Jacqueline Crawley, Ph.D.

Jacqueline N. Crawley, Ph.D.

Specialties

Behavioral Neuroscience

Title

  • Professor, Department of Psychiatry and Behavioral Sciences
  • Robert E. Chason Endowed Chair in Translational Research

Research II

4625 2nd Ave., Suite 1001
Sacramento, CA 95817
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Clinical Interests

Jacqueline N. Crawley, Ph.D., is an internationally recognized leader in behavioral neuroscience, mouse behavioral genetics, and translational neuropharmacology. Dr. Crawley joined the University of California Davis in July 2012 as the Robert E. Chason Endowed Chair in Translational Research at the MIND Institute and Professor in Residence in the Department of Psychiatry and Behavioral Sciences at the UC Davis School of Medicine. Her research program focuses on rodent models of neuropsychiatric disorders. Current emphasis is on understanding the genetic causes of autism spectrum disorders, and discovering effective medical therapeutics for the core diagnostic symptoms of autism. Mouse models are used as preclinical research tools to test hypotheses about the etiology of autism and to evaluate the therapeutic benefit of proposed treatment interventions.

Dr. Crawley received her B.A. in biology from the University of Pennsylvania, Ph.D. in zoology from the University of Maryland, and conducted postdoctoral research in neuropsychopharmacology at Yale University School of Medicine. As an intramural investigator in the National Institute of Mental Health Intramural Research Program in Bethesda, Maryland from 1983 to 2012, she served as Chief of the Laboratory of Behavioral Neuroscience. Her laboratory has published over 260 papers and 100 reviews. She serves on 16 journal editorial boards and numerous scientific advisory committees. Honors include the Distinguished Scientist Award from the International Behavioral and Neural Genetics Society, Myers Lifetime Achievement Award from the International Behavioral Neuroscience Society, Society for Neuroscience Service Award, Fleur Strand Lecture Award from the Summer Neuropeptide Conference, Gladstone Institute of Neurological Disease Distinguished Scholar Award, MIND Institute Distinguished Lecturer, Mathilde Solowey Lecture Award in Neuroscience, NIMH Director’s Award, and Howard Hughes Medical Research Institute Preceptor Award. She serves on numerous review boards and councils, and is a Fellow of the American Association for the Advancement of Science.

The Crawley lab developed a multi-tiered strategy for behavioral phenotyping of mutant mice which has been widely adapted by the international biomedical research community. Her sole authored book, What's Wrong With My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, has become the primer for the field. Beginning in 2000, Dr. Crawley’s team pioneered mouse behavioral tasks with conceptual relevance to the diagnostic symptoms of autism, which are employed by many research groups investigating lines of mice with mutations associated with autism spectrum disorders. Her expertise in mouse behavioral phenotyping offers a unique collaborative resource to the UC Davis research community.

Center/Program Affiliation

UC Davis MIND Institute

Education

Ph.D., University of Maryland, College Park MD 1976

B.A., University of Pennsylvania, Philadelphia PA 1971

Professional Memberships

American Association for the Advancement of Science (Fellow, 2011)

American College of Neuropsychopharmacology

Association for Psychological Science (Fellow)

Behavior Genetics Association

Council Member, International Neuropeptide Society

European Neuropeptide Club

International Behavioral and Neural Genetics Society

International Behavioral Neuroscience Society (Fellow)

International Neuropeptide Society (Founding Member)

International Society for Autism Research

Member, Awards Committee, International Behavioural and Neural Genetics Society

Member, External Advisory Committee, NeuroTherapeutics Research Institute, University of California Davis

Member, Scientific Council, NARSAD Brain and Behavior Research Foundation

Society for Behavioral Neuroendocrinology

Society for Neuroscience

Honors and Awards

Distinguished Scientist Award, International Behavioural and Neural Genetics Society, 2011

Special Achievement Award, National Institute of Mental Health, 2011

National Institute of Mental Health Director?s Merit Award, 2010

President, International Behavioral and Neural Genetics Society, 2010

Autism Awareness Day Keynote Award, University of Albany, 2009

Howard Hughes Medical Research Institute Preceptor Award, Student Internship Program, 2007

Fleur Strand Lecture Award, Summer Neuropeptide Conference, 2005

Marjorie A. Myers Lifetime Achievement Award, International Behavioral Neuroscience Society, 2005

Select Recent Publications

Kazdoba TM, Leach PT, Yang M, Silverman JL, Solomon M, Crawley JN. Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics. Curr Top Behav Neurosci. 2016;28:1-52.

Leach PT, Hayes J, Pride M, Silverman JL, Crawley JN. Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task. eNeuro. 2016 Mar 15;3(1). eCollection 2016 Jan-Feb.

Crawley JN, Heyer WD, LaSalle JM. Autism and Cancer Share Risk Genes, Pathways, and Drug Targets. Trends Genet. 2016 Mar;32(3):139-46.

Yang M, Lewis FC, Sarvi MS, Foley GM, Crawley JN. 16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks. Learn Mem. 2015 Nov 16;22(12):622-32.

Kazdoba TM, Leach PT, Crawley JN. Behavioral phenotypes of genetic mouse models of autism. Genes Brain Behav. 2016 Jan;15(1):7-26.

Silverman JL, Pride MC, Hayes JE, Puhger KR, Butler-Struben HM, Baker S, Crawley JN. GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism. Neuropsychopharmacology. 2015 Aug;40(9):2228-39.

Silverman JL, Smith DG, Sukoff Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN: Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Science Translational Medicine. 2012; 4:131ra51.

Yang M, Bozdagi O, Scattoni ML, Wohr M, Roullet FI, Katz AM, Abrams DN, Kalikhman D, Simon H, Zhang J, Harris M, Woldeyohannes L, Zhang JY, Harris MJ, Saxena R, Silverman JL, Buxbaum JD, Crawley JN: Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice. The Journal of Neuroscience. 2012; 32: 6525-6541.

Scattoni ML, Ricceri L, Crawley JN: Unusual repertoire of vocalizations in adult BTBR Ttf/J mice during three types of social encounters. Genes, Brain Behavior.  2011;10: 44-56.

McFarlane HG, Kusek GK, Yang M, Phoenix JL, Bolivar VJ, Crawley JN: Autism-like behavioral phenotypes in BTBR Ttf/J mice. Genes, Brain and Behavior. 2008;7: 152-163.

Chadman KK, Gong S, Scattoni ML, Boltuck SE, Gandhy S, Heintz N, Crawley JN: Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice. Autism Research.  2008; 1: 147-158.