Thomas Jue, Ph.D.
Professor
4323 Tupper Hall
Davis Campus
Ph: 530-752-4569
e-mail

Dr. Jue applies nuclear magnetic resonance (NMR) spectroscopic/imaging and physiological techniques to study protein structure-function and metabolic regulation in vivo. His current research focuses on the metabolic regulation of muscle in terrestrial and marine organisms 2) the function of myoglobin (Mb) in the cell, especially with respect to fatty acid modulation 3) the impact of cellular architecture on biomolecular diffusion and reaction 4) the altered biochemical mechanism leading from type 2 diabetes to a dementia prevalence 5) the mechanism allowing sialic acid supplementation to improve cognition 6) the biochemical alteration underlying the pathogenesis of chronic traumatic encephalopathy.

Book

Handbook of Modern Biophysics (Series Editor)

Vol 1: Jue, T. Fundamental Concepts in biophysics, Humana Press, 2009.

Vol 2: Jue, T., Risbud, S., Longo, M. L., Faller, R., Biomembrane Frontiers, Humana Press, 2009.

Vol 4: Jue, T., Biomedical Applications of Biophysics, Humana Press, NY, 2010

Vol 3: Masuda, K. and Jue, T., Application of Near Infrared Spectroscopy in Biomedicine, Springer US, 2013

Vol 5: Jue, T., Modern Tools of Biophysics, Springer-Verlag, NY, 2017

 

Journal Articles

Bendahan, D., Chatel, B, and Jue, T. Comparative NMR and NIRS analysis of oxygen dependent metabolism in exercising finger flexor muscles, 2017 Am. J. Physiology  DOI: 10.1152/ajpregu.00203.2017

Jue, T., Shih, L., Chung, Y., Differential interaction of myoglobin with select fatty acids of carbon chain lengths C8 to C16, Lipids, 2017. DOI 10.1007/s11745-017-4272-z

Jue, T., Simond, G., Wright, T. J., Shih, L., Chung, Y., Sriram, R., Kreutzer, U., and Davis, R., Effect of fatty acid interaction on Mb oxygen affinity and triglyceride metabolism, J. Physiol. & Biochem, 2017.  doi:10.1007/s13105-017-0559-z

Masuda, K., Jue, T., Hamidie, R.D.R., Mitochondrial biogenesis induced by exercises and nutrients: Implication for performance and health benefits, Indonesian J of Sci & Tech, 2, 99-107, 2017.  DOI: http://dx.doi.org/10.17509/ijost.v2i2

Takura, H., Ojino, M., Jue, T., Yamada, T., Furuchi, Y., Hashimoto, T., Iwase, S., and Masuda, K. Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion, Physiol. Reports, 5 (2), 1-10, 2017. e13112. doi: 10.14814/phy2.13112.

Yamada, T., Takakura, H., Jue, T. Hashimoto, T. Ishizawa, R. Furuichi, Y. Kato, Y., Iwanaka, N. Masuda, K. Myoglobin and the regulation of mitochondrial respiratory chain complex IV. J. Physiol., 594, 483-495, 2016. doi: 10.1113/JP270824.

Shih, L., Chung, Y., Sriram, R., and Jue, T. Interaction of myoglobin with oleic acid. Chem Phys Lipids, 191, 115-122, 2015. doi: 10.1016/j.chemphyslip.2015.07.010.

Park, J.M., Josan, S., Mayer, D., Hurd, R. E., Chung, Y., Bendahan, D., Spielman, D. M., and Jue, T., Hyperpolarized 13C NMR Observation of Lactate Kinetics in Skeletal Muscle, J Exp Biol, 18,3308-3318,2015. DOI: 10.1113/JP270824.

Jue, T., Measuring Intracellular Oxygenation with the Myoglobin Signals, Encyclopedia of Magnetic Resonance, ed by John Griffiths and Paul Bottomley, John Wiley & Sons, 4, 635-642, 2015. DOI: 10.1002/9780470034590.emrstm1452.

Takakura, H., Furuichi,Y.Yamada, T., Jue, T., Ojino, M., Hashimoto, T., Iwase, S., Hojo, T., Izawa, T., Masuda, K., Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle, Scientific Report, 5, 9403, 1-6, 2014. doi:10.1038/srep09403.

Shih, L., Chung, Y., Sriram, R., and Jue, T., Palmitate Interaction with Physiological States of Myoglobin. Bioch BiophyActa, 1840, 656-666, 2014. DOI: 10.1016/j.bbagen.2013.10.028.

Yamada, T. Yasuro, F., Hisashi, T., Hashimoto, T. Hanai, Y., Jue, T, and Masuda, K., Interaction between myoglobin and mitochondria in rat skeletal muscle, J. Appl. Physiol., 114(4):490-7, 2013. doi: 10.1152/japplphysiol.00789.2012.

Sriram, R. Lagerstedt, J.O., Petrolova, J., Samardzic, H. Kreutzer, U., Xie, Hongtao, Kaysen, G. A., Desreux, J.F., Thonon, D. F., Jacques, V., Van Loan, M., Rutledge, J. C., Oda, M. N., Voss, J. C., and Jue, T. Imaging apolipoprotein AI in vivo. NMR in Biomedicine 24, 916-24, 2011. doi: 10.1002/nbm.1650.

Gros, G., Wittenberg, BA, and Jue, T. Myoglobin’s old and new clothes: form molecular structure to function in living cells. J. Exp. Biol 213: 2713-2725, 2010. doi: 10.1242/jeb.043075.

Tomita, A., Kreutzer, U., Adachi, S., Koshihara, SY, and Jue, T. 'It's hollow': the function of pores within myoglobin. J. Exp. Biol. 213: 2748-2754, 2010. doi: 10.1242/jeb.042994.

Takakura, H., Masuda, K., Hashimoto, T., Iwase, S., and Jue, T. Quantificatiion of myoglobin deoxygenation and intracellular partial pressure of O2 during muscle contraction during haemoglobin-free medium perfusion, Exp. Physiol. 95, 630-640, 2010. doi: 10.1113/expphysiol.2009.050344.

Xie, H., Kreutzer, U., and Jue, T. Oximetry with the NMR signals of hemoglobin Val E11 and Tyr C7. Eur J Appl Physiol. 107, 325-33, 2009. DOI 10.1007/s00421-009-1125-3.

Sriram, R., Kreutzer, U., Shih, L., Jue, T. Interaction of fatty acid with myoglobin. FEBS Lett, 582(25-26): 3643-9, 2008. doi: 10.1016/j.febslet.2008.09.047.

Ponganis, P. J., Kreutzer, U., Stockard, T. K., Lin, P. C., Sailasuta, N., Tran, T. K., Hurd, R., Jue, T. Blood flow and metabolic regulation in seal muscle during apnea. J Exp Biol, 211 (Pt 20): 3323-32, 2008. doi: 10.1242/jeb.018887.

Lin, P. C., Kreutzer, U., Jue, T. Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture. Biophys J, 92(7): 2608-20, 2007. doi: 10.1529/biophysj.106.094458.

Lower Division Courses

First Year Seminar (FYS) Trump's Immigration Ban, Chinese Exclusion Acts, and the Politics of Black Death

Upper division courses

  • BCM 192 Internship in Biological Chemistry
  • BCM 198 Group Study
  • BCM 199 Special Study for Advanced Undergraduates

Graduate courses

  • BCM 214 Molecular Medicine
  • BCM 231 Biomedical NMR (same as BPH 231)
  • BCM 291 Human Genetics Seminar
  • BCM 298 Group Study
  • BCM 299 Research
  • BPH 200B Current Techniques of Biophysics

Professional courses for medical students

  • BCM 410A Molecular and Cell Biology
  • BCM 410B Cell Biology and Metabolism
  • BCM 414 Molecular Medicine
  • BCM 497 Tutoring in Biological Chemistry
  • BCM 498 Group Study
  • BCM 499 Research

  • Handbook of Modern Biophysics