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Department of Physiology and Membrane Biology

Department of Physiology and Membrane Biology

Sue Bodine, Ph.D.

Sue Bodine, Ph.D.

Professor
189 Briggs
Davis Campus
(530) 752-0694
e-mail

Research Interests

Dr. Bodine is a Neuromuscular Physiologist whose general field of study is Skeletal Muscle Plasticity. Her primary research interests are in understanding the cellular and molecular mechanisms that regulate skeletal muscle size under growth and atrophy conditions. Currently her lab is studying the role of mTOR-mediated pathways in the regulation of muscle growth and adaptive hypertrophy in young and aging animals. In addition, her lab is investigating the physiological function and transcriptional regulation of two muscle specific E3 Ubiquitin Ligases: MuRF1 and MAFbx, in both skeletal and cardiac tissues.

 

Representative Publications

2013   Hwee, DT, Baehr, LM, Philp, A., Baar, K and Bodine, SC. Maintenance of Muscle Mass and Load-Induced Growth in Muscle Ring Finger 1 Null Mice with Aging. Aging Cell 2013 (accepted August 9, 2013).

2013   Bodine, S.C. Disuse-Induced Muscle Wasting. Invited Review: International J. Biochem Cell Biol. 45: 2200-2208, 2013.

2012   Gomes, A.V. Waddell, D.S., Siu, R., Stein, M., Dewey, S., Furlow, J.D., and Bodine, S.C. Upregulation of Proteasome Activity in Muscle Ring Finger-1 Null Mice Following Denervation. FASEB J Jul; 26(7) 2986-2999, 2012 (Epub 2012 April 16).

2012   Bodine, S.C. and Baar, K. Analysis of Muscle Hypertrophy in Models of Skeletal Muscle Overload. Methods Molecular Biology 798: 213-229, 2012.

2011  Baehr, L.M., Furlow, J.D., and Bodine, S.C. Muscle Sparing in Muscle Ring Finger-1 Null Mice: Response to Synthetic Glucocorticoid. Journal of Physiology (Lond). 589: 4759-4776, 2011.

2011  Hwee, DT, Gomes AV and Bodine SC. Cardiac proteasome activity in Muscle Ring Finger 1 null mice at rest and following synthetic glucocorticoid treatment. Am J Physiol Endo Metabo. 2011 Aug 9 (Epub ahead of print)

2011  Baehr, LM, Furlow, JD and Bodine SC. Muscle sparing in Muscle Ring Finger 1 null mice: Response to synthetic glucocorticoids. J. Physiol. 2011 Aug 1. (epub ahead of print).

2009  Sitnick, M., Bodine, S.C. and Rutledge, J.C. Chronic high fat feeding attenuates load-induced hypertrophy in mice. J. Physiology London 587: 5753-5765, 2009.

2009  Hwee, D.T. and Bodine, S.C. Age-related deficit in load-induced skeletal muscle growth. J. Geron. Biol. Sci. 64: 618-628, 2009.

2008  Waddel, D.S., Baehr, L.M., van den Brandt, J., Johsen, S.A., Reichardt, H.M., Furlow, J.D., and Bodine, S.C. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy associated MuRF1 gene. Am. J. Physiol Endo Metabo 295: E785-E797, 2008. Epub 2008 July 8.

2007  Spangenburg EE, Le Roth, D., Ward, CW., and Bodine SC. A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J. Physiol. 586: 283-291, 2008. Epub 2007 Nov.1.

2007  Cohen, T.J., Wadell, D.S., Barrientos, T., Lu, Z., Feng, G., Cox, G., Bodine S.C., Yao, T-P. The histone deacetylase DHAC4 connects neural activity to muscle transcriptional reprogramming. J. Biol. Chem. 282: 33752-9, 2007. Epub 2007 Sept 16.

 

Recent/Current Teaching

EXB 101 Exercise Physiology
EXB 110 Exercise Metabolism
MCB 210A Cellular Physiology

 

Honors and Awards

  • Chair, NIH Grant Review Panel: Skeletal Muscle and Exercise Physiology (July 1, 2013- June 30, 2015)
  • Councilor, Environmental and Exercise Physiology Section, American Physiological Society (May 1, 2013- April 31,2016)
  • Associate Editor, American Journal of Physiology, Endocrinology and Metabolism
  • Associate Editor, Journal of Applied Physiology
  • Reviewing Editor, Frontiers in Skeletal Muscle Physiology
  • Regular Member, Veteran's Administration Merit Grant Review Study Section: Neurodegenerative Diseases and Aging
  • Regular Member, NIH Grant Review Panel: Skeletal Muscle and Exercise Physiology