RESEARCH SPOTLIGHT ON JAY V. SOLNICK, M.D., PH.D.
In 1993, while an Infectious Disease fellow at Stanford University, Dr. Solnick had the opportunity work in the laboratory of Dr. Agnes Labigne at the Pasteur Institute in Paris. "At the time, she was the only scientist in the world who was able to genetically manipulate Helicobacter pylori, and I went there to learn how. The work was hard and the initial results were disappointing. Agnes told me that 'the most important lesson I ever learned in my scientific career was just keep going'. I did, the experiments eventually worked, and I never forgot this lesson, which I have repeated to my students many times."
Dr. Solnick’s lab has been funded by the NIH since shortly after his arrival at UC Davis in 1995. "The funding climate at NIH has become extraordinarily difficult, and even very accomplished investigators are finding themselves without NIH support. I was very gratified recently to learn that our most recent R01 application was scored in the top 2%, which assures that we will be able to continue our work for another 5 years."
Dr. Solnick’s laboratory studies Helicobacter pylori, a bacterial pathogen that commonly infects the human stomach and sometimes leads to peptic ulcers or gastric cancer. They use mouse and non-human primate models, as well as in vitro cell culture, to understand how H. pylori causes disease. They also perform translational studies. For example, his lab recently led an international collaboration to use mass spectrometry to identify serum glycans that might identify those H. pylori-infected patients who are at increased risk of gastric cancer.
His lab recently discovered a novel strategy that H. pylori uses to dial up or dial down its capacity to cause inflammation—a sort of "molecular rheostat" that tunes the host response, presumably for the benefit of the pathogen. "The implication is that inflammation, the host response to control infection, is actually co-opted to serve the interests of the bacterium. They aren’t as smart as we are, but there are a lot more of them, and there is strength in numbers!"
Dr. Solnick enjoys exercising in the morning and rides his bike everywhere that he can. He also enjoys working in the garden, cooking, and playing the guitar. "My wife and I recently bought a small cabin in Mt. Shasta, and we love to hike with our devoted golden retriever, Cooper. I also have a longstanding interest in learning Spanish, which began as a medical student working in Spanish Harlem in New York. I attend a weekly conversation class at the International House in Davis and try to do the homework when I have time."
Ozcan S, Barkauskas DA, Ruhaak LR, Javier Torres J, Cooke CL, An H, Hua S, Williams CC, Dimapasoc LM, Kim J, Camorlinga-Ponce M, Rocke DM, Lebrilla C, Solnick J.V. Serum glycan signatures of gastric cancer. Cancer Prev Res, 2013 Dec 10. [Epub ahead of print]
Moore ME, Lam A, Bhatnagar S, Solnick JV. Environmental determinants of transformation efficiency in Helicobacter pylori. J Bacteriol. 2014 Jan;196(2):337-44. doi: 10.1128/JB.00633-13.
Martin, ME, Bhatnagar, S, George, MD, Paster, BJ, Canfield, DR, Eisen, JA, and Solnick, JV. The impact of Helicobacter pylori infection on the gastric mic robiota of the rhesus macaque. 2013, PLoS ONE 8(10): e76375.
Cooke CL, Torres J, Solnick JV. Biomarkers of Helicobacter pylori-associated gastric cancer. Gut Microbes. 2013 Jul 12;4(6).
Barrozo, RM, Cooke, CL, Hansen, LM, Lam, AM, Gaddy, JA, Johnson, EM, Cariaga, TA, Suarez, G, Peek, RM Jr, Cover, TL, and Solnick, JV. Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathogens, 2013, Feb;9(2):e1003189. Reviewed in Faculty of 1000
Martin, ME, Dieter, JA, Luo, Z, Baumgarth, N and Solnick, JV. Predicting the outcome of infectious diseases: Variability among inbred mice as a new and powerful tool for biomarker discovery. mBio, 2012 Oct 16;3(5):e00199-12.
Jay V. Solnick, M.D., Ph.D.
Professor of Medicine and Microbiology and Immunology
Department of Internal Medicine
Division of Infectious Diseases
Staff Scientist, California National Primate Research Center
Core Faculty Member, Center for Comparative Medicine
Research Funding News
American Federation for Medical Research
The AFMR works to support the careers of academic physician-scientists and to develop and encourage young academic and clinical researchers. Some of the ways that the AFMR works toward this mission are Professional Opportunities and Advocacy.
Additional benefits for your residents and fellows are the opportunity to present their research at a regional meeting and be eligible to apply for travel and trainee awards. Many of the academic leaders in our region attend this meeting so it is an excellent opportunity for your trainees to network as they are looking for a fellowship or faculty position. It is also an excellent chance for mentees and mentors to attend the meeting together to showcase their work. We hope you will accept our invitation to attend this meeting and encourage your faculty and trainees to submit abstracts and attend the meeting in Carmel, CA.
Please note the call for abstracts deadline is October 1, 2013. For details: http://bit.ly/14gBxf3
Furthermore, please connect with us through the AFMR LinkedIn Group, and join our Discussion Forum here: http://linkd.in/14gAxrc.
CALL FOR FELLOWSHIP APPLICATIONS:
Eligibility: Graduate students, postdoctoral fellows, and medical students and residents at member MMPC institutions
Requirements: One-page abstract application; Poster presentation on the day of the Symposium
Fellowship: Will support travel expenses and poster presentations up to $1,500
Deadline: 5PM PT, September 27, 2013. Please send the one-page abstract to Sasha Wirth (SSWirth@ucdavis.edu)
November 8, 2013
7:30 AM-12 Noon
AGR Hall, Buehler Alumni & Visitor Center