Jerome W. Breslin, Ph.D.
Postdoctoral Scholar-Fellow
Division of Research
Department of Surgery
UC Davis Medical Center

1. Microcirculatory physiology
   
   a. Regulation of microvascular permeability under normal and disease conditions.
   b. Signal transduction pathways involved in enhanced microvascular permeability.
   c. Physiology of initial and collecting microlymphatics.
   
   
2. Cell and molecular biology
   
   a. Signal transduction pathways in response to growth factors and inflammatory mediators.
   b. Roles of the cytoskeleton, focal adhesion, and intercellular junctions in endothelial barrier maintenance.
   c. Gene regulation in chronic venous insufficiency, diabetes, and heart disease.
   d. Neutrophil-endothelium interactions.

Breslin JW, Yuan SY, Involvement of RhoA and Rho Kinase in Neutrophil-Stimulated Endothelial Hyperpermeability. Am J Physiol Heart Circ Physiol, 286: H1057-H1062, 2004.

Tinsley JH, Breslin JW, Teasdale NR, Yuan SY, PKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol, 289: L217-L223, 2005.

Breslin JW, Sun H, Xu W, Rodarte C, Moy AB, Wu MH, Yuan SY, Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage. Am J Physiol Heart Circ Physiol, 290: H741-H750, 2006.