truth about cats and dogs
Davis is the ideal setting for this kind of collaborative effort.
It's home to nationally ranked veterinary, agriculture and medical
schools and a place where scientists from across disciplines come
together to answer medical questions.
of the questions London is pursuing involves a proto-oncogene called
c-kit. In its healthy state, c-kit regulates cell differentiation
in mast cells. Damaged, it becomes part of a chain of events that
makes these cells grow out of control.
cells are found in all tissues of the body, especially in those
that serve as ports of entry: the skin, lungs and intestinal tract.
They play an important role in allergies and asthma and in protecting
the body from bacterial infections.
cell cancer is rare in people but extremely common in dogs, usually
manifesting as tumors in the skin. Some breeds are more susceptible
than others, pointing to genetic influences.
few years ago, in collabora- tion with Stephen Galli, a leading
researcher in the field of mast cells, London identified mutations
in c-kit that led to uncontrolled func- tion of the protein. Researchers
have since found similar mutations in at least two forms of human
cancer: stromal tumors of the stomach and acute myelogenous leukemia.
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