SpecialtiesDavid G. Greenhalgh, M.D., F.A.C.S.
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| Title: | Professor & Chief, Burn Surgery, UC Davis Medical Center, Department of Surgery Chief, Burns, Shriners Hospitals for Children Northern California Associate Director of Research, Institute for Pediatric Regenerative Medicine |
Office Address: |
UC Davis Department of Surgery - Cypress Building 2221 Stockton Blvd., Sacramento, CA 95817 |
Office phone: |
(916) 734-2680 |
Email address: |
david.greenhalgh@ucdmc.ucdavis.edu |
Born in Syracuse, NY, he attended Hamilton College (Clinton, NY; BA – Chemistry, 1977) and State University of New York, Upstate Medical Center (Syracuse, NY; MD – 1981). He completed a residency in general surgery at the University of Vermont (Burlington, VT) in 1986, followed by a fellowship in surgical research in 1987. He completed two years of burn fellowship at the University of Washington. The burn fellowship included one year of research in the laboratory of Russell Ross, Ph.D., and one year of clinical training at Harborview Medical Center under David Heimbach, M.D. In 1989, he became a faculty member at the Shriners Burns Institute and University of Cincinnati (Cincinnati, OH). In 1997, he became and continues to be Chief of Burns at the Shriners Hospital and UC Davis in Sacramento, CA.
Clinical Program: Dr. Greenhalgh oversees the burn program at both Shriners and UC Davis. All patients 18 years and older are treated at UC Davis and children less than 18 receive free care at the Shriners Hospital. The burn units admit well over 500 acute burn patients per year and see thousands of people in the outpatient clinics. The burn team members will treat any sized burn (from sunburns to the massive injuries). In addition, they will treat other major wounds (traumatic wounds, toxic epidermal necrolysis, purpura fulminans, congenital hairy nevi). To refer a major injury in an adult call: (916) 734-3636 (UC Davis Burn Center). To refer a burned child: call (916) 453-2111 (Shriners ICU). For an outpatient visit, call (916) 734-2680 for an adult or (916) 453-2180 for a child.
Research: Dr. Greenhalgh has published more than 140 papers and chapters related to burns, wound healing and the response to injury. Research in burns covers all areas from the gene regulation of the response to injury, to clinical studies, to methods of preventing burns. He has had continuous funding through the National Institutes of Health or the Shriners of North America. Current basic science projects include: the role of burns in activating the toll-like receptors, the interaction between glucocorticoid receptors and toll-like receptor signaling after burns, the early regulation of scar formation, the roll of endogenous retroviruses in response to injury. Clinical studies include: the role of hemostatic agents in burns, the role of glucocorticoids in response to burns, and factors affecting scarring. Prevention projects include: methods to prevent soup burns, torchiere light injuries, campfire burns, factors in the media that influence the tendency to become burned, and training to prevent scald burns.
Key publications:
Greenhalgh DG, Sprugel KH, Murray MJ, Ross R: PDGF and FGF Stimulate Wound Healing In The Genetically Diabetic Mouse. Am J Path 136: 1235-1246, 1990.
Greenhalgh DG, Hummel RP, III, Albertson S, Breeden MP: The Synergistic Actions of Platelet-Derived Growth Factor and the Insulin-like Growth Factors In Vivo. The Enhancement of Tissue Repair in Genetically Diabetic Mice. Wound Rep Reg 1: 69-81, 1993.
Greenhalgh DG, Warden GD: The Importance of Intra-abdominal Pressure Measurements in Burned Children. J Trauma 36: 685-690, 1994.
Brown DL, Kao WW-Y, Greenhalgh DG. Apoptosis down-regulates inflammation under the advancing epithelial wound edge: Delayed patterns in diabetes and improvement with topical growth factors. Surgery 121: 372-380, 1997.
Brown DL, Kane CD, Chernausek SD, Greenhalgh DG. Differential expression and localization of IGF-I and IGF-II in cutaneous wounds of diabetic versus nondiabetic mice. Am J Pathol 151: 715-724, 1997.
Greenhalgh DG, Gamelli RL, Lee M, Delavari M, Lynch JB, Hansbrough JF, Achauer BM, Miller SF, MacPhee M, Bray G. Multicenter trial to evaluate the safety and potential efficacy of pooled human fibrin sealant for the treatment of burn wounds. J Trauma 46: 433-440, 1999.
Crowe MJ, Doetschman TC, Greenhalgh DG. Expression of TGF- isoform mRNAs during wound healing in immunodeficient TGF-1 knockout mice. J Invest Dermatol 115: 3-11, 2000.
Bridges PE, Palmieri T, Greenhalgh DG. Torchiere-style halogen floor lamps: A need for fire safety awareness. J Burn Care Rehabil 21: 447-449, 2000.
Hobson KG, Cho K, Adamson LK, Greenhalgh DG. Burn-induced thymic apoptosis corresponds with altered TGF-1 and Smad 2/3. J Surg Res 105: 4-9, 2002.
Greenhalgh DG, Palmieri TL. The media glorifying burns: A hindrance to burn prevention. J Burn Care Rehabil 24: 159-162, 2003.
Pham TN, Cho LK, Adamson LK, Hakimbashi M, Yang L, Tredget EE, Greenhalgh DG. Burn injury induces an inhibitory signal in the lung Smad pathway. Cytokine 27: 66-77, 2004.
Cho K, Adamson LK, Jeong J, Crivello SD, VanHook TG, Palmieri T, Greenhalgh DG. CD14-dependent alterations in c-Jun expression in the liver after burn injury. J Surg Res 122: 36-42, 2004.
Cho K, Pham TN, Chamberlain T, Boonyaratanakornkit J, Greenhalgh DG. CD14-mediated alterations in transcription and splicing of endogenous retroviruses after injury. Arch Virol 149: 2215-2233, 2004.
Phan HH, Cho K, Sainz-Lyon KS, Shin S, Greenhalgh DG. CD14-dependent modulation of NF-B alternative splicing in the lung after burn injury. Gene 371: 121-129, 2006.
Greenhalgh DG, Bridges P, Coombs E, Chapyak D, Boyle W, O’Mara MS, Palmieri TL. Instant cup of soup: Design flaws increase risk of burns. J Burn Care Res 27: 476-481, 2006.
