Mingyi Chen, M.D., Ph.D.

Associate Professor

Department of Pathology and Laboratory Medicine
UC Davis Health System
PATH Building
4400 V Street
Sacramento, CA 95817

Ph: (916) 734-3587
Pager: (916) 816-0202

Clinical Interests

  • Hematopathology- lymphoma, leukemia, flow cytometry, bone marrow  transplant and diagnostic molecular pathology
  • Pulmonary pathology, and GI-liver pathology


Research Interests

  • Sickle cell disease, thrombosis, and vascular biology
  • Molecular pathogenesis of lymphoma and leukemia, tumor immunology and GVHD
  • Viral infections and cancergenesis, and cancer stem cells


Brief Biography

  • Medical School: Peking University Health Science Center, China
  • Graduate School: Ph.D. in Pharmacology, Kyoto University, Japan
  • Postdoctoral Fellowship: Howard Hughes Medical Institute/UCLA
  • Internship: University of California, San Diego
  • Residency: Loma Linda University Medical Center
  • Fellowship: Hematopathology, City of Hope National Medical Center

Board Certification

  • Diplomate of the American Board of Pathology (Anatomic and clinical pathology) (08/2009)
  • Diplomate of the American Board of Pathology in Hematology (10/2010)


Recent Publications (after 2005)

  1. Zhang J, Xu E, Ren C, Yan W, Zhang M, Chen M, Cardiff  RD , Imai DM , Wisner E, and Chen X. Mice Deficient in RBM38, a Target of the p53 Family, are Susceptible to Accelerated Aging and Spontaneous Tumors. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18637-42.

  2. Pai CC, Chen M, Mirsoian A, Grossenbacher SK, Tellez J, Ames E, Sun K, Blazar BR, Murphy WJ, Mehrdad A. Treatment of Chronic Graft versus Host Disease with Bortezomib. Blood. 2014 Sep 4;124(10):1677-88. (Commentary: Proteasome: target for acute and chronic GVHD? Blood 2014; 124:1551-1552).

  3. Tellez, J, Jaing C, Wang J, Green R, and Chen M. Detection of Epstein-Barr virus (EBV) in human lymphoma tissue by a novel microbial detection array. Biomark Res. 2014 Dec 5;2(1):24..

  4. Durham BH and Chen M. Overview of Pathogenesis of Autologous Graft-Versus-Host Disease. Clinical Microbiology and Pathology. 2014, 2014, 1(2): 011.

  5. Mirsoian A, Boucklaka MN, Sckisel GD, Chen M, Pai CS, Maverakis,E, Spencer RG. Fishbein KF, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Longo DL, Blazar BR, Taub DD, and Murphy WJ. Adiposity as a Principal Component of Lethal Cytokine Storm Following Immunotherapy in Aged Mice. J Exp Med. 2014 Nov 17;211(12):2373-83.

  6. Canter RJ, Ames E, Mac S, Grossenbacher SK, Chen M, Li CS, Borys D, Smith RC, Tellez J, Sayers TJ, Monjazeb AM, Murphy WJ. Anti-Proliferative but not Anti-Angiogenic Tyrosine Kinase Inhibitors Enrich for Cancer Stem Cells in Soft Tissue Sarcoma. BMC Cancer 2014 Oct 10;14(1):756.

  7. Alvarez M, Bouchlaka MN, Sckisel GD, Sungur CM, Chen M, Murphy WJ. J Immunol. 2014 Jul 7. pii: 1400034. Increased Antitumor Effects Using IL-2 with Anti-TGF-? Reveals Competition between Mouse NK and CD8 T Cells. J Immunol. 2014 Aug 15;193(4):1709-16.

  8. Pai CC, Hsiao HH, Sun K, Chen M, Hagino T, Tellez J, Mall C, Blazar BR, Monjazeb A, Abedi M, Murphy WJ. Therapeutic benefit of bortezomib on acute GVHD is tissue specific and is associated with IL-6 levels. Biol Blood Marrow Transplant. 2014 Jul 23. pii: S1083-8791(14)00448-50.

  9. Zhang H, Li Y, Lin TY, Xiao K, Haddad AS, Henderson PT, Jonas BA, Chen M, Xiao W, Liu R, Lam KS, Pan CX. Nanomicelle Formulation Modifies the Pharmacokinetic Profiles and Cardiac toxicity of Daunorubicin. Nanomedicine (Lond). 2014 Aug;9(12):1807-20.

