SpecialtiesJane Tang, M.D.
Postdoctoral Scholar
Division of Research
Research interests
The microcirculation manages selective nutrition and fluid exchange between blood and tissue. My research interests focus on microvascular permeability function and its effect factors. Microvessels are sensitive to many internal and external factors (such as mechanic stress, hyperthermia, hypoxia, hypoglycemia, inflammatory factors, sympathetic nerve and endocrine signals, etc). Dysfunction in microvessels results in acute or chronic symptom which may be related with burn, hypersensitivity, stroke, myocardial infarction, diabetes and tumor, etc. VEGF is well known as a major angiogenesis factor and vascular permeability factor (VPF). My current projects are to elucidate: 1) the mechanisms by which VEGF acts on the endothelial cell cytoskeleton causing endothelial cell-cell junction opening and microvascular permeability increase. 2) burn-induced systemic microvascular dysfunction.