Amanda Robinson Kirane, M.D.
Skin Cancer and Melanoma
Minimally Invasive Surgery
- Assistant Professor
UC Davis Comprehensive Cancer Center
2279 45th Street
Sacramento, CA 95817
Additional Phone Numbers
Physician Referrals: 800-4-UCDAVIS (800-482-3284)
Philosophy of Care
Dr. Kirane aims to provide compassionate care as a partnership with her patients and their families with respect to each patient's individual needs. In complex cases, a multi-disciplinary team of specialists within the cancer center will collaboratively coordinate in effort to help guide our patients in decision making to ensure the highest quality care.
Dr. Kirane is a fellowship trained Complex General Surgical Oncologist with specialty training in Melanoma, other skin cancers, and soft tissue diseases as well as minimally invasive approaches to oncologic surgery in soft tissue, gastric, and hepatobiliary cancers.
Her clinical interests include regional therapies for locally advanced soft tissue cancers, including isolated limb infusion, as well as evolving technologies and therapies in advanced melanoma cases. She passionately believes in personalized medicine using evidence-based best practice to tailor treatment to each individual patient.
Dr. Kirane's academic interests include basic and translational science research in melanoma and sarcoma with specific interest in mechanisms of evasive resistance, tumor microenvironment signaling and immune response. Being able to move from bench to bedside and return allows for the rapid adaptation of surgical science to improved patient care.
Her previous bench work has resulted in multiple ongoing trials of novel therapeutic strategies in pancreatic cancer. She is also invested in surgical education and clinical trials for novel targets in resistant melanoma.
M.D., University of Texas Southwestern Medical School, Dallas TX 2006
B.A., University of Texas, Austin TX 2002
General Surgery, Southwestern Medical Center, Dallas TX 2007-2009, 2012-2014
Physician-Scientist in Oncology, Hamon Center for Therapeutic Oncology Research, Dallas TX 2009-2012
Complex General Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York NY 2014-2016
da Vinci Surgery in General Surgical Oncology,
American Association of Cancer Research
American College of Surgery
Association of Academic Surgeons
Association of Women Surgeons
Connective Tissue Oncology Society
Society of Surgical Oncology
The Society for Melanoma Research
Honors and Awards
David and Monica Gorin Award of Courage Fellow, Memorial Sloan Kettering Cancer Center, 2015
Society of Surgical Oncology, Best Basic/Translational Science Award, 2015
Select Recent Publications
Kirane A, Crago AM. The importance of surgical margins in retroperitoneal sarcoma. J Surg Oncol. 2016 Mar;113(3):270-6.
Kiranea, A and Brennan, MF. The Management of Soft TIssue Sarcoma, Cameron Current Surgical Therapy 12th edition. 2016.
Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, Toombs JE, Wang M, Dineen SP, Micklem D, Dellinger MT, Lorens JB, Brekken RA. Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis. Cancer Res. 2015 Sep 15;75(18):3699-705.
Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, Schwarz RE, Burrows FJ, Brekken RA. Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer. Clin Cancer Res. 2012 Sep 15;18(18):5031-42.
Kirane A, Toombs JE, Larsen JE, Ostapoff KT, Meshaw KR, Zaknoen S, Brekken RA, Burrows FJ. Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. Carcinogenesis. 2012 Sep;33(9):1639-46.
Awasthi N, Kirane A, Schwarz MA, Toombs JE, Brekken RA, Schwarz RE. Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer. BMC Cancer. 2011 Jan 12;11:15.
Bao JJ, Mansour JC, Timmerman RD, Kirane A, Ewing GE, Schwarz RE. Intraduodenal sarcoma recurrence of retroperitoneal origin: an unusual cause for a duodenal obstruction. World J Surg Oncol. 2012 Apr 20;10:59.