New Patient ReferralsSenthil Kumar Venugopal, Ph.D.
Clinical/Research InterestsDr. Venugopal's research focuses on liver pathophysiology, gene therapy and oxidative stress. His current research interests include: signal transduction mechanisms of the progression of liver injury in hepatotoxin-induced animal models; the molecular mechanisms involved in controlling the gene expression in liver injury and growth; and developing better therapeutic approaches to improve liver function. |
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Title: |
Assistant Adjunct Professor |
Specialty: |
Gastroenterology and Hepatology, Molecular and Cellular Biology |
Center/Program Affiliation: |
Transplant Center |
Address: |
Research I 4635 2nd Ave., Suite 1105 Sacramento, CA 95817 |
Phone: |
(916) 734-8071 |
Education: |
All India Institute of Medical Sciences New Delhi, India India Ph.D. 2000 |
Education: |
University of Madras Madras India B.S. 1991 |
Professional Memberships: |
American Association for the Advancement of Sciences American Liver Foundation American Society of Biochemistry and Molecular Biology |
Select Recent Publications: |
Venugopal SK, Devaraj S, Jialal I. Macrophage-conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: Potential for paracrine/autocrine effects. Am J Pathol, 166:1265-1271, 2005. Venugopal SK, Devaraj S, Jialal I. Effect of C-reactive protein on vascular cells: Evidence for a proinflammatory, proatherogenic role. Curr Opin Nephrol Hypertens, 14:33-37, 2005. Singh U, Tabibian J, Venugopal SK, Devaraj S, Jialal I. Development of an in-vitro screening assay to test the anti-inflammatory properties of dietary supplements and pharmacological agents. Clin Chem, 2005. (In Press) Devaraj S, Venugopal SK, Singh U, Jialal I. Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-a and -b. Diabetes, 54:85-91, 2005. Devaraj S, Venugopal SK, Jialal I. Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein. Atherosclerosis, 2005. (In Press) Venugopal SK, Devaraj S, Jialal I. Alpha tocopherol inhibits the major scavenger receptor, CD36, expression via inhibition of tyrosine kinase (tyk2) activity. Atherosclerosis, 175:213-220, 2004. Jialal I, Devaraj S, Venugopal SK. C-reactive protein: Risk marker or mediator in atherothrombosis? Hypertension, 44:6-11, 2004. Venugopal SK, Devaraj S, Jialal I. C-reactive protein decreases prostacyclin release from human aortic endothelial cells. Circulation, 108:1676-1678, 2003. Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation, 106:1439-41, 2002. Jialal I, Devaraj S, Venugopal SK. Oxidative stress, inflammation and diabetic vasculopathies: The role of alpha tocopherol therapy. Free Radic Res, 36:1331-1336, 2002. |