Fu-Tong Liu specializes in general dermatology with a particular interest in inflammatory skin disorders, including atopic dermatitis, psoriasis, and autoimmune skin diseases, as well as mast cell diseases, such as urticaria and mastocytosis.
As an allergy and immunology researcher, he is a pioneer and leading investigator in the study of a family of proteins called galectins.
His research is focused on their functions in inflammation and immunity, as well as cancer progression and adiposity.
M.D., University of Miami School of Medicine, Miami FL 1987
Ph.D., Organic Chemistry, University of Chicago, Chicago IL 1975
B.S., National Taiwan University, Taipei, Taiwan, 1970
UC San Diego, San Diego CA 1990-1993
American Board of Dermatology, 1993
American Academy of Dermatology
American Association for the Advancement of Science
American Association of Immunologists
American Chemical Society
American Society for Clinical Investigation
American Society for Investigative Pathology
Association of American Physicians
Society of Investigative Dermatology
Honors and Awards
First KIA Laureate, the 28th Khwarizmi International Award, 2015
Fellow, American Association for the Advancement of Science, 2013
Academician, Academia Sinica, Taiwan, 2012
Lu Yau-Chin Memorial Lectureship, Taiwanese Dermatology Society, 2006
Joan Oettinger Memorial Award (Cancer and Pulmonary Research), UC Davis, 2005
Select Recent Publications
Chen, H.-L., Chiang, P.-C., Lo, C.H., Lo, Y.H., Daniel K. Hsu, D.K., Chen, H.Y., Liu, F.-T. Galectin-7 regulates keratinocyte proliferation and differentiation through JNK-miR-203-p63 signaling. J Invest Dermatol, 2016;136:182-91.
Wang, S.-F., Tsao, C.-H., Lin, Y.-T., Hsu, D.K., Chiang, M.-L., Lo, C.-H., Chien, F.-C., Chen, P., Chen, Y.-M., Chen, H.-Y., Liu, F.-T. Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6. Glycobiol, 2014;24:1022-35.
Fermin-Lee, A, Chen, H.-Y., Wan, L., Wu, S.-Y, Yu, J.-S., Huang, A.C., Miaw, S.-C.,Hsu, D.K., Wu-Hsieh, B.A., and Liu, F.-T. Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines. Am J Pathol, 2013;183:1209-22.
Choy, D.F., Hsu, D.K., Seshasayee, D., Fung, M.A., Modrusan, Z., Martin, F. Liu, F.T*., and Arron, J.R*. Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation. J Allergy Clin Immunol, 2012;130:1335-1343 (*co-corresponding author).
Liu, W., Hsu, D.K., Chen, H.-Y., Yang, R.-Y., Carraway KL 3rd, Isseroff RR, Liu, F.-T. Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration. J Invest Dermatol. 2012;132:2828-37.
Yang, R.-Y., Yu, L., Graham, J., Hsu, D.K., Lloyd, K.C., Havel, P.J., and Liu, F.-T. Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci USA 2011;108:18696-701.
Saegusa, J., Hsu, D.K., Chen, H.-Y., Yu, L., Fermin, A., Fung, M.A., and Liu, F.-T. Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis. Am J Pathol, 2009;174:922-931.
Chen, H-Y., Fermin, A., Vardhana, S., Weng, I-C., Lo, K.F.R., Chang,E-Y., Maverakis, E., Yang, R.Y., Hsu, D.K., Dustin, M., and Liu, F.-T. Galectin-3 negatively regulates TCR-mediated CD4 T cell activation at the immunological synapse, Proc Natl Acad Sci USA, 2009;106:14496-14501.
Hsu, D.K., Chen, H.-Y., Yu, L., Chernyavsky, A.I., Grando, S.A., and Liu, F.-T. Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol, 2009;129:573-83.
Liu, F-T. and Rabinovich, G.A. Galectins as novel modulators of tumor progression. Nature Rev Cancer, 2005;5: 29-41.