  10. Bouchlaka M Sckisel G, Chen M, Mirsoan A, Zamora A, Monjazeb A, Longo D, Blazar BR, Taub DD,  Murphy WJ. Aging predisposes to acute inflammatory induced pathology following tumor immunotherapy. J Exp Med. 2013 Oct 21;210(11):2223-37 (Commentary: Cancer immunotherapy for the elderly. Nat Rev Immunol. 2013 Nov;13(11):774).

  11. Chen M, Abedi M. Atypical lymphocytosis and cold agglutinin hemolytic anemia associated with monoclonal gammopathy in HIV-infected patient with marrow involvement by diffuse large B-cell lymphoma. Blood, 2013 Nov 28;122(23):3711

  12. Chen M, Krishnamurthy A, Mohamed AR, Green R. Hematological disorders following gastric bypass surgery: emerging concepts of the interplay between nutritional deficiency and inflammation. Biomed Res Int. 2013;2013:205467.

  13. Chen M, Green R. Circulating plasma cells with Russell bodies in osteroslerotic myeloma. Blood 2013 July 11; 122:160.

  14. Chen M, Olson K. Colonic graft-versus-host disease (GVHD) manifesting as eosinophilic colitis following autologous hematopoietic stem cell transplantation. Blood. 2013 May 16;121(20):4020.

  15. Sungur CM, Tang-Feldman YJ, Ames E, Alvarez M, Chen M, Longo DL, Pomeroy C, Murphy WJ. Murine natural killer cell licensing and regulation by T regulatory cells in viral responses. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7401-6.

  16. Chen M, Van Ness M, Guo Y, Gregg J. Molecular pathology of pancreatic neuroendocrine tumors. J Gastrointest Oncol. 2012 Sep;3(3):182-8.

  17. Van Ness M, Gregg J, Wang J, Chen M. Genetics and molecular pathology of gastric malignancy: Development of targeted therapies in the era of personalized medicine. J Gastrointest Oncol. 2012 Sep;3(3):243-51.

  18. Sun K, Hsiao HH, Li M, Ames E, Bouchlaka M, Welniak LA, Hagino T, Jagdeo J, Pai CC, Chen M, Blazar BR, Abedi M, Murphy WJ. INF-gamma receptor-deficient donor t cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation. J Immunol. 2012 Aug 15;189(4):2033-42.

  19. Bautista-Quach MA, Ake CD, Chen M, Wang J.Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. J Gastrointest Oncol. 2012 Sep;3(3):209-25.

  20. Afify A, Das S, Chen M. Two Smalls in One: co-incident small cell carcinoma and small lymphocytic lymphoma in a lymph node diagnosed by fine-needle aspiration biopsy. CytoJournal 2012, 9(5):1-5.

  21. Sonu R, Song J, Chen M. Extramedullary hematopoiesis associated with myeloproliferative neoplasm manifesting as pleural effusion: Case report and review of literature. J Hematopathol (24 May 2012), pp. 1-7.

  22. Yang Y, Batth SS, Chen M, Borys D, Phan H. Enteropathy-associated T cell lymphoma presenting with acute abdominal syndrome: a case report and review of literature. J Gastrointest Surg. 2012 Jul;16(7):1446-9.

  23. Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, Redelman D, Murphy WJ. Mouse NK Cell-Mediated Rejection of Bone Marrow Allografts Exhibits Patterns Consistent with Ly49 Subset Licensing. Blood. 2012 Feb 9;119(6):1590-8.

  24. Sonu R, Gregg J, and Chen M. Splenic Marginal Zone Lymphoma with isolated t(8;14)(q24.1;q32) /MYC Rearrangement. J Hematopathol (2012) 5 (3) 141-147.

  25. Chen M, Argawal R., Nasseri-Nik N, Sloman A, Weiss LM. Indeterminate cell tumor of spleen. Human Pathology 2012 Feb;43(2):307-11.

  26. Chen M, Kim Y, Huang Q, Chang K, Gaal K, Weiss LM. Acute myeloid leukemia with an unusual histologic pattern mimicking metastatic neoplasm in bone marrow: a diagnostic pitfall. J Hematopathol (2011) 4 (2):117-122.

  27. Chen M, Wang J. Gaucher disease: review of the literature. Arch Pathol Lab Med. 2008 May;132(5):851-3.

  28. Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest. 2007 Aug;117(8):2337-46.

  29. Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors. FEBS Lett. 2006 Sep 4;580(20):4835-41.

  30. Chen M, Beaven S, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. J Lipid Res. 2005 Dec;46(12):2570-9.

  31. Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab. 2005 Mar;1(3):201-13.

  32. Chen M, Sawamura T. Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). J Mol Cell Cardiol. 2005 Sep;39(3):553-61.

  33. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005 Aug 12;280(32):29256-62.