dewey, S., Gomes, A.V. Non-Antigen Processing Diabetic Cardiac Immunoproteasomes. J. Mol. Cell. Cardiol. 49: 1-4.

2010  Tikunova, S.B., Liu, B., Swindle, N., Little, S.C., Gomes, A.V., Swartz, D.R., Davis, J.P. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 49:1975-84.

2009  Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 8,302-15.

2009  Mayr, M., Liem, D., Zhang, J., Li, X., Avliyakulov, N.K., Yang, J.I., Young, G., Vondriska, T.M., Ladroue, C., Madhu, B., Griffiths, J.R., Gomes, A., Xu, Q., Ping, P. Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J. Mol. Cell. Cardiol. 46,268-77.

2009  Mayr M., Grainger, D., Mayr, U., Leroyer, A.S., Leseche, G., Sidibe, A., Herbin, O., Yin, X., Gomes, A.V., Madhu, B., Griffiths, J.R., Xu, Q., Tedgui, A. and Boulanger, C.M. Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ. Cardiovasc. Genet. 2: 379 - 388.

2008  Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. Cardiac troponin T forms a tetramer in vitro. Biochemistry. 47, 1970-6.

2008  Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 283:20484-94.

2007  Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 6:2021-2031.

2006  Gomes, A.V., Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.

2006  Zong, C., Gomes, A.V., Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.

2005  Gomes, A.V., Liang, J., Potter J.D. Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 280, 30909-15.

2005  Gomes, A.V., Harada, K., Potter J.D. A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Calcium-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 39, 754-65.

2005  Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 280, 17584-92.

  • National Institute of Health
  • American Heart Association