Barbara L. Shacklett, Ph.D.
Cellular and Mucosal Immunology
Human Immunodeficiency Virus (HIV)
- Professor of Medical Microbiology and Immunology
- Scientific Director, Flow Cytometry Shared Resource, UC Davis Comprehensive Cancer Center
Our main topic of research is chronic HIV infection, with an emphasis on the body's immune response to HIV in the gastrointestinal and reproductive tracts as well as the central nervous system.
We are also very interested in HIV prevention strategies, including vaccines and microbicides. Work in the laboratory is funded by grants from the National Institutes of Health (NIH).
Our major areas of study can be summarized as:
1) Cellular Immunology: T-cell biology, innate-like T-cell subsets
2) Mucosal Immunology: Adaptive immunity in the gastrointestinal and reproductive tracts
3) Infectious Diseases: HIV and other sexually transmitted diseases. Emerging viruses.
4) Human Immunodeficiency Virus (HIV): Pathogenesis, vaccine development, prevention strategies.
Medical Microbiology and Immunology
Ph.D., Microbiology, UC Davis, Davis CA 1994
B.S., Microbiology, Rutgers University, New Brunswick NJ 1985
Postdoctoral Fellowship, Aaron Diamond AIDS Research Center, New York NY 1997-1999
Postdoctoral Fellowship, Institut Cochin, Paris, France 1994-1997
American Association of Immunologists (AAI)
American Society for Microbiology (ASM)
International AIDS Society (IAS)
Society for Mucosal Immunology (SMI)
Select Recent Publications
Shanmugasundaram, U., Critchfield, J.W., Pannell, J., Perry, J., Giudice, L.C., Smith-McCune, K., Greenblatt, R.M., and Shacklett, B.L. Phenotype and functionality of CD4+ and CD8+ T-cells in the upper reproductive tract of healthy premenopausal women. Am J of Reproductive Immunology. 2014;71(2):95-108.
Hayes, T.L., Critchfield, J.W., Knight, T.H., McLaughlin, B.E., Yotter, T., McConnell, D.H., Garcia, J.C., Pollard, R.B., Asmuth, D.M., and Shacklett, B.L. Impact of HAART initiation on CD4+ T-cell repopulation in small and large intestinal mucosa. AIDS. 2013;27(6):867-877.
Shaw, J.M., Hunt, P.W., Critchfield, J.W., McConnell, D.H., Garcia, J.C., Pollard, R.B., Somsouk, M., Deeks, S.G., and Shacklett, B.L. Increased frequency of regulatory T-cells accompanies increased T-cell immune activation in rectal mucosae of HIV+ non-controllers. J of Virology. 2011;85:11422-11434.
Ferre, A.L., Hunt, P.W., Critchfield, J.W., McConnell, D.H., Garcia, J.C., Pollard, R.B., Deeks, S.G., and Shacklett, B.L. HIV controllers with HLA-DRB1*13 and DQB1*06 have strong, polyfunctional mucosal CD4+ T-cell responses. J of Virology. 2010;84:11020-9.
Ferre, A.L., Lemongello, D., Morris, M.M., Schreiber, M.A., Garcia, J.C., Asmuth, D.M., Pollard, R.B., and Shacklett, B.L. Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers. J of Virology. 2010;84:10354-65.
Ferre, A.L., Hunt, P., Critchfield, J.W., Young, D.H., Morris, M.M., Garcia, J.C., Pollard, R.B., Yee, H.F., Martin, J.N., Deeks, S.G., and Shacklett, B.L. Mucosal Immune Responses to HIV-1 in Elite Controllers: A Potential Correlate of Immune Control. Blood. 2009;113:3978-89.
Shacklett, B. Mucosal Immunity to HIV, pp 1-13, in: Encyclopedia of AIDS, 1st Ed., T. Hope, D.D. Richman and M. Stevenson, Eds., New York, Springer Press. 2014; ISBN 978-1-4614-9610-6. DOI: 10.1007/978-1-4614-9610-6_197-1.