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UC Davis Medicine Logo
The institution's principal publication for alumni, friends and physicians.
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  N E W S  
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"" New avenue for drug development ""
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"" Statins help with heart disease, diabetes ""
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"" New education building opens to students, uniting all four years under one roof ""
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  Rue plant source of new arthritis, diabetes drugs  
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  HIV hides from drugs in gut  
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  OJ drink cuts heart disease risk  
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  Biotechnology pacemakers closer to replacing electronic versions  
     
  NIH funds new center for clinical, translational research  
     
  Vascular surgery broadcast  
     
  NIH grants up  
     
  New associate dean  
     
  New chair for orthopaedic surgery  
     
  New CEO for medical center  
     
  Stereotypes keep men from seeking help  
     
  Better snacks have impact  
     
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NEWS
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New avenue for drug development

UC Davis research shows that compounds known to play an important role in how insects develop from larvae to adults have been shown in a mouse model for congestive heart failure to be effective in preventing and reducing cardiac cell overgrowth and irregular heart rhythms. Findings were published in the Proceedings of the National Academy of Sciences.

The research, led by cardiologist and cell biologist Nipavan Chiamvimonvat and entomology professor Bruce Hammock, identifies epoxide hydrolase inhibitors as novel and powerful chemical compounds that block an immune system protein (NF-B) known to play a role in cardiac cell overgrowth and arrhythmias. The work identifies a new biochemical target for the development of drugs to treat enlargement of the heart and arrhythmias — conditions that have few treatment options and ultimately progress to heart failure and sudden cardiac death.

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UC DAVIS SCHOOL OF MEDICINE
PUBLIC AFFAIRS
4900 Broadway, Suite #1200
Sacramento, CA 95820

ucdavismedicine@ucdmc.ucdavis.edu

© 2007 UC Regents. All Rights Reserved.

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