""
UC Davis Medicine - Logo
The institution's principal publication for alumni, friends and physicians.
""
Horizontal boundary
""
""
"" "" ""
  N E W S  
"" "" ""
"" Healthy aging summits win national award ""
""

 

""
"" Death finds handgun buyers ""
""

 

""
  Patients, doctors talk online  
""

 

""
  Instruction and permission in eye/brain development  
""

 

""
  Grant targets minority youth  
""

 

""
  Celebration Gala for cancer research set  
     
  Metastatic prostate cancer: common, deadly, costly  
     
  New cardiac cath suites  
     
  Hospital switches to digital x-ray  
     
  Insurance no barrier to cancer clinical trials  
     
  Redirecting frequent users of emergency room  
     
  Retesting of mammograms unnecessary for some  
     
  UC Davis grads find 'match'  
     
  Student wins grant  
Vertical Seperator Line
Summer 2003 Issue
""
NEWS
"" ""
""
"" ""
"" ""
 
""

INSTRUCTION AND PERMISSION IN EYE/BRAIN DEVELOPMENT

UC Davis researchers reported in a spring issue of the journal Science that neuronal activity in the eye permits eye-specific connections to the brain, contrary to the conventional view of how connections form between the optic nerves and the brain.

Early in development, retinal cells show activity long before eyes are exposed to light. At the same time, optic nerves grow from the left and right eyes into the brain and form separate "eye-specific" layers in a brain structure called the lateral geniculate nuclei, or LGN. Neuroscientists currently think that the pattern of spontaneous activity is essential to "instruct" the formation of separate left and right eye connections to the LGN.

Led by Leo M. Chalupa, professor of ophthalmology and neurobiology, UC Davis researchers Andrew Huberman, Guo-Yong Wang, Lauren Liets, Odell Collins and Barbara Chapman in the Division of Biological Sciences used an antibody coupled to a ribosomal toxin to perturb the activity of selected cells in the retina. The retinal cells still show spontaneous activity, but in a random rather than a normal pattern. Surprisingly, the axons of the optic nerve still grow into the brain normally and form normal layered LGN structures. However, when all activity was completely blocked in the developing retina, the researchers found that the normal separation of left and right eye connections did not occur.

 

""
"" ""
 
"" ""
"" ""
Vertical Seperator Line
"" "" ""
     
"" "" Vertical Seperator Line "" "" "" ""
"" "" Vertical Seperator Line
""

UC DAVIS SCHOOL OF MEDICINE
PUBLIC AFFAIRS
4900 Broadway, Suite1200
Sacramento, California 95820

ucdavismedicine@ucdmc.ucdavis.edu

© 2003 UC Regents. All rights reserved.

"" "" ""