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UC Davis Comprehensive Cancer Center

UC Davis Comprehensive Cancer Center

Brain and Neurological Cancers

News & Features

Dr. Laura Marcu © 2010 UC Regents 

Researcher Spotlight: Laura Marcu — Bringing new technology to brain cancer patients  

Dr. Marcu has developed a new device and technique for distinguishing, with pinpoint accuracy, normal from malignant brain tissue while the patient is still on the operating table.

New Patient Support

Peer Navigator Program 

Peer navigator program provides one-to-one peer support  

This special program matches newly-diagnosed cancer patients with cancer survivors.

Related Resources

neuronal cancer cellThe brain has three major parts. The cerebrum, the largest part, is at the top of the head, and controls thinking, learning, problem solving, emotions, speech, reading, writing and voluntary movement. The cerebellum is near the middle of the back of the head, and controls movement, balance, and posture. The brain stem connects the brain to the spinal cord, just above the back of the neck, and controls breathing, heart rate, and the nerves and muscles used in seeing, hearing, walking, talking and eating.

Brain tumors are formed by abnormal growths and can appear in different areas of the brain. Benign (not cancerous) tumors may grow and press on nearby areas of the brain, but rarely spread into other tissues. Malignant (cancerous) tumors are likely to grow quickly and spread into other brain tissue. A tumor that grows into or presses on an area of the brain may stop that part of the brain from working the way it should, whether the tumor itself is benign or malignant, and will then require treatment. The most common type of brain tumor seen does not originate from the brain tissue itself, but rather are metastases from extracranial cancers such as lung cancer and breast cancer.

The UC Davis Comprehensive Cancer Center is a regional treatment center for adults and children with tumors of the brain and spinal cord.  It also offers patients access to a large number of pediatric and adult clinical trials of investigational treatments.

Risk Factors

The cause of most adult brain tumors is unknown.

The following conditions may increase the risk of developing certain types of brain tumors:

Researchers are studying whether using cell phones, having had a head injury, or having been exposed to certain chemicals at work or to magnetic fields are important risk factors. Studies have not shown consistent links between these possible risk factors and brain tumors, but additional research is needed.

Sources: National Cancer Institute and UC Davis Comprehensive Cancer Center 

Signs and Symptoms

The symptoms caused by a brain tumor depend on where the tumor formed in the brain, the functions controlled by that part of the brain, and the size of the tumor. Headaches and other symptoms may be caused by adult brain tumors. Other conditions may cause the same symptoms. A doctor should be consulted if any of the following problems occur:

Brain Tumors 

  • Morning headache or headache that goes away after vomiting
  • Frequent nausea and vomiting
  • Vision, hearing, and speech problems
  • Loss of balance and trouble walking
  • Weakness on one side of the body
  • Unusual sleepiness or change in activity level
  • Unusual changes in personality or behavior
  • Seizures

Spinal Cord Tumors 

  • Back pain or pain that spreads from the back towards the arms or legs
  • A change in bowel habits or trouble urinating
  • Weakness in the legs 
  • Trouble walking              

Sources: National Cancer Institute and UC Davis Comprehensive Cancer Center 

Diagnosis

If you have symptoms that suggest a brain tumor, your doctor will give you a physical exam and ask about your personal and family health history. You may have one or more of the following tests:

  • Neurologic exam: Your doctor checks your vision, hearing, alertness, muscle strength, coordination, and reflexes. Your doctor also examines your eyes to look for swelling caused by a tumor pressing on the nerve that connects the eye and the brain.
  • MRI: A large machine with a strong magnet linked to a computer is used to make detailed pictures of areas inside your head. Sometimes a special dye (contrast material) is injected into a blood vessel in your arm or hand to help show differences in the tissues of the brain. The pictures can show abnormal areas, such as a tumor.
  • CT scan: An x-ray machine linked to a computer takes a series of detailed pictures of your head. You may receive contrast material by injection into a blood vessel in your arm or hand. The contrast material makes abnormal areas easier to see. Your doctor may ask for other tests:
    • Angiogram: Dye injected into the bloodstream makes blood vessels in the brain show up on an x-ray. If a tumor is present, the x-ray may show the tumor or blood vessels that are feeding into the tumor.
  • Spinal tap: Your doctor may remove a sample of cerebrospinal fluid (the fluid that fills the spaces in and around the brain and spinal cord). This procedure is performed with local anesthesia. The doctor uses a long, thin needle to remove fluid from the lower part of the spinal column. A spinal tap takes about 30 minutes. You must lie flat for several hours afterward to keep from getting a headache. A laboratory checks the fluid for cancer cells or other signs of problems.
  • Biopsy: The removal of tissue to look for tumor cells is called a biopsy. A pathologist looks at the cells under a microscope to check for abnormal cells. A biopsy can show cancer, tissue changes that may lead to cancer, and other conditions. A biopsy is the only sure way to diagnose a brain tumor, learn what grade it is, and plan treatment.  Surgeons can obtain tissue to look for tumor cells in two ways:
    • Biopsy at the same time as treatment: The surgeon takes a tissue sample when you have surgery to remove part or all of the tumor.
    • Stereotactic biopsy: You may get local or general anesthesia and wear a rigid head frame for this procedure. The surgeon makes a small incision in the scalp and drills a small hole (a burr hole) into the skull. CT or MRI is used to guide the needle through the burr hole to the location of the tumor. The surgeon withdraws a sample of tissue with the needle. A needle biopsy may be used when a tumor is deep inside the brain or in a part of the brain that can't be operated on.

However, if the tumor is in the brain stem or certain other areas, the surgeon may not be able to remove tissue from the tumor without harming normal brain tissue. In this case, the doctor uses MRI, CT, or other imaging tests to learn as much as possible about the brain tumor.

Sources: National Cancer Institute and UC Davis Comprehensive Cancer Center 

Treatment

Our highly trained, experienced neurosurgeons, oncologists, nurses and support staff have helped many hundreds of patients from throughout California, Oregon and Nevada overcome neurological cancers.  Through our laboratory and clinical research programs, we continue to offer patients access to the most advanced treatments.

Our specialists are backed by the most advanced technologies and techniques available in neurologic oncology, including:

  • Computer-generated, image-guided surgical navigation systems, enabling neurosurgeons to operate with more precision and less risk
  • Stereotactic radiosurgery, a minimally invasive approach that destroys tumors painlessly using highly focused beams of radiation
  • State-of-the-art linear accelerators and three-dimensional conformal treatment planning for radiation therapy
  • Multidisciplinary treatment combining radiation with surgery and chemotherapy
  • The Gamma Knife, a tool that directs highly focused beams of radiation at a specific site in your brain

UC Davis Comprehensive Cancer Center also offers patients access to a large number of pediatric and adult clinical trials of investigational treatments.  For example, UC Davis physicians are evaluating drugs that may make brain tumors more susceptible to radiation therapy.

Sources: National Cancer Institute and UC Davis Comprehensive Cancer Center 

Your Team

Neurosurgery

James E. Boggan, M.D.
Professor and Acting Chair of Neurological Surgery
Co-director of the Center for Skull-Base Surgery
Co-director of the National Science Foundation (NSF) Center for Biophotonics

Kiarash Shahlaie, M.D, Ph.D.
Assistant Professor of Neurological Surgery


Diagnostic Radiology

Gary Caputo, M.D.
Professor of Radiology and Chief of Cardiovascular Imaging

Richard Latchaw, M.D.
Professor of Radiology and Chief of Neuroradiology


Interventional Radiology

John McGahan, M.D.
Professor of Radiology


Medical Oncology

Robert O'Donnell, M.D., Ph.D.
Professor of Medicine, Hematology and Oncology


Pediatric Brain and Neurological Cancer

Jonathan M. Ducore, M.D., M.P.H.
Chief of Pediatric Hematology and Oncology
Professor, Clinical Pediatrics
Medical Director of the Pediatric Infusion Center
Co-Director of the Hemophilia Treatment Center


Radiation Oncology

Richard Valicenti, M.D., M.A.
Professor
Department Chair of Radiation Oncology

Ruben Fragoso, M.D., Ph.D.
Assistant Professor

Shyam Rao, M.D., Ph.D.
Assistant Professor

Support

UC Davis Comprehensive Cancer Center is dedicated to caring for the whole patient.  We offer: