Janine LaSalle, Ph.D. - IDDRC Investigator
Professor, Medical Microbiology and Immunology, UC Davis Genome Center, UC Davis MIND Institute
Medical Microbiology and Immunology
One Shields Avenue
Davis, CA 95616
Phone: 530-754-7598 / Fax: 530-752-8692
Areas of Interest
Epigenetics, Autism, Rett syndrome, Prader-Willi syndrome, Duplication 15q11-q13 Syndrome, Environmental Epigenetics
Dr. LaSalle is a Professor of Microbiology and Immunology at the University of California, Davis, with memberships in the Genome Center, and the MIND Institute. Dr. LaSalle serves as Chair of the Integrative Genetics and Genomics graduate group at UC Davis. Dr. LaSalle also serves on the editorial board of the journals Human Molecular Genetics, Molecular Autism, and OA Autism and is on the Scientific Advisory boards of the International Rett Syndrome Foundation and the Dup15q Alliance. The research focus in Dr. LaSalle’s laboratory is on epigenetics of neurodevelopmental disorders, including autism, Rett, Prader-Willi, Angelman, and Dup15q syndromes. Dr. LaSalle’s laboratory uses genomic and epigenomic technologies to investigate the role of DNA methylation and MeCP2 in the pathogenesis of Rett syndrome and autism spectrum disorders. Dr. LaSalle’s lab has more recently been taking integrative genetic and epigenomic approaches to investigate to role of persistent organic pollutants such as flame retardant PBDEs and long lived PCBs and the protective effect of folate and prenatal vitamin use on the methylome.
Current IDDRC Projects
- The Role of MECP2 in Rett Syndrome, NINDS/NIH, R01NS081913-11
- Noncoding RNAs at the Heart of the Prader-Willi Locus, NINDS/NIH, R01NS076263-03
- Methylomic and genomic impacts of organic pollutants in Dup15q syndrome, NIEHS/NIH, 1R01ES021707-02
- Epigenetic Biomarkers of Autism in Human Placenta, Department of Defense, Autism, 1210491
Recent Representative Publications
Woods R, Vallero RO, Golub M, Suarez JK, Ta TA, Yasui DH, Chi L-H, Kostyniak PJ, Pessah, IN, Berman RF, LaSalle JM. 2012. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum. Mol Genet, 21:2399-2411.
Schroeder DI, Blair J, Lott P, Yu HO, Hing, D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, and LaSalle JM. 2013. The human placental methylome. Proc. Natl. Acad. Sci., 110:6037-6042.
Powell WT, Coulson RL, Crary FK, Gonzales ML, Adams S, Ach RA, Tsang P, Yamada NA, Yasui DH, Chedin F, and LaSalle JM. 2013. Topotecan stabilizes R-loops to inhibit transcription in the Prader-Willi/Angelman imprinted locus. Proc. Natl. Acad. Sci., 110:13938-13943.
Powell WT, Coulson RL, Crary FK, Wong SG, Ach RA, Tsang P, Yamada NA, Yasui DH, and LaSalle JM. 2013. A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum. Mol Genet, 22:4318-4328.
Yasui DH, Schanen NC, Aflatooni JO, Golub MS, LaSalle JM. 2014. Mice with a single nucleotide isoform-ablating Mecp2-e1 mutation recapitulate the neurologic deficits of Rett syndrome. Hum. Mol Genet., In press