Quantcast

UC Davis Health System

Frank R. Sharp, M.D.

Frank R. Sharp

Clinical/Research Interests

Frank Sharp's research focuses on molecular neurobiology, genomics, neural cell injury and cell death and the blood genomics of neurological disease. Prior to his appointment at UC Davis, Sharp had a distinguished clinical and research career at UC San Diego, UC San Francisco and the University of Cincinnati, making groundbreaking contributions to new fields of study and new insights into brain function and disease. Among these contributions were: first laboratory to show proof of principle for using blood genomics to detect pathological events in the animal and human brain, paved the way for performing PET and fMRI studies in humans, and first to demonstrate that a transcription factor can be used to map active neurons. Sharp is currently on the editorial boards of several journals, has been a standing member of the AHA Brain grant review committee, and is a permanent member of the NINDS NSDA review Committee.

Title:

 Professor of Neurology

Specialty:

 Neurology

Center/Program Affiliation:

 UC Davis MIND Institute

Education:

 UC San Diego
La Jolla, California
M.D. 1972

UC Davis
Davis, California
B.S. 1968

Internships:

 Duke University Hospitals
Durham, North Carolina
1973

Residency:

 University of California, San Francisco
San Francisco, California
1979
Neurology

Fellowships:

 National Insititue of Mental Health
Bethesda, Maryland
1976

Board Certifications:

 American Board of Neurology, 1981

Professional Memberships:

 Society for Cerebral Blood Flow and Metabolism
Society for Neurochemistry
Society for Neuroscience

Select Recent Publications:

Tang Y, Gilbert D, Glauser TA, Hershey A, Sharp FR (2005) Blood Gene Expression Profiling of Neurological Diseases - A Pilot Micoarray study Archives of Neurology . 62(2):210-215.

Zhang D, Zhang L, Tang Y, Zhang Q, Lou D, Sharp FR, Zhang J, Xu M. (2005 ) Repeated Cocaine Administration Induces Gene Expression Changes through the Dopamine D1 Receptors.Neuropsychopharmacology 2005 Mar 16.

Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ (2004) Hemin induces heme oxygenase-1 in spinal cord Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. Journal of Neurotrauma. 21(8):1017-1030.

Kim YS, Honkaniemi J, Sharp FR, Tauber MG (2004) Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental Group B streptococcal meningitis. Molecular Brain Research Sep 10; 128(1): 95-102.

Glass TF, Reeves B, Sharp FR (2004) The impact of excitotoxic blockade on the evolution of injury following combined mechanical and hypoxic insults in primary rat neuronal culture.Neurobiology of Disease. Dec;17(3):378-84.

Carter K, Dickerson J, Schoepp DD, Reilly M, Herring N, Williams J, Sallee FR, Sharp JW, Sharp FR (2004) The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis. Neuropharmacology. Dec;47(8):1135-45.

Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, Sharp FR, Rakic P (2004) Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. Journal of Neurosscience Nov ;24(47):10763-10772.

Weinstein PR, Hong S, Sharp FR. (2004) Molecular identification of the ischemic penumbra.Stroke. Nov;35(11 Suppl 1):2666-70.

Sharp FR and Bernaudin M (2004) HIF1 and oxygen sensing in the brain. Nature Review Neuroscience 5(6):437-448.

Tang Y, Lu A, Ran R, Aronow BJ, Schorry EK, Hopkin RJ, Gilbert DL, Glauser TA, Hershey AD, Richtand NW, Privitera M, Dalvi A, Sahay A, Szaflarski JP, Ficker DM, Ratner N, Sharp FR (2004). Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Molecular Brain Research 132(2):155-167.