Dr. Alexander Borowsky's clinical interests include: Breast Diagnostics, Ductal Carcinoma in situ (DCIS), Molecular Cancer Diagnosis, Breast Health/Risk Assessment, Genomics and Prostate Cancer.
Dr. Borowsky's research interests include: Pathology of mouse models of cancer, modeling pre-cancer to investigate mechanisms of neplastic progression.
M.D., Vanderbilt University School of Medicine, Nashville TN 1994
B.A., Pomona College, Claremont CA 1989
Pathology, Vanderbilt Medical Center, Nashville TN 1994-1996
Pathology/Cancer, Harvard Medical School, Brigham and Women's Hospital, Boston MA 1998-2001
Pathology/Breast Pathology, Vanderbilt Medical Center, Nashville TN 1996-1997
American Board of Pathology, Anatomic Pathology,
American Association for the Advancement of Science
American Association of Cancer Research
College of American Pathologists
United States and Canadian Academy of Pathology
Honors and Awards
Deans Team Award for Excellence in Research, 2015
State of California Breast Cancer Research Award, 2005
UC Davis Health Science Research Award, 2002
UC Cancer Research Coordinating Committee Award, 2002
Stowell-Orbison Prize, awarded to the outstanding paper presented by a pathologist-in-training, US and Canadian Academy of Pathology Mtg, 1997
John Shapiro Award for Excellence in Pathology, Vanderbilt School of Medicine, 1994
Select Recent Publications
Kuil J, Buckle T, Oldenburg J, Yuan H, Borowsky AD, Josephson L, van Leeuwen FW. Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression. Mol Pharm. 2011 Dec 5;8(6):2444-53. Epub 2011 Nov 15.
Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, Dunphy KA, Seo JH, Haslam S, Medina D, Barcellos-Hoff MH. Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type. Cancer Cell. 2011 May 17;19(5):640-51.
Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1753-61. Epub 2011 Feb 18.
de Leoz ML, Young LJ, An HJ, Kronewitter SR, Kim J, Miyamoto S, Borowsky AD, Chew HK, Lebrilla CB. High-mannose glycans are elevated during breast cancer progression. Mol Cell Proteomics. 2011 Jan;10(1):M110.002717. Epub 2010 Nov 19.
Rygh CB, Qin S, Seo JW, Mahakian LM, Zhang H, Adamson R, Chen JQ, Borowsky AD, Cardiff RD, Reed RK, Curry FR, Ferrara KW. Longitudinal investigation of permeability and distribution of macromolecules in mouse malignant transformation using PET. Clin Cancer Res. 2011 Feb 1;17(3):550-9. Epub 2010 Nov 24.
Flowers M, Schroeder JA, Borowsky AD, Besselsen DG, Thomson CA, Pandey R, Thompson PA. Pilot study on the effects of dietary conjugated linoleic acid on tumorigenesis and gene expression in PyMT transgenic mice. Carcinogenesis. 2010 Sep;31(9):1642-9. Epub 2010 Jul 11.
Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW. ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res. 2010 Nov 15;70(22):9402-12. Epub 2010 Sep 23.
Kheirolomoom A, Mahakian LM, Lai CY, Lindfors HA, Seo JW, Paoli EE, Watson KD, Haynam EM, Ingham ES, Xing L, Cheng RH, Borowsky AD, Cardiff RD, Ferrara KW. Copper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity. Mol Pharm. 2010 Dec 6;7(6):1948-58.
Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, Mercola D, Carpenter PM, Bowtell D, Ronai ZA. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell. 2010 Jul 13;18(1):23-38.
Adamson TW, Kendall LV, Goss S, Grayson K, Touma C, Palme R, Chen JQ, Borowsky AD. Assessment of carprofen and buprenorphine on recovery of mice after surgical removal of the mammary fat pad. J Am Assoc Lab Anim Sci. 2010 Sep;49(5):610-6.