Tony J. Simon, Ph.D. - IDDRC Investigator

Tony J. Simon, Ph.D.

Professor, Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine
UC Davis MIND Institute
2825 50th Street, Room 2341
Sacramento, CA 95817 

Phone: 916-703-0407 / Fax: 916-703-0244

Areas of Interest

Chromosome 22q11.2 deletion syndrome, (22q112, VCFS. DiGeorge), Chromosomal Disorders, Cognition, Neuroimaging, Psychopathology, Anxiety


Tony J. Simon is the Associate Director of the IDDRC and Director of the IDDRC NeuroBehavioral Analysis Core. Dr. Simon research is focused on how neurocognitive, emotional and environmental factors interact to modulate learning difficulties and psychopathology in neurodevelopmental disorders, particularly chromosome 22q11.2 deletion syndrome (22q11.2/VCFS/DiGeorge syndrome), fragile X syndrome, and sex chromosome aneuploidies.  He also leads the 22q Healthy Minds Clinic that focuses on the mind, brain and behavior aspects of 22q11.2DS. Dr. Simon is interested in developing technology based interventions in the form of video games and internet based training that can enhance functioning, reduce symptom severity and improve quality of life. Current projects are focused on understanding the neurocognitive factors underlying learning difficulties in 22q11.2DS and related disorders and the also on understanding how cognition, emotion and environment interact to modulate stress, anxiety and psychiatric disorders in 22q11.2DS.

Current IDDRC Projects

  • Visuospatial Cognitive Deficit in Del22q11.2 Syndrome, NICHD/NIH, R01 HD042974

Recent Representative Publications

Shapiro, H., Wong, L., Simon, T.J. (2013) A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome. Frontiers in Child and Neurodevelopmental Psychiatry. 4, 81. 

Angkustsiri, K., Tartaglia, N.R., Leckliter, I., Enriquez, J., Hansen, R.L., Beaton, E.A., Simon, T.J. (2012) An examination of the relationship of anxiety and intelligence to adaptive functioning of children with chromosome 22q11.2 deletion syndrome. Journal of Development and Behavioral Pediatrics. 33, 713-720 

Stoddard, J., Niendam, T., Hendren, R., Carter, C., Simon, T.J. (2010) Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome. Schizophrenia Research, 118: 118-121 

Karayiourgou, M., Simon, T.J., Gogos, J.A., (2010) 22q11.2 microdeletions: Linking DNA structural variation to brain dysfunction and schizophrenia. Nature Reviews Neuroscience, 11: 402-416 

Simon, T.J. (2008) A New Account of the Neurocognitive Foundations of Impairments in Space, Time and Number Processing in Children with Chromosome 22q11.2 Deletion Syndrome. Developmental Disabilities Research Reviews. 14, 52-58.