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Department of Physiology and Membrane Biology

Department of Physiology and Membrane Biology

Peter Cala, Ph.D.

Peter Cala, Ph.D.

Professor Emeritus
4153 Tupper Hall
Davis Campus
(530) 752-1285

Recent/Current Society Affiliations

American Physiological Society

Society of General Physiologists

Association of Chairs of Physiology Departments

Mount Desert Island Biological Laboratory

Graduate Group Affiliations

Molecular, Cellular and Integrative Physiology

Biochemistry, Molecular, Cellular and Developmental Biology

Research Interests

Electroneutral Ion Transport: Na/H and K/H Exchange
NHE1 Structure Function Relationships
Hypoxic and Ischemic Cytotoxicity
Cell Volume and pH Regulation
Membranes and Transport
Red blood cells
Tumor Growth and Proliferation


Representative Publications

2011  Nygaard, EB, Lagerstedt, JO, Bjerre, G, Shi, B, Budamagunta, M, Poulsen, KA, Meinild, S, Rigor, RR, Voss, JC, Cala, PM, Pedersen, SF. Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1. J Biol Chem 286: 634-48. PMCID 3013023

2010  Ortiz-Acevedo A, Rigor III R. R, Maldonado H. M, Cala P.M. Coordinated control of volume regulatory Na+/H+ and K+/H+ exchange pathways in Amphiuma red blood cells. Am J Physiol Cell Physiol Mar;298(3):C510-20.

2008  Ortiz-Acevedo A, Rigor III RR, Maldonado HM, Cala PM. Activation of 2 Na +/H+ and K+/H+ Exchange by Calyculin A in Amphiuma tridactylum Red Blood Cells; implications for the control of volume-induced ion flux activity. Am J Physiol Cell Physiol, 284: C-1123-32.

2007  King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 282(27): 19716-27. Epub 2007 May 10.

2005  Anderson, S.E., D. M. Kirkland, A. Beyschau, and P.M. Cala. Acute effects of 17ß-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am J. Physiol: Cell Physiol. 288: C57-C64.

2003  Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am J Physiol Cell Physiol 284: C1561-C1576.

2000  McLean LA, J. Roscoe, N. K. Jorgensen, F. A. Gorin, and P. M. Cala. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. American Journal of Physiology 278: (Cell Physiol. 47) C676-C688.

1999  McLean, LA, S. Zia, F. A. Gorin, and P. M. Cala. Cloning and expression of the Na+exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. American Journal of Physiology 276 (Cell Physiol. 45): C1025-C1037.

1990  Anderson, S.E., E. Murphy, C. Steenbergen, R.E. London, and P.M. Cala. Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. American Journal of Physiology 259 (Cell Physiol. 28):C940-C948.

1983  Cala, Peter M. Volume regulation by Amphiuma red blood cells: The role of Ca+2 as a modulator of the alkali metal/proton exchanger. Journal of General Physiology 82:761-784.

1983  Cala, Peter M. Volume regulation by red blood cells: Mechanisms of ion transport. Molecular Physiology 4:33-52.

1980  Cala, Peter M. Volume regulation by Amphiuma red blood cells: The membrane potential and its implications regarding the nature of the ion flux pathways. Journal of General Physiology 76:683-708.

1977  Cala, Peter M. Volume regulation by flounder red blood cells in anisotonic media. Journal of General Physiology 69:537-552.


Recent/Current Teaching

HPH100, Special Study-Physiology
MCP210, Advanced Physiology
HPH400, Human Physiology
SUR493C/HPH493, Care of the Critically Ill Surgical Patient


Honors and Awards

  • National Institute of Health Merit Award
  • President, Association of Chairs of Physiology Departments
  • Past President, Association of Chairs of Physiology Departments