laboratory to open at UC Davis Medical Center
In a move that
will boost cancer research at UC Davis, the Jackson Laboratory,
the world's foremost nonprofit institution for mouse-based research,
is establishing a new West Coast collaboration with UC Davis which
will complement the campus's mouse biology program.
The Bar Harbor,
Maine-based laboratory will produce and maintain genetically customized
laboratory mice that will be made available to researchers at UC
Davis and throughout the western United States.
at the facility will include transgenic mice that have genes inserted
to produce physical traits useful in studying the genetic origins
of human diseases.
cancer is a disease of damaged genes, genetically-manipulated mice
provide functional tests of suspected human cancer genes and a platform
for testing gene and drug therapies to combat cancer," says
Hsing-Jien Kung, director of basic science and deputy director of
the UC Davis Cancer Center.
mice let researchers develop animal models for cancer, adds Paul
Gumerlock, an associate professor of hematology/oncology.
get clues about the process of oncogenesis in tissue samples, but
oncogenesis is very different in an organism than in the lab,"
The lab's ability
to "knock-out mice" - animals altered so that genes suspected
of playing a role in certain diseases are mis- sing - will be especially
helpful to scientists like Gumerlock, who is investigating the relationship
of the p27 tumor suppressor gene and resistance to chemotherapy.
Laboratory will work jointly with the Center for Comparative Medicine,
the administrative home to UC Davis' existing Mouse Biology Program.
The new alliance
was devel- oped in response to efforts by the National Institutes
of Health to increase funding and build an infrastructure for mouse-based
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