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Building on basics

Combinatorial chemistry is focus of $1 million grant

Kit S. Lam, chief of the division of hematology/oncology for the UC Davis Cancer Center, has received a grant of almost $1 million to use combinatorial chemistry to identify novel synthetic compounds that bind to the surfaces of cancer cells.

Using Lam's patented one bead, one compound approach, millions of compounds such as peptides can be created and screened for their ability to bind to the surface of intact tumor cells.

Lam will use a peptide microarray technology to analyze how well these compounds bind to a patient's cancer cells and to determine what biochemical affect they have on cells. Ultimately, these compounds can be used as targeting agents for cancer diagnosis and treatment.

The three-year grant is funded by the NCI.


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Scientists share ideas at one of the symposium's many poster sessions.