Aldrin Gomes, Ph.D.
Associate Professor
191 Briggs Hall
Davis Campus

We are interested in the molecular mechanisms of signal transduction, particularly in muscle contraction and cardiovascular disease. The two main research areas in my laboratory are: the role of the proteasome in normal, protected and diseased cardiac and skeletal muscle and the role of troponin in calcium regulation of muscle contraction in hypertrophic, dilated and restrictive cardiomyopathies.

For details about my research go to:

Gilda JE, Lai X, Witzmann FA, Gomes AV. Delineation of molecular pathways involved in cardiomyopathies caused by troponin T mutations. Molecular and Cellular Proteomics. 2016 Jun;15(6):1962-81.

Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. Journal of Molecular and Cellular Cardiology. 2016 May;94:131-144.

Ghosh R, Goswami SK, Feitoza LF, Hammock B, Gomes AV. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 2016 Nov 15;15;223:923-935.

Nguyen S, Siu R, Dewey S, Cui Z, Gomes AV. Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. Front Physiol. 2016 Nov 15;7:520.

Carbonell T, Alva N, Sanchez-Nuño S, Dewey S, Gomes AV. Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. Oxid Med Cell Longev. 2016;2016:9324692.

Gilda JE, Xu Q, Martinez ME, Nguyen ST, Chase PB, Gomes AV. The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch. Biochem. Biophys. 2016 Jul 1;601:88-96.

Landry M, Gomes AV. Antibodies: Half of samples fail protein-blot tests. Nature. 2016 Jan 7;529(7584):25

West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes AV, Bodine SC, Baar K. Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 2016 Jan 15;594(2):453-68.

Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.

Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR; Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. AHA Council on Functional Genomics and Translational Biology, Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Hypertension, and Stroke Council. Circulation. 2015 Sep 1;132(9):852-72.

Gomes AV, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D. Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains. J Muscle Res Cell Motil. 2015 Dec;36(6):447-61.

Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes AV. Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLoS One. 2015 Aug 19;10(8):e0135392.

Carbonell T, Gomes AV. Dynamic regulation of the proteasome by systolic overload. Journal of Molecular and Cellular Cardiology 2015 Oct;87:1-3.

Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr;81:162-75.

Ghosh R, Alajbegovic A, Gomes AV. NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxid Med Cell Longev. 2015;2015:536962.

Gilda JE, Gomes AV. Western blotting using in-gel protein labeling as a normalization control: stain-free technology. Methods Mol Biol. 2015;1295: 381 -91.

Jamart C, Gomes AV, Dewey S, Deldicque L, Raymackers JM, Francaux M. Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice. BMC Musculoskelet Disord. 2014 May 22;15:166.

Ghosh R, Gilda JE, Gomes AV. The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 2014 Oct;11(5):549-60.

Cui, Z., Scruggs, S.B., Gilda, J.E., Ping, P., Gomes, A.V. Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 2014 Jun;71:32-42.

Narashimhan M., Hong J., Atieno N., Muthusamy V.R., Davidson C.J., Abu-Rmaileh N., Richardson R., Gomes A.V., Hoidal J.R., Rajasekaran N.S. Nrf2 Deficiency Promotes Apoptosis and Impairs Pax7/MyoD Expression in Aging Skeletal Muscle Cells. Free Radical Biology and Medicine. 2014 Jun;71:402-14.

Wecksler A.T., Hwang S.H., Wettersten H.I., Gilda J.E., Patton A., Leon L.J., Carraway K.L. 3rd, Gomes A.V, Baar K., Weiss R.H., Hammock B.D. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr;25(4):433-46.

Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. Influence of a constitutive increase in myofilament calcium-sensitivity on calcium-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 2014 Jun 15;552-553

Cui, Z., Hwang, S.M., and Gomes A.V. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014 Jan;34(1):96-109.

Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Human Molecular Genetics. 2014 Jan 1;23(1):209-225 (cover picture article).

Cui Z, Gilda JE, Gomes AV. Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 2014 Feb 1;446: 44–52 (cover picture article).

Dewey, S., Lai, X., Witzmann,F., Sohal, M., Gomes, A.V. Proteomic Analysis of Hearts from Akita Mice Suggests Increases in Soluble Epoxide Hydrolase and Antioxidative Programming are Key Changes in Early Stages of Diabetic Cardiomyopathy. Journal of Proteome Research, 2013 Sep 6;12(9): 3920–3933.

Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research, 2013 Oct 1;100(1):63-73

Gilda, J.E., Gomes, A.V. How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. Journal of Molecular Cellular Cardiology, 2013 Sep;62(108): 108-110.

Gilda, J.E., Gomes, A.V. Stain free total protein staining is a superior loading control to β-actin for Western blots. Analytical Biochemistry, 2013 Sep 15;440(2): 186-188.

Rajagopalan, V.,Zhao, M.,Reddy, S., Fajardo, G.,Wang, X., Dewey, S., Gomes, A,V., Bernstein, D. Altered Ubiquitin-Proteasome Signaling in Right Ventricular Hypertrophy and Failure. American Journal of Physiology, 2013 Aug 15;305(4): H551-62.

Iorga, A., Dewey, S., Partow-Navid1, R., Gomes AV, Mansoureh, E. Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice. PLOS One. 2012;7(11): e48601.

Xu, Q., Cui, Z., Venkatraman, G., Gomes, A.V. The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophysical Reviews 4, 2012 June;125-135.

Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen ,S., Miller, T., Parvatiyar, M.S,. Potter J.D. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 2012 Oct 26;287:37362-70.

Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 2012 Jul;26:2986-99.

Cui, Z., Dewey, S., Gomes, A.V. Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am. J. Cardiovasc. Dis. 2011;1: 274-292.

Hwee, D.T., Gomes, A.V., Bodine, S.C. Cardiac Proteasome Activity in Muscle Ring Finger-1 Null Mice at Rest and Following Synthetic Glucocorticoid Treatment. Am. J. Physiol. Endocrinol. Metab. 2011 Nov;301:E967-77.

Xu, Q., Dewey, S., Nguyen, S., Gomes, A.V. Malignant and benign mutations in familial cardiomyopathies: Insights into mutations linked to complex cardiovascular phenotypes. J. Mol. Cell. Cardiol. 2010 May;48: 899-909.

Dewey, S., Xu, Q., Gomes, A. Static and dynamic properties of the HCM myocardium. J Mol Cell Cardiol. 2010 Nov;49:715-8

Divald, A., Kivity, S., Wang, P., Hochhauser, E., Roberts, B., Teichberg, S., Gomes, A.V., Powell, S.R., Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circulation Research. 2010 Jun 25;106: 1829-38.

Dewey, S., Gomes, A.V. Non-Antigen Processing Diabetic Cardiac Immunoproteasomes. J. Mol. Cell. Cardiol. 2010 Jul;49: 1-4.

Tikunova, S.B., Liu, B., Swindle, N., Little, S.C., Gomes, A.V., Swartz, D.R., Davis, J.P. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 2010 Mar 9;49:1975-84.

Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 2009 Feb;8,302-15.

Mayr, M., Liem, D., Zhang, J., Li, X., Avliyakulov, N.K., Yang, J.I., Young, G., Vondriska, T.M., Ladroue, C., Madhu, B., Griffiths, J.R., Gomes, A., Xu, Q., Ping, P. Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J. Mol. Cell. Cardiol. 2009 Feb;46,268-77.

Mayr M., Grainger, D., Mayr, U., Leroyer, A.S., Leseche, G., Sidibe, A., Herbin, O., Yin, X., Gomes, A.V., Madhu, B., Griffiths, J.R., Xu, Q., Tedgui, A. and Boulanger, C.M. Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ. Cardiovasc. Genet. 2009 Aug;2: 379 - 388.

Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. Cardiac troponin T forms a tetramer in vitro. Biochemistry. 2008 Feb 19;47, 1970-6.

Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 2008 Jul 18;283:20484-94.

Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 2007 Nov;6:2021-2031.

Gomes, A.V., Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 2006 Aug 18;99:362-71.

Zong, C., Gomes, A.V., Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 2006 Aug 18;99:372-80.

Gomes, A.V., Liang, J., Potter J.D. Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 2005 Sep 2;280, 30909-15.

Gomes, A.V., Harada, K., Potter J.D. A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Calcium-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 2005 Jul 06;39, 754-65.

Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 2005 May 6;280, 17584-92.

  • National Institute of Health
  • American Heart Association