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A Publication of UC Davis School of Medicine

Volume 12 • No 1 • Spring 2015

Body of Knowledge

Noteworthy

A summary of recent findings in clinical, translational and basic science research at UC Davis

A team of UC Davis scientists has found that administering a small molecule – purmorphamine – in animal models after a stroke results in multiple protective effects, including reducing the size of the stroke, decreasing inflammation and increasing markers for nerve regeneration.

Researchers at UC Davis and other institutions have found that diets rich in whole walnuts or walnut oil slowed prostate cancer growth in mice. In addition, both walnuts and walnut oil reduced cholesterol and increased insulin sensitivity. The walnut diet also reduced levels of the hormone IGF-1, which had been previously implicated in both prostate and breast cancer.

A team of UC Davis and University of Arizona researchers discovered that adding the bacteria Bifidobacterium longum subsp. infantis (B. infantis) to formula fed to newborn rats reduced the incidence of necrotizing enterocolitis, an often deadly intestinal infection in babies.

In its first clinical application in pediatric patients, an investigational medication developed and manufactured at UC Davis has been found to effectively treat children with life-threatening and difficult-to-control epileptic seizures without side effects, according to a research report by scientists at UC Davis and Northwestern University.

Immunotherapy that can be effective against tumors in young, thin mice can be lethal to obese ones, a new study by UC Davis researchers has found.

More than 100 scientists, including a team of UC Davis molecular biologists, have sequenced the genomes of 16 Anopheles mosquito species to help define the characteristics that make some of them uniquely capable of transmitting malaria parasites to humans.

Researchers at UC Davis have found that the drug bortezomib effectively treats chronic graft-versus-host disease, a common and debilitating side effect from allogeneic hematopoietic stem cell transplants.