Michelle Apperson, M.D., Ph.D.

Michelle L. Apperson, M.D., Ph.D.

Assistant Clinical Professor
Director, Multiple Sclerosis Program
Specialty:  Neurology

Lawrence J. Ellison Ambulatory Care Center
4860 Y St., Suite 3700
Sacramento, CA 95817
(916) 734-3588

Clinical and Research Interests

Dr. Apperson's research interests include clinical trials of novel multiple sclerosis treatments and identification of multiple sclerosis biomarkers. Dr. Apperson is conducting genetic, genomic and other biochemical blood profiling to further elucidate the relationship between genetics and environmental factors in the autoimmune etiology of multiple sclerosis.


John A. Burns School of Medicine
University of Hawaii
Manoa, Hawaii

California Institute of Technology
Pasadena, California

University of California, San Diego
La Jolla, California


University of California, Davis, Health System
Sacramento, California


John A. Burns School of Medicine
University of Hawaii
Internal Medicine

Board Certifications

American Board of Psychiatry and Neurology

Select Recent Publications 

Dias RA, Hardin KA, Rose H, Agius MA, Apperson ML, and Brass SD. Sleepiness, fatigue, and risk of obstructive sleep apnea using the STOP-BANG questionnaire in multiple sclerosis: a pilot study. Sleep Breath, 2012 Dec; 16(4):1255-65.

Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, Yang M, Raghupathi K, Novas M, Sweetser MT, Vigiletta V, Dawson KT; CONFIRM Study Infestiagors. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012 Sep 20; 367(12):1087-97. 

Magley J, Towner D, Tache V, Apperson ML. Preganancy outcome in anti-N-methyl-D-aspartate receptor encephalitis. Obstet Gynecol. 2012 Aug; 120:480-3.

Goldenholz DM, Wong VS, Bateman LM, Apperson M, Oskarsson B, Akhtar S and Wheelock V. Treatment of γ-Aminobutyric Acid B Receptor-Antibody Autoimmune Encephalitis With Oral Corticosteroids. Arch Neurol. 2012 Aug;69(8):1061-3.

Apperson ML and Agius MA. Clinical and neuroimaging assessments for research studies (including drug trials) in multiple sclerosis. Curr Protoc Neurosci. 2011 Jan; Chapter 10:Unit 10.4. 

Tian Y, Apperson ML, Ander BP, Liu D, Stomova BS, Jickling GC, Enriquez R, Agius MA, and Sharp FR. Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects. J. Neuroimmunol. 2011 Jan;230(1-2):124-9. 

Stamova BS, Apperson M, Walker WL, Tian Y, Xu H, Adamczyk P, Zhan X, Liu DZ, Anger BP, Liao IH, Gregg JP, Turner RJ, Jickling G, Lit L, and Sharp FR. Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Med Genomics. 2009 Jul;80(7):812-4.

Zhang L, Coffey S, Lua LL, Greco CM, Schafer JA, Brunberg J, Borodyaskaya M, Agius MA, Apperson M, Leehey M, Tartaglia N, Tassone F, Hagerman PJ, Hagerman RJ. FMR1 premutation in females diagnosed with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):812-4.