Alice F. Tarantal, Ph.D.
Primate Center Lab
Dr. Tarantal’s research program includes the following areas of translational research:
- Gene therapy
- Stem and progenitor cell therapies
- Pediatric models of human disease
- Fetal: maternal microchimerism
- In vivo imaging applications
Projects focus on hematopoietic, mesenchymal, endothelial, and embryonic stem cells for tissue regeneration and repair and transplantation.
The Center for Fetal Gene Transfer for Heart, Lung, and Blood Diseases conducts research on crucial questions in gene therapy for the fetus and infant.
The Center of Excellence in Translational Human Stem Cell Research consists of projects that encompass central themes of cell expansion and reconstitution, transplantation and cell fate, pediatric nonhuman primate models, and in vivo imaging.
Tarantal AF and Skarlatos SI. Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases: An NHLBI resource for the gene therapy community. Human Gene Therapy 2012 Nov;23:1130-1135.
Trnka P, Hiatt MJ, Tarantal AF, and Matsell DG. Congenital urinary tract obstruction: defining markers of developmental kidney injury. Pediatric Research 2012 Nov;72:446-454.
Tarantal AF, Giannoni F, Lee CCI, Wherley J, Sumiyoshi T, Hollis R, Martinez M, Leapley A, Kahl C, Louie SG, and Kohn DB. Non-myeloablative conditioning regimen to increase engraftment of gene-modified hematopoietic stem cells in young rhesus monkeys. Molecular Therapy 2012 May;20:1033-1045.
Shelley WC, Huang L, Critser PJ, Leapley AC, Mead LE, Zeng P, Prater D, Ingram DA, Tarantal AF, and Yoder MC. Changes in the frequency and in vivo vessel-forming ability of rhesus monkey circulating endothelial colony-forming cells across the lifespan (birth to aged). Pediatric Research 2012 Feb;71:156-161.
Tarantal AF, Lee CCI, Batchelder CA, Christensen JE, Martinez ML, Prater D, and Cherry SR. Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal monkeys. Molecular Imaging and Biology 2012 Apr;14:197-204.
Wang L, Bell P, Lin J, Calcedo R, Tarantal AF, and Wilson JM. AAV8-mediated hepatic gene transfer in infant rhesus monkeys (Macaca mulatta). Molecular Therapy 2011 Nov;19:2012-2020.
Nakayama KH, Batchelder CA, Lee CCI, and Tarantal AF. Renal tissue engineering with decellularized rhesus monkey kidneys: Age-related differences. Tissue Engineering Part A 2011 Dec;17:2891-2901.
Nakayama KH, Batchelder CA, Lee CCI, and Tarantal AF. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Engineering Part A 2010 Jul;16:2207-2216.
Ivanova L, Hiatt MJ, Yoder MC, Tarantal AF, and Matsell DG. Ontogeny of CD24 in the human kidney. Kidney International 2010 Jun;77:1123-1131.
Batchelder CA, Lee CCI, Martinez ML, and Tarantal AF. Ontogeny of the kidney and renal development in the rhesus monkey (Macaca mulatta). Anatomical Record 2010 Nov;293:1971-1983.
Nakayama KH, Batchelder CA, Lee CCI, and Tarantal AF. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Engineering 2010 Jul;16:2207-2216.
Lee CCI, Christensen J, Yoder MC, and Tarantal AF. Clonal analysis and hierarchy of human bone marrow mesenchymal stem and progenitor cells. Experimental Hematology 2010 Jan;38:46-54.
Tarantal AF and Lee CCI. Long-term luciferase expression monitored by bioluminescence imaging after AAV-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta). Human Gene Therapy 2010 Feb;21:143-148. (Cover and Commentary)
Batchelder CA, Lee CCI, Matsell DG, Yoder MC, and Tarantal AF. Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors. Differentiation 2009 Jul;78:45-56. (Cover)
Tarantal AF, Lee CCI, and Itkin-Ansari P. Real-time bioluminescence imaging of macroencapsulated fibroblasts reveal allograft protection in rhesus monkeys (Macaca mulatta). Transplantation 2009 Jul 15;88:38-41.
Huang J, Lee CCI, Sutcliffe JL, Cherry SR, and Tarantal AF. Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-PTSM for microPET. Molecular Imaging 2008 Jan-Feb;7:1-11.
Hacia JG, Lee CC, Jimenez DF, Karaman MW, Ho VV, Siegmund KD, and Tarantal AF. Age-related gene expression profiles of rhesus monkey bone-marrow derived mesenchymal stem cells. Journal of Cellular Biochemistry 2008 Mar 1;103:1198-1210.
Butt MJ, Tarantal AF, Jimenez DF, and Matsell DG. Collecting duct epithelial-mesenchymal transition in fetal urinary tract obstruction. Kidney International 2007 Oct;72:936-944. (Cover)
- CHA400, Development, Gross and Radiographic Anatomy
- CLH220, Basics of Stem and Progenitor Cells
- CLH221, Literature in Stem Cell Biology
- Mentored Clinical Research Training Program - Pre-Clinical Models Curriculum
- Scientific Director, UC Davis CIRM Stem Cell Training Program
- Chair, Designated Emphasis in Stem and Progenitor Cells
- 2004/05 School of Medicine Faculty Award
- National Institutes of Health
- California Institute for Regenerative Medicine