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Clinical and Translational Science Center

Clinical and Translational Science Center

About Us

Our Mission

"Building research teams of the future to improve human health"

Our Objectives

Working together as a national consortium, CTSA institutions share a common vision to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research. The CTSA program is supported by the National Center for Advancing Translational Science (NCATS), part of the National Institutes of Health.  The CTSA program has the following overriding objectives:

  1. Provide a comprehensive array of essential tools and services to spark clinical and translational research.
  2. Ensure the training of a well prepared workforce of trainees, staff, and investigators.
  3. Effectively communicate the many tools, services, and training opportunities to ensure innovative translational science advances that will improve human health.

Who We Serve

The CTSC provides a wide range of services and tools to assist research teams across the campus and with our affiliated partners:

  • UC Davis colleges, centers, and institutes
  • VA faculty
  • Community-based organizations and their constituents
  • Industry sponsors
  • Undergraduate and graduate student and their mentors, and trainees at all levels
  • Clinical research coordinators
  • Research administrators

Background

In late 2006, UC Davis was honored to be among the first 12 institutions to receive a coveted NIH Clinical and Translational Science Award (CTSA) marking an important recognition of the rich, collaborative culture at UC Davis. The $24.8 million award provided the foundation for a program that has blossomed since initiation in late 2006. During the years that have followed and the transition to the NCATS, the consortium of CTSA academic research institutions has expanded to 61 and our CTSA partners are currently located in 30 states and the District of Columbia. In 2011, the CTSC successfully competed for renewal and continues to expand our offerings in support translational research.

Initially the CTSC served as an incubator of ideas and a catalyst for partnerships at UC Davis and beyond. Today, the UC Davis CTSC offers a robust toolbox of resources that faculty, trainees, and staff across the scientific and medical spectrum can use to enhance research and improve health and health-care delivery. Whether you are a researcher, industry representative, potential scholar, or member of the community, we encourage you to visit our website and to explore the many services and resources that will benefit you and your colleagues.

Leadership

Organizational Leadership

The UC Davis CTSC has a matrix organizational structure that is collaborative in nature and reflects program elements and administrative functions. UC Davis faculty and staff serve as program leaders and manage day-to-day operations. For more information about these individuals, click here.

Administration
• Lars Berglund, M.D., Ph.D.
• Kitty Lombardo
• Christine Hotz, D.V.M., M.S.

Bioethics
• Mark Yarborough, Ph.D.

Biomedical Informatics
• Nick Anderson, Ph.D.
• Kent Anderson, M.S.
• Sam Morley, M.S.

Biostatistics
• David Rocke, Ph.D.
• Sandy Taylor, Ph.D.

Clinical Research Center
• Ted Wun, M.D.
• Nicole Hansen, R.N., M.S.N.

Community Engagement
• Sergio Aguilar-Gaxiola, M.D., Ph.D.
• MaryLou Siantz, Ph.D.
• Linda Ziegahn, Ph.D.

Education & Career Development
• Fred Meyers, M.D.
• Nick Kenyon, M.D.
• James Holmes, M.D.
• Julie Schweitzer, M.D.
• Jennifer Greenier, Ph.D.

Evaluation
• Julie Rainwater, Ph.D.
• Stuart Henderson, Ph.D.

Pilot Program
• Alice Tarantal, Ph.D.
• Cristina Davis, Ph.D.

Regulatory Knowledge and Support
• Deborah Diercks, M.D.
• Kate Marusina, Ph.D.

Translational Resources
• Alice Tarantal, Ph.D.
• Cristina Davis, Ph.D.

Message from the Director

Lars Berglund, M.D., Ph.D.

June 2011

On behalf of the UC Davis CTSC, I am pleased to share that our NIH Clinical and Translational Science Award was renewed for another 5-year period. Once one of the 12 inaugural recipients, the CTSC is now among 60 institutions in the national CTSA Consortium. Our Center provides UC Davis researchers with connections, assistance, training, resources, and tools to help translate ideas into products more efficiently.

We place a strong emphasis on outreach, both across the UC Davis campus and to other institutional and community partners throughout the Central Valley. By spreading awareness of our mission, we forge and strengthen connections that serve as resources to support high impact research. In this spirit, I invite you to read and share our new newsletter, CTSC Connections, with others. As a convenience, a link to the online version is provided on the website.

Governance

The activities and direction of the UC Davis CTSC are governed by three distinct oversight committees plus a program evaluation team:

Steering Committee

A Steering Committee meets weekly to address operations, strategy, prioritization, infrastructure, and resource management. 

Internal Advisory Board

An Internal Advisory Board provides input on CTSC resource allocation and effort.

Sergio Aguilar-Gaxiola, M.D., Ph.D.
Kent Anderson, M.S.
Nick Anderson, Ph.D.
David Asmuth, M.D.
Lars Berglund, M.D., Ph.D.
Donald Bers, Ph.D.
Klea Bertakis, M.D., M.P.H.
Cameron Carter, M.D.
Fitz-Roy Curry, Ph.D.
Cristina Davis, Ph.D.
Deborah Diercks, M.D., MSc.
Jen Greenier, Ph.D.
Nicole Hansen, R.N., M.S.N.

Sidika Kasim-Karakas, M.D.
Jana Katz-Bell, M.P.H.
John Keltner, M.D.
Nicholas Kenyon, M.D.
Chin-Shang Li, Ph.D.
Kitty Lombardo
Kent Lloyd, D.V.M., Ph.D.
Steve Martinez, M.D.
Kate Marusina, Ph.D., M.B.A.
Samuel Morley, M.S.
Tina Palmieri, M.D.
Julie Rainwater, Ph.D.
David Rocke, Ph.D.

Mary Lou de Leon Siantz, Ph.D., R.N., F.A.A.N.
David Siegel, Ph.D.
Charles Stephensen, Ph.D.
Jeanine Stiles
Alice Tarantal, Ph.D.
Teresa Tempkin R.N.C., M.S.N., ANP
Mark Underwood, M.D.
Barth Wilsey, M.D.
Ted Wun, M.D., F.A.C.P.
Mark Yarborough, Ph.D.
Heather Young, Ph.D., R.N., F.A.A.N.
Linda Ziegahn, Ph.D.

External Advisory Board

The External Advisory Board meets annually to review the overall program. The outcomes of this meeting are included in the Annual Progress Report.

 CTSC External Advisory Board 2013 

Bo Angelin, M.D., Ph.D.
Professor of Clinical Metabolism, Karolinska Institutet
Department of Endocrinology, Metabolism & Diabetes
Karolinska University Hospital Huddinge
Stockholm, Sweden

 
 

Michael Becich, M.D., Ph.D.
Chairman, Department of Biomedical Informatics
Professor of Biomedical Informatics, Pathology,
Information Sciences, and Telecommunications
University of Pittsburgh School of Medicine
Pittsburgh, PA

  Robert Califf, M.D.
Vice Chancellor for Clinical Research
Director, Duke Translational Medicine Institute
Duke University Medical CenterDurham, NC
 

Willard Dere, M.D.
Senior Vice President, International Chief Medical Officer
Amgen Limited
Uxbridge, UK

  Gary Firestein, M.D.
Professor of Medicine
Dean and Associate Vice Chancellor of Translational Medicine
Director, Clinical and Translational Research Institute
UC San Diego Health Sciences
La Jolla, CA
 

Henry Ginsberg, M.D.
Irving Professor of Medicine
Associate Dean, Clinical and Translational Research
Director, Irving Institute for Clinical and Translational Research
Columbia University College of Physicians and Surgeons
New York, NY

 

Barbara Howard, Ph.D.
Senior Scientist, MedStar Health Research Institute
Professor of Medicine, Georgetown University School of Medicine
Hyattsville, MD

 

Julianne Imperato-McGinley, M.D.
Associate Dean, Translational Research and Education
Program Director, Clinical and Translational Science Center
Abby Rockefeller Mauzé Distinguished Professor of Endocrinology in Medicine
Chief, Division of Endocrinology
Weill Cornell Medical College
New York, NY

 

Program Evaluation

The CTSC Evaluation team monitors and evaluates the CTSC and its components. This program assesses the impact of the CTSC on clinical and translational research capabilities and on its success in forming the clinical and translational research teams of the future. The evaluation team provides consultation and oversight for CTSC Training Programs including the CTSC T32, MCRTP, K12 and CTSC-affiliated programs, such as BIRWCH and HHMI. In addition, the Evaluation program provides evaluation services for other programs such as the Betty Irene Moore School of Nursing, School of Medicine Rural-PRIME (PRograms In Medical Education), and the Western Center for Agricultural Health and Safety. For specific information about the Evaluation, contact Julie.rainwater@ucdmc.ucdavis.edu or stuart.henderson@ucdmc.ucdavis.edu.

CTSC Service and Program Details

The CTSC provides key services to investigators, trainees, and staff to facilitate clinical and translational research. Investigators who wish to include CTSC services and programs in their grant applications may use the following descriptive language. It is important to ensure that the costs of any services needed are obtained in advance of application for your research are included in the budget submitted. The best way to obtain the necessary information for submitted budgets and budget justifications are through an Application for Resource Use or you can contact individual program managers for additional information. Investigators will need a Kerberos ID and provide some basic information in order to process the request.

Areas of Focus

To see a general description of the CTSC Areas of Focus, please click here.

Describing the CTSC in a Grant Application

UC Davis Clinical and Translational Science Center (CTSC)

The UC Davis CTSC was established in October 2006 with a $24.8 million Clinical and Translational Science Award from the NIH. The CTSC, now one of 61 NIH-supported centers nationally, is focused on enhancing the study of human health and disease, and bringing new treatments more rapidly to patients and communities (www.ucdmc.ucdavis.edu/ctsc/). The CTSC, physically housed in a specially renovated 16,000 sq. ft. facility on the Sacramento campus, draws talent and leadership from departments and divisions across the Davis and Sacramento campuses as well as community and institutional partners in the region. The CTSC is an academic home for innovative and collaborative research across the UC Davis campus, and a part of a national consortium bridging basic, translational, and clinical research using a transformative approach. The consortium is designed to: (1) encourage the development of new methods and techniques to enhance clinical and translational research, (2) improve training and mentoring to ensure that new investigators are educated in the conduct of clinical and translational research, (3) enhance the ability of investigators to navigate the increasingly complex research system, (4) design new and improved clinical research informatics tools, (5) assemble multidisciplinary teams that cover the spectrum of clinical and translational research, and (6) forge new partnerships with private and public entities that will help transform the clinical enterprise. A key feature of the UC Davis CTSC is an education program focused on "team science" and an extensive collaborative culture across UC Davis schools, colleges, and centers. The UC Davis CTSC has implemented several programs to enhance communication, encourage sharing, facilitate research, and train multidisciplinary teams that will conduct clinical and translational research in the future. Key programs in the CTSC include the following:  Biomedical Informatics; Research Education, Training, and Career Development; Translational Technologies, Methodologies, and Resources;  Pilot Translational and Clinical Studies; Research Design, Biostatistics, and Clinical Research Ethics; Regulatory Support; the Clinical Research Center; and Community Engagement. Through these programs the UC Davis CTSC transforms research and aids in supporting and facilitating new collaborative scientific discoveries that will bring new techniques and therapies into medical practice, and help to solve complex medical problems.

Biomedical Informatics

The Biomedical Informatics team helps develop strategies to manage clinical and translational research data and maintains a registry of volunteers. Programmers are available to assist investigators with database design and management, secure data sharing, and electronic data capture. In addition, there is expertise available to help develop data specifications and consistent terminology, extract cohorts of de-identified data to establish study feasibility, provide cohorts of potential study candidates from electronic medical records and aggregate databases, and assist in preparation of a data set for statistical analysis. Through the Biomedical Informatics program, researchers have access to Volunteer Registry, SciVal, Cohort Discovery, REDCap, Velos, and Data Explorer.

Research Design, Biostatistics and Clinical Research Ethics

The Design, Biostatistics, and Clinical Research Ethics program strengthens research plans through study design, analysis, and consultation. Expertise is available to help develop protocols, statistical plans, data safety monitoring plans, data analysis, and contribute to the statistical sections of grant applications, abstracts, and manuscripts.  

Clinical Research Center

The CTSC Clinical Research Center (CCRC) is a main component of the Clinical Research Resources and Facilities program. The CCRC has an outpatient clinic in TICON I and provides in/outpatient services at the VA Northern California Health Care System. The in/outpatient clinic  is an 8,000 sq. ft., nine-bed unit that provides clinical research facilities and patient-oriented resources and services, including nursing, nutrition, phlebotomy, laboratory, and physiological assessment components. Resources for patient-oriented research, as well as flexible, mobile research personnel are available for investigators and staff. The CCRC has collaborative research relationships with the Western Human Nutrition Research Center on the Davis campus, the M.I.N.D. Institute, Shriner’s Hospital for Children Northern California, and the UC Davis Comprehensive Cancer Center. The CCRC is able to provide continuous 24 hours/day, 7 days/week support for inpatient and outpatient protocols.

Community Engagement

The Community Engagement program is a major resource linking investigators and community partners. The program is focused on implementing the CTSC mission of building capacity and infrastructure for clinical and translational research among investigators, health care providers, and community-based organizations. Partners include California health agencies and elected officials around health and healthcare issues. The CTSC has built capacity for community-engaged research and includes a research agenda responsive to community priorities by implementing a Research and Education Community Advisory Board and a consultation service that is aimed at investigators that conduct practice-based research, and at community members seeking academic research expertise.

Education, Training and Career Development

The goal of this program is to create a cadre of multidisciplinary clinical and translational researchers through effective research education, training, and career development. Trainees and junior faculty acquire state-of-the-art multidisciplinary skills in clinical and translational research through three training mechanisms: an innovative T32 pre-doctoral program in “team science” for medical and graduate students; an enhanced K30 Mentored Clinical Research Training Program for junior faculty; and a K12 Mentored Career Development Program for junior faculty. These training programs are also highly integrated with several other UC Davis training programs in translational research  including the NIH-funded Building Interdisciplinary Research Careers in Women's Health (BIRCWH) program; the Howard Hughes Medical Institute (HHMI)-funded Integrating Medicine into Basic Science Program; the UC Davis Stem Cell Training Program supported by the California Institute for Regenerative Medicine (CIRM); the Agency for Healthcare Research and Quality (AHRQ) Primary Care Outcomes Research (PCOR) training program; and NIH-supported K12 programs in Emergency Medicine and Oncology.

Evaluation

The CTSC Evaluation team monitors and evaluates the CTSC and its components. This program assesses the impact of the CTSC on clinical and translational research capabilities and on its success in forming the clinical and translational research teams of the future. The evaluation team provides consultation and oversight for CTSC Training Programs including the CTSC T32, MCRTP, K12 and CTSC-affiliated programs, such as BIRWCH and HHMI. In addition, the Evaluation program provides evaluation services for other programs such as the Betty Irene Moore School of Nursing, School of Medicine Rural-PRIME (PRograms In Medical Education), and the Western Center for Agricultural Health and Safety.

Pilot Program

The Pilot Translational and Clinical Studies program aims to spark innovative and collaborative scientific endeavors by supporting and facilitating robust new research paradigms, technologies, and tools, and through partnerships that enhance team science. The CTSC has circulated calls throughout the campus community for applications on targeted topics, and has maximized and leveraged opportunities throughout UC Davis including other NIH-supported centers and programs. All funded investigators and the titles of their projects are listed on the CTSC website to highlight their success and innovation. identification of transformative outcomes. In addition, potential new research opportunities are noted and, where appropriate, investigators are directed to the Translational Technologies, Methodologies, and Resources program to determine potential commercialization of their work.

Translational Technologies, Methodologies, and Resources

The overriding objective of the Translational Technologies, Methodologies, and Resources program is to serve as a facilitator, encourage investigators to form multidisciplinary partnerships, and link investigators with the resources needed to undertake novel studies. To implement these objectives, the program provides ready access to core services and facilities through the Facilities, Cores, and Resources website, organizes collaborative workshops and symposia on key thematic areas that are frequently associated with calls for pilot project applications, and supports local and national translational research initiatives.

Regulatory Knowledge and Support

The Regulatory Knowledge and Support program provides assistance to investigators, scholars, and staff with the regulations and best practices that guide clinical research. The Clinical Trial Resource Group facilitates compliance with Good Clinical Practice, local, state, and federal regulations (e.g.,IRB, HIPAA, Informed Consent, and FDA), Medicare and private payer cost analysis, budgeting and billing, and resources to help monitor, mentor, and foster quality assurance. The Program leads SoCRA certified training opportunities including a diverse range of topics and provides a Coordinator Training Program,  Informed consent “Bootcamp,” and “Navigating the Clinical Trials Administrative Process.”

Citing the CTSC Grant

Investigators must cite the CTSC grant in all publications that result from any support received from the CTSC, including the use of CTSC resources:

"The project described was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1 TR 000002." 

  • TL1 (T32) Scholars add: "and linked award TL1 TR 000133."
  • KL2 (K12) Scholars add: "and linked award KL2 TR 000134."

Note: The NIH requires a Pub Med Central ID (PMCID) for any publications that have benefited from the resources of the CTSC. For any publication listed on an NIH biosketch or publication listing or progress report that is requested by the NIH, please ensure the PMCID number is listed after the reference. NIH will not acknowledge CTSC contributions in any publications without a PMCID number.