Skip to main content
Department of Urology

Department of Urology

Examples of Dr. Low’s Research

 

Rapid onset renal deterioration in an adult with silent ureteropelvic junction obstruction. 

Hellenthal NJ, Thomas SA, Low RK.
Indian J Urol. 2009 Jan;25(1):132-3.

Abstract
We report a case of a rapid renal deterioration due to ureteropelvic junction obstruction (UPJO) in an asymptomatic woman with prior normal diuretic renography. This case illustrates "silent" renal obstruction and the inability of diuretic renography in detecting significant renal obstruction. This case may favor close surveillance of any adult patient with potential UPJO, especially those with underlying renal disease or solitary kidney.

 

Use of a surgical helmet system to minimize splash injury during percutaneous renal surgery in high-risk patients. 

Eandi JA, Nanigian DK, Smith WH, Low RK.
J Endourol. 2008 Dec;22(12):2655-6.

Abstract
The transmission risk to surgeons performing percutaneous renal surgery on patients who are infected with human immunodeficiency virus/acquired immunodeficiency syndrome, hepatitis B, or hepatitis C is unknown. A recent study found 55% of surgeons' masks contain evidence of blood splash contamination after percutaneous nephrolithotomy. While the risk of infectious disease transmission to the surgeon after mucocutaneous exposure is unknown, the incapacitating disease these pathogens cause can have a devastating and permanent effect on a surgeon's career. We describe our use of a surgical helmet system when performing percutaneous renal surgery on high-risk patients to minimize risk of splash injury and transmission of blood-borne pathogens.

 

Evaluation of the impact and need for use of a safety guidewire during ureteroscopy.

Eandi JA, Hu B, Low RK.
J Endourol. 2008 Aug;22(8):1653-8.

Abstract
BACKGROUND AND PURPOSE:
The routine use of a "safety" guidewire adjacent to the ureteroscope during upper tract endoscopy is advocated in surgical texts and by many endourologists. Our experience has led us to theorize that a safety guidewire complicates ureteroscopy by providing resistance to introduction of the endoscope and by creating an obstruction to ureteroscopic instrumentation. To examine our theory, we developed a porcine animal model to evaluate the impact of the presence of a safety guidewire and reviewed our clinical experience, which routinely does not use a safety guidewire during ureteroscopy.

PATIENTS AND METHODS: An ex vivo model was created using the excised urinary tract of freshly slaughtered pigs. The forces needed to advance both a semirigid and flexible ureteroscope in the ureter were measured with and without the presence of a 0.035-inch safety guidewire. The clinical records of all patients undergoing ureteroscopy over a 4-year period were reviewed.

RESULTS: On average, an additional 12 and 20 g of force were needed to introduce the semirigid and flexible ureteroscope when a guidewire was present. For the chosen study period, 361 patients underwent ureteroscopic procedures without the placement of a safety guidewire. No patient experienced an intraoperative complication related to the absence of a safety wire.

CONCLUSIONS: The presence of a safety guidewire adjacent to the endoscope inhibits passage of the ureteroscope in an in vitro animal model. Technologic advancements in ureteroscope design and use of the holmium laser lithotrite minimize ureteral trauma and obviate the need for routine use of a safety wire during ureteroscopy.