Actively enrolling and upcoming studies (Updated August 2017)

Sponsor Title Areas of Study
Eligibility

PI/Co-PI
Sub-Investigators

Ethicon A Single-Blinded, Randomized, Controlled Study to Evaluate the Safety and Effectiveness of EVICEL® Fibrin Sealant (Human) Compared to a Hydrogel Sealant as an Adjunct to Sutured Dural Repair
(ClinicalTrials.gov identifier: NCT02457546)
Cranial Surgery - New Dural Sealant

Patients at least 18 years of age undergoing craniotomy or craniectomy surgery

Boggan

NIH Grant Fluorescence Lifetime Technique for Detection of Radiation Necrosis vs. Cancer Recurrence
(ClinicalTrials.gov identifier: NCT01981148)
Brain Cancer - New Technology

Diagnosis of metastatic cancer or any grade of glioma in which the diagnosis of possible tumor progression, recurrence or radiation necrosis has been made.

Boggan

InVivo The INSPIRE Study: InVivo Study of Probable Benefit of the Neuro-
Spinal ScaffoldTM for Safety and Neurologic Recovery in Subjects with Complete Thoracic AIS A Spinal Cord Injury
(ClinicalTrials.gov identifier: NCT02138110)
Acute Spinal Cord Injury (Thoracic)-New Surgical Treatment at Time of Initial Surgery

Patients age 16 – 70 years who are newly diagnosed with a T2- T12/L1 (neurological level) functionally complete spinal cord injury (AIS A) and are scheduled for spinal stabilization surgery within 96 hours after the initial injury.

Kim

Vertex A Phase 2b/3, Double-blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
(ClinicalTrials.gov identifier: NCT0266984)
Acute Spinal Cord Injury (Cervical) - Investigational Drug at time of Initial Surgery

Patients 14 - 75 years of age who are newly diagnosed with acute traumatic cervical spinal cord injury and are scheduled for spinal stabilization surgery within 72 hour after the initial injury.

Kim

Mesoblast A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of rexlemestrocel-L Alone or Combined with Hyaluronic Acid (HA) in Subjects with Chronic Discogenic Lumbar Back Pain Through 12 Months
(ClinicalTrials.gov identifier: NCT0241273)
Spine-Stem Cell Therapy for Degenerative Disc Disease (Lumbar)

Patients at least 18 years of age with chronic low back pain (> 6 months duration) not adequately controlled by conservative measures and associated with moderate radiographic degenerative changes of a disc.

Kim

Orthofix Safety and Efficacy of Pulsed Electromagnetic Fields (Cervical-Stim®) as an Adjunct to Enhance Union in Conservatively Treated Type II Fractures of the Odontoid Process
(ClinicalTrials.gov identifier: NCT02281994)
Spine Trauma - Bone Stimulator

Patients 50 years or older who have sustained a fracture of the odontoid process and who are not surgical candidates.

Kim

Investigator Initiated The Effect of Focused Attention and Compassion Meditation on Intracranial Epileptiform Activity and Local Field Potentials in Epilepsy Patients Epilepsy

Patients age 18-65 years with intractable epilepsy being monitored by scalp EEG and/or depth electrodes

Girgis

Investigator

Initiated

The Role of the Subthalamic Nucleus in Perceptual Decision-Making in Humans. Parkinson's Disease

Parkinson's Disease patients at least 18 years of age who will undergo placement of a deep brain stimulator

Girgis

Medtronic

A Prospective, Randomized, Multi-Center, Open-Label Pilot Study of Infuse® Bone Graft with Mastergraft® Strip and Posterior Fixation for Posterolateral Fusion (PLF) Treatment of Multi-Level Degenerative Lumbosacral Spinal Conditions
(ClinicalTrials.gov identifier: NCT03118505)
Spine-New Combined Fusion Material for Degenerative Conditions (Lumbosacral)

Patients at least 21 years of age with a degenerative lumbar spine condition requiring a posterior fusion surgery in 2-4 consecutive levels from L2-S1.

Kim

Pacira Pharmacuticals, Inc.

A Multicenter, Randomized, Double-Blind, Controlled Study of EXPAREL for Postsurgical Pain Management in Subjects Undergoing Open Lumbar Spinal Fusion Surgery Spine-Approved Drug New Use for Post-Surgical Pain Management

Patients at least 18 years of age scheduled to undergo 1-2 level open lumbar spinal fusion surgery.

Kim

Zimmer Biomet

Post-Market, Long-Term Follow Up of Mobi-C® Cervical Disc for One and Two Level Treatment of Cervical Disc Disease
(ClinicalTrials.gov identifier: NCT03077516)
Spine - Device for Cervical Disk Disease

Invitation only:  Patients who received treatment with the Mobi-C device during the pivotal trial

Kim

Investigator Initiated

Safety and Feasibility of Using Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus to Improve Cognitive Performance in Patients with Parkinson’s Disease Parkinson's Disease

Parkinson's Disease patients at least 18 years of age who have undergone placement of a deep brain stimulator

Shahlaie

Investigator Initiated

Effect of Short-Term Theta Frequency Stimulation of the Vagus Nerve on Cognition in Patients with Refractory Epilepsy: A Pilot Study Epilepsy

Epilepsy Patients at least 18 years of age with a previously implanted vagal nerve stimulator

Shahlaie

Investigator Initiated

Harvest of Neural Progenitor Cells during Shunt Surgery or External Ventricular Drain Placement Cranial Surgery - Stem Cell Harvest

Patients undergoing cranial surgery

Waldau

Investigator Initiated

Influence of Temozolomide-Induced Suppression of Adult Hippocampal Neurogenesis on Spatial Learning and Memory Neuro-Oncology

Patients age 18-90 years with a diagnosis of glioma and are being started on temozolomide treatment.

Waldau

Investigator Initiated

Spatial Memory after Aneurysmal Subarachnoid Hemorrhage Aneurysmal Subarachnoid Hemorrhage

Patients at least 18 years of age who have a history of aneurysmal subarachnoid hemorrhage

Waldau

Investigator Initiated

Prospective Transcranial Dopller Analysis of Aneurysmal Subarachnoid Hemorrhage Patients Aneurysmal Subarachnoid Hemorrhage - Observational

Patients at least 18 years of age who have a history of aneurysmal subarachnoid hemorrhage

Waldau

NIH Grant

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Trumatic Brain Injury-Observational

Patients at least 12 years of age that present to UCDMC with a moderate to severe traumatic brain injury with no pre-existing neurological disorders.

Zimmermann

 

Updated August 2017

Our experienced clinical research team evaluates new drugs, new surgical procedures or devices and new ways to use existing treatments.  We have a research nurse, research pharmacists, research coordinators and many assistants  who help our faculty find better ways to treat our patients.