Translational Research in Down Syndrome

The past decade has brought renewed calls for improving quality of life outcomes for individuals with Down syndrome, the most common neurogenetic syndrome associated with intellectual disability. Indeed, these renewed demands for translational research have prompted innovation in the biobehavioral research communities. Down syndrome is a multi-system disorder Father and Childthat affects biomedical and neurodevelopmental outcomes. Congenital and acquired medical complications, including congenital heart defects, gastrointestinal issues, and sleep apnea, influence developmental trajectories in Down syndrome in impactful ways and provide opportunities for collaborations between the clinical and biomedical communities. Unraveling links between biomedical, neurological, genetic and behavioral attributes can advance our understanding of the mechanisms underlying outcomes in Down syndrome. Ultimately, these findings can support the development of therapies and intervention programming that are tailored to address specific Down syndrome-related risk factors.

 The invited speakers for the 2019 plenary sessions represent a number of disciplinary perspectives, including neuroscience, neurobiology, genetics, psychiatry, and clinical medicine, to address basic and clinical science questions related to translational research in Down syndrome. Their work represents the forefront of translational research in Down syndrome and other neurogenetic disorders, and their presentations to the Gatlinburg Conference community will serve as a rich platform for scientific discussions for all attendees